Osteoclast News and Research

RSS

Long-term chronic bone loss occurs even after one time malaria infection

Malaria caused by Plasmodium parasites is a life-threatening infectious disease that kills at least half a million people annually while causing over 200 million new infections.

2 Jun 2017

South Asian women could be at greater risk of developing osteoporosis in later life, study finds

Pre-menopausal South Asian women could be more at risk of developing osteoporosis in later life than white Caucasian women, a new study in the Journal Bone reports.

21 Mar 2017

Commonly-prescribed drug for treating weak bone condition linked to increased risk of 'micro-cracks'

A type of drug used to treat weak bones is associated with an increased risk of 'micro-cracks' in bone, according to new research.

1 Mar 2017

Researchers provide insights into effects of microgravity on bone tissue

As is well-known, space flights bring with them a unique set of health hazards. That includes bone and muscle deterioration. Loss of bone density is currently one of the most serious problems for astronauts.

28 Jan 2017

Real-time study of medaka fish aboard ISS sheds light on bone metabolism under microgravity

Tokyo Institute of Technology research: Gravitational biology: Real time imaging and transcriptome analysis of medaka aboard space station

11 Jan 2017

Scientists discover way to visualize function of bone-resorbing cells in living mice

Researchers of Osaka University have discovered a way to visualize sites where bone-resorbing cells (osteoclasts) were in the process of resorbing bone in living mice.

17 Aug 2016

Saint Louis University receives NIH grant to investigate development of new drugs to treat bone diseases

David Griggs, Ph.D., director of biology at Saint Louis University's Center for World Health & Medicine, has received a $1 million R01 grant from the National Institutes of Health to investigate the development of what could be a new class of drugs to treat bone diseases.

30 Sep 2015

New article shows taxonomic classification of rare genetic bone disorders based on metabolic phenotypes

An International Osteoporosis Foundation Working Group on Skeletal Rare Diseases has published a new classification of rare genetic metabolic bone disorders (RGMBDs) according to their metabolic pathogenesis.

18 Jun 2015

Researchers develop new method for preventing destructive activity of osteoclasts

Most existing treatments for pathological bone loss inhibit osteoclasts (bone-destroying cells) to limit bone degradation. However, by doing this, they also prevent bone formation since it is stimulated by the presence of these very same osteoclast cells. Researchers from the CNRS, Inserm and the Université de Montpellier and Université Jean Monnet - Saint-étienne have developed a new approach for preventing the destructive activity of osteoclasts without affecting their viability.

12 Feb 2015

Alizé Pharma obtains exclusive worldwide rights to develop new therapy for bone diseases

Alizé Pharma III SAS, an Alizé Pharma group company specialized in the development of biopharmaceuticals to treat metabolic disorders and rare diseases, today announces that it has acquired exclusive worldwide rights to develop and commercialize a new family of peptides with bone anabolic properties.

4 Dec 2014

Experiments show that 'unsung' cells are crucial to the process of bone loss caused by bone disorder

Experiments in mice with a bone disorder similar to that in women after menopause show that a scientifically overlooked group of cells are likely crucial to the process of bone loss caused by the disorder, according to Johns Hopkins researchers.

6 Oct 2014

New class of anti-arthritic drugs reduce arthritic joint inflammation and periodontitis

Inflammatory diseases can occur simultaneously in distinct sites in the same patient, complicating treatment because a medication effective for one disorder may exacerbate the other.

10 Jul 2014

Researchers discover certain proteins in osteoclasts that may be used to destroy cardiovascular calcification

Cardiovascular calcification (deposits of minerals in heart valves and blood vessels) is a primary contributor to heart disease, the leading cause of death among both men and women in the United States according the Centers for Disease Control and Prevention (CDC).

17 Mar 2014

Finding could lead to new treatments for osteoporosis

Scientists at Washington University School of Medicine in St. Louis have discovered what appears to be a potent stimulator of new bone growth. The finding could lead to new treatments for osteoporosis and other diseases that occur when the body doesn't make enough bone.

31 Jan 2014

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

Bone homeostasis requires precise balance between deposition of new bone by osteoblasts and resorption of old bone by osteoclasts. Bone diseases, including osteoporosis and rheumatoid arthritis, are the result of increased osteoclast activity and formation, which allows bone resorption to outpace deposition.

9 Dec 2013

Findings suggest new approach for treating inflammatory bone diseases and skeletal metastases

The skeleton is constantly being remodelled by the breakdown of old bone by cells called osteoclasts and the formation of new bone by cells called osteoblasts. This coordinated activity is essential for maintaining healthy bone. However, excessive osteoclast activity leads to bone destruction in skeletal diseases such as osteoporosis, rheumatoid arthritis and cancer metastases in bone. A family of signaling enzymes known as phosphatidylinositol 3-kinases control diverse cell functions but, up until now, little was known about the function of specific PI3K isoforms in osteoclasts.

5 Dec 2013

Osteoclast News and Research

Long-term chronic bone loss occurs even after one time malaria infection

South Asian women could be at greater risk of developing osteoporosis in later life, study finds

Commonly-prescribed drug for treating weak bone condition linked to increased risk of 'micro-cracks'

Researchers provide insights into effects of microgravity on bone tissue

Real-time study of medaka fish aboard ISS sheds light on bone metabolism under microgravity

Scientists discover way to visualize function of bone-resorbing cells in living mice

Saint Louis University receives NIH grant to investigate development of new drugs to treat bone diseases

New article shows taxonomic classification of rare genetic bone disorders based on metabolic phenotypes

Researchers develop new method for preventing destructive activity of osteoclasts

Alizé Pharma obtains exclusive worldwide rights to develop new therapy for bone diseases

Experiments show that 'unsung' cells are crucial to the process of bone loss caused by bone disorder

New class of anti-arthritic drugs reduce arthritic joint inflammation and periodontitis

Researchers discover certain proteins in osteoclasts that may be used to destroy cardiovascular calcification

Finding could lead to new treatments for osteoporosis

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

Findings suggest new approach for treating inflammatory bone diseases and skeletal metastases

Study suggests novel approach for treatment of advanced metastatic prostate cancers

Researchers discover link between NOX4 enzyme and osteoporosis

microRNAs may serve as therapeutic targets and predictors of metastasis

Preclinical study of cabozantinib in prostate cancer bone metastasis model presented at AACR meeting

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

Latest News