Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

New strategy using organoids to study childhood brain tumors

A new study reports the creation of in vitro models of brain tumors in children using organoids derived from stem cells, which will help to screen new drugs for efficacy and thus improve the rate of drug development. The study, titled 'Modeling medulloblastoma in vivo and with human cerebellar organoids,' is published in the journal Nature Communications.

29 Jan 2020

Researchers develop new strategy to study childhood brain tumors

Researchers are at work to find effective treatments to help young patients with brain tumors. Hundreds of brain organoids have been developed in the laboratories of the University of Trento to understand the genetic mechanisms responsible for these hard to treat diseases.

29 Jan 2020

Snake stem cells create real venom to use as medicine

Poisonous snakes kill more than 90,000 people each year across the globe, with about 1.2 million to 5.5 million snake bites occur annually. Despite the venomous bite, scientists have limited knowledge of the snake’s venom, complicating efforts to develop treatments. A new study has found that snake venom gland cells can be cultured in the lab as adult-stem-cell-based organoids, producing real venom, which can be used to develop treatments.

26 Jan 2020

Researchers grow venom-producing snake organoids in the lab

Researchers from the group of Hans Clevers at the Hubrecht Institute, in an international collaboration, have developed a method to grow snake venom gland cells as organoids.

23 Jan 2020

A two-drug combo that halts growth of cancer cells discovered

UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations.

23 Jan 2020

Patient-specific tumor organoids may one day be used to personalize cancer treatment

A patient-specific tumor organoid platform developed by Wake Forest Institute for Regenerative Medicine researchers and their cancer center colleagues could someday take the guessing game out of immunotherapy treatments.

21 Jan 2020

Discovery of mechanism by which Zika virus enters brain cells

Two independent studies published by Cell Press on January 16, 2020, report that the mechanism by which Zika virus enters brain cells has been identified and even more, exploited to prevent Zika infection and to kill cancer cells instead.

16 Jan 2020

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Emulate, Inc. announced today a published study in collaboration with Johns Hopkins University School of Medicine, that demonstrated superior functionality of the Duodenum Intestine-Chip populated with organoids, compared to organoids alone.

14 Jan 2020

Boston researchers develop novel approach to generate intestinal organoids in vitro

Boston researchers have developed a new way to generate groups of intestinal cells that can be used, among others, to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system.

11 Jan 2020

Research adds definitive evidence about how the body's earliest immune cells are formed

One day the advance could lead to a patient's own skin cells being used to produce new cells for cancer immunotherapy or to test autoimmune disease interventions.

8 Jan 2020

Cornell study details role of stem cell in deadly gastric cancer

A Cornell study provides important new insights into a common and deadly type of gastric cancer.

7 Jan 2020

Researchers discover glioblastoma origins using brain organoids

Glioblastomas are the most aggressive form of brain cancer -; they grow and spread rapidly through the brain and are virtually impossible to eradicate, typically leading to death within one or two years of diagnosis.

6 Jan 2020

Lab-grown brain organoids may hold the answers to personalized treatments for glioblastomas

Lab-grown brain organoids developed from a patient's own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it.

26 Dec 2019

Brazilian researchers create hepatic organoids by 3D bioprinting

Using human blood cells, Brazilian researchers have succeeded in obtaining hepatic organoids ("mini-livers") that perform all of the liver's typical functions, such as producing vital proteins, storing vitamins, and secreting bile, among many others.

17 Dec 2019

Immune cells repair damaged gut in children with IBD

According to a new study published in the journal Gastroenterology, immune cells of a certain kind which regulate inflammatory processes and even help restore normal gut function after inflammation could be of great use to treat children with inflammatory bowel disease (IBD).

11 Dec 2019

Gut disease and gene analysis networks

Gut diseases are difficult to diagnose in many cases, and their underlying dysfunction is hard to understand in many cases. Now, a new study published in the journal Molecular Omics promises to uncover a better insight into how these conditions occur and their mechanisms, by providing a deeper look at how genes interact in complex ways in health and fail to do so in disease.

11 Dec 2019

Bruker launches Luxendo TruLive3D Imager light-sheet imaging system

At the 2019 joint meeting of the American Society for Cell Biology and European Molecular Biology Organization, Bruker today announced the launch of the Luxendo TruLive3D Imager light-sheet imaging system.

From Bruker Nano Surfaces and Metrology 11 Dec 2019

A network approach to explore the causes of IBD

Diseases of the gut are often notoriously difficult to diagnose, nevermind understand, which is where a network-based approach comes in.

10 Dec 2019

New technique holds promise in cancer research and science studies

A new technique reported this week in Science overcomes several limitations of typical high-throughput chemical screens conducted on cell samples. Such screens are commonly used to try to discover new cancer drugs, and in many other biomedical applications.

8 Dec 2019

FDA-approved drug repairs gut leakiness associated with ulcerative colitis

A research team led by biomedical scientists at the University of California, Riverside, has found that a drug approved by the FDA to treat rheumatoid arthritis and ulcerative colitis can repair permeability defects in the gut's epithelium.

4 Dec 2019