Pathophysiology News and Research

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Classifying heart failure patients based on redox status may help personalize treatment

For more than six decades, oxidative stress has been linked to heart failure, a progressive weakening of the heart muscle that can lead to death. While antioxidant supplements such as vitamin C, vitamin B and beta-carotene have been widely used in heart failure, they often prove ineffective.

6 Jun 2018

Study highlights complexity of the brain’s molecular response to cocaine use

A study in Biological Psychiatry has identified unique genetic changes in the brain's reward circuitry that are associated with cocaine use, including first-time use, withdrawal, and re-exposure to the drug after prolonged withdrawal.

31 May 2018

New study estimates current prevalence of eating disorders in the United States

Biological Psychiatry has published a new study revising the outdated estimates of the prevalence of eating disorders in the United States.

30 May 2018

Brain abnormality linked to general risk for mental illness

A new study by researchers at Duke University reports an abnormality in visual regions of the brain that is associated with a person's general risk for mental illness.

17 May 2018

Study finds new molecular mechanism for neurodegeneration in frontotemporal dementia

A new study in Biological Psychiatry reports that dementia-related and psychiatric-related proteins cluster together to form aggregates in the brain, leading to abnormal cell function and behavior.

8 May 2018

Greater parent-child communication protects against harmful health behaviors

Children with greater parent communication in early adolescence have less harmful alcohol use and emotional eating in young adulthood, according to a new study in Biological Psychiatry.

3 May 2018

Improving the Diagnosis of Cardiac Sarcoidosis

Cardiac sarcoidosis is an inflammatory disease of the heart that results in various clinical manifestations. Dr Nadera Sweiss discusses her research in the field of sarcoidosis and how diet can influence the diagnosis of the condition.

30 Apr 2018

Flesh eating ulcer cases on the rise in Victoria

Recent reports have shown a rise in cases of flesh eating ulcers in and around Victoria, Australia. Health experts have said that this could become a serious problem if not handled carefully. They have called for funds to deal with this menace. These flesh eating ulcers, according to sources have infected hundreds of individuals in regional Victoria.

16 Apr 2018

Mediterranean-style diet linked to greater gut microbial diversity, lower risk of hospitalization

A diet that is Mediterranean style, and rich in vegetables and fermented milk products such as yoghurt, along with coffee, tea and chocolate, is associated with greater gut microbial diversity and a lower risk of hospitalization in patients with liver cirrhosis, according to the results of an international study presented today at The International Liver Congress™ 2018 in Paris, France.

12 Apr 2018

New blood test may predict future heart disease risk

Despite heart disease and type 2 diabetes being among the leading causes of death in the U.S., the mechanisms leading to and linking these two diseases remain incompletely understood.

10 Apr 2018

Breast cancer survival linked to muscle mass finds study

Researchers have found that women with breast cancer who have a low muscle mass are less likely to survive stage 2 and 3 cancers. The study titled, “Association of Muscle and Adiposity Measured by Computed Tomography with Survival in Patients with Nonmetastatic Breast Cancer,” appears in the latest issue of the journal JAMA Oncology.

9 Apr 2018

Study uncovers mechanism causing chronic GVHD after bone marrow transplant

Allogeneic bone marrow transplant (BMT) is an essential treatment to cure patients with blood cancers such as leukemia. In patients who have undergone chemotherapy and radiation, a small number of cancer cells can remain in the bloodstream and allow the malignancy to recur.

3 Apr 2018

New PET imaging agent could help guide treatments for people with neurological diseases

Researchers have developed a new imaging agent that could help guide and assess treatments for people with various neurological diseases, including Alzheimer's, Parkinson's, and multiple sclerosis.

2 Apr 2018

Researchers find expression of lymphatic markers in proliferative diabetic retinopathy tissues

Proliferative diabetic retinopathy is a major sight-threatening diabetic complication. Nearly all patients with type I diabetes and over 60% of patients with type II diabetes develop retinopathy after 20 years of diabetes, despite metabolic control.

29 Mar 2018

Red and processed meat may increase the risk of liver disease

A new study has added non-alcoholic fatty liver disease to the list of chronic diseases associated with a high consumption of red and processed meat.

20 Mar 2018

Air pollution exposure during fetal life related to brain abnormalities, cognitive impairment in children

A new study performed in the Netherlands has linked exposure to residential air pollution during fetal life with brain abnormalities that may contribute to impaired cognitive function in school-age children. The study, published in Biological Psychiatry, reports that the air pollution levels related to brain alterations were below those considered to be safe.

8 Mar 2018

Study investigates use of drugs for the stomach and risk of major depressive disorder

A new study investigating the relationship between one of the commonest type of drugs used for protecting the stomach is presented in the current issue of Psychotherapy and Psychosomatics.

8 Mar 2018

UC receives $1.75 million grant for epilepsy research

Research scientist Jianxiong Jiang, PhD, doesn't just want to treat acquired epilepsy...he hopes to prevent it.

27 Feb 2018

Genetic variants make Asians and Europeans more prone to severe dengue

As globalization and climate change spread tropical infectious diseases around the globe, not all populations have the same degree of susceptibility.

23 Feb 2018

New clinical practice guideline provides recommendations for use of anticoagulants during heart surgery

The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiologists, and the American Society of ExtraCorporeal Technology released a new clinical practice guideline that includes major recommendations for the use of blood thinning medication (anticoagulants) during heart surgery.

22 Jan 2018