Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Brain organoids provide new insights into HSV-1 encephalitis

The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists with the Rajewsky and Landthaler labs and the Organoid Platform at the Max Delbrück Center in Nature Microbiology.

22 Jun 2023

Researchers use an unprecedented stem cell zoo to study developmental time

In humans, pregnancy lasts around nine months. In mice, only 20 days, and in rhinoceroses, as long as 17 months. Although many mammalian species go through the same stages during embryo development, the speed of development differs substantially across animals.

20 Jun 2023

Unveiling ancient minds: fossil endocasts unlock secrets of past brains

Study summarized the knowledge of brain anatomy from fossil records and brain evolution.

15 Jun 2023

Scientists uncover the structure of the first step in amyloid formation for Huntington's disease

Devastating neurodegenerative diseases like Huntington's, Alzheimer's, and Parkinson's are all associated with protein deposits in the brain, known as amyloid.

13 Jun 2023

New cell culture model generates the alveolar macrophage in the lab

Researchers at Texas Biomedical Research Institute have succeeded in generating the lung's most important immune cell, the alveolar macrophage, in the lab.

12 Jun 2023

Mechanistic insights into how the SARS-CoV-2 virus affects the nervous system, alters its function, and causes neuropathology

Study demonstrates that SARS-CoV-2 infection and viral fusogens cause glial and neuronal fusion.

9 Jun 2023

Weak spot discovery could pave way for more effective cancer therapies

Prostate cancer is the most common non-skin cancer in men worldwide. According to international estimates about one in six men will get prostate cancer during their lifetime and worldwide, over 375'000 patients will die from it each year.

8 Jun 2023

New strategy to grow and measure how tumor organoids respond to therapy

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers.

7 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

Targeting stem cells from the human stomach for treating diabetes

Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study from researchers at Weill Cornell Medicine.

25 May 2023

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

In this interview, we spoke to Adrian Krainer, a Professor at Cold Spring Harbor Laboratory, about his latest research into the role of RNA splicing in one of the deadliest forms of pancreatic cancer.

22 May 2023

Patient-derived head and neck cancer organoids could aid the discovery of novel therapies

Researchers from the Organoid group (Hubrecht Institute) and UMC Utrecht have developed a biobank with organoids derived from patients with head and neck cancer (HNC).

12 May 2023

New CRISPR genome-editing technology helps scientists to explore many cancer-linked mutations

Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development.

11 May 2023

High-resolution atlas illustrates the development of human retina

What cell types are found in which human tissue, and where? Which genes are active in the individual cells, and which proteins are found there?

8 May 2023

Organoids derived from cancer cells can reduce the need for trial and error in identifying effective treatments

Researchers created organoids from cancer cells to reduce the need for trial and error in identifying effective cancer treatments in one of many cancer studies scheduled for presentation this week at Digestive Disease Week (DDW) 2023.

8 May 2023

Organoid models provide new scientific insights into a rare childhood liver cancer

Scientists of the Princess Máxima Center for pediatric oncology and Hubrecht Institute in the Netherlands have revealed new scientific insights into the features of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer

3 May 2023

Mechanism to protect the liver from destruction in case of obesity revealed

Scientists from the Immanuel Kant Baltic Federal University found out that blocking of receptor gp130 on the surface of liver cells helps to protect this organ from destruction in case of obesity.

27 Apr 2023

Researchers explore the role of a genetic process in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. It's also one of the deadliest. More than 90% of PDAC patients die within five years of diagnosis.

26 Apr 2023

Study indicates that SARS-CoV-2 has evolved to gain increased replicative fitness and become well-adapted in epithelial cells of human airways

Researchers explored increasing replicative fitness of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants

20 Apr 2023

New approach identifies significant molecular changes linked to pediatric bipolar disorder

It's extremely difficult to study the biological basis of psychiatric disorders, in part because researchers can't easily collect brain cells from living people to study in the laboratory. Now, University of Utah Health scientists have developed a way around that.

12 Apr 2023