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Targeted Genetics announces new patent for Hyperlipidemia

Targeted Genetics Corporation announced today issuance of U.S. patent #6,887,463, entitled, "Methods and Compositions for Gene Therapy for the Treatment of Defects in Lipoprotein Metabolism."

11 May 2005

Researchers develop new method for facile identification of proteins in bacterial cells

Researchers at the Johns Hopkins Bloomberg School of Public Health have developed a new method for identifying specific proteins in whole cell extracts of microorganisms using traditional peptide mass fingerprinting (PMF).

4 May 2005

Myogen's Ambrisentan granted orphan drug designation by Europeans

Myogen today announced that the Commission of the European Communities, with a favorable opinion of the Committee for Orphan Medicinal Products of the European Medicines Agency (EMEA), has granted orphan drug designation to ambrisentan for the treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension.

2 May 2005

Physical activity appears to inhibit Alzheimer's

Physical activity appears to inhibit Alzheimer's-like brain changes in mice, slowing the development of a key feature of the disease, according to a new study.

26 Apr 2005

Generex Biotechnology receives Australian patent for vaccine technology to fight cancer and pandemic influenza

Generex Biotechnology announced today that its wholly owned subsidiary, Antigen Express, has received Australian Patent No. 778115 titled "Hybrid Peptides Modulate the Immune Response." Antigen Express is designing and testing such vaccine peptides for the control of cancer and infectious diseases with a particular focus on the pandemic H5N1 influenza, which has been reported in South East Asia.

26 Apr 2005

Researchers make gains in understanding antibiotic resistance

Howard Hughes Medical Institute researchers chiseling away at the problem of antibiotic resistance now have a detailed explanation of how the drugs' main cellular target in bacteria evolves to become resistant to some of these medications.

22 Apr 2005

Searching for the right pharmaceutical agent: survival as the indicator

Tumor cells divide fast. They thus require a high supply of components for their DNA, like purines. The biosynthesis of purines could now be a new point of attack for chemotherapy. However, without a natural model, the search for an inhibitor for a cellular process is like the proverbial search for a needle in a haystack. An American research team has developed a clever way to quickly conjure the desired "needle" out of the hay, presenting several candidates to act as starting points for the design of a purine synthesis inhibitor.

19 Apr 2005

Chemical library aids in developing drug system for nerve damage

A researcher studying drug design for nerve damage therapies has gotten her answer to questions by following some old advice: she used the library.

12 Apr 2005

Researcher grows new insulin-secreting beta cells from pancreatic tissue

JDRF-funded researchers in Canada and Massachusetts have stimulated the birth of new insulin-secreting beta cells by treating human islets with a mixture of two naturally occurring peptides: epidermal growth factor (EGF) and gastrin.

12 Apr 2005

New blood test improves the ability to diagnose or exclude congestive heart failure

A new blood test that measures a particular marker of cardiac distress can markedly improve the ability to diagnose or exclude congestive heart failure in patients with shortness of breath who come to hospital emergency departments.

11 Apr 2005

Process called sumoylation regulates key ion channel

Researchers at the University of Chicago have found that a recently discovered biological process known as sumoylation -- until now thought to be active only in the nucleus -- also occurs near the cell's surface where it regulates at least one and possibly many kinds of proteins, providing a novel target for the development of new drugs.

7 Apr 2005

Novel method to reduce cat allergic reactions

Scientists have discovered a novel method to reduce cat allergic reactions by topping up the immune cells responsible for controlling them.

6 Apr 2005

Study suggests that eating onions might help prevent bone loss and osteoporosis

Besides adding flavor to food, onions also may be good for your bones. Researchers at the University of Bern in Switzerland have identified a compound in the popular vegetable that appears to decrease bone loss in laboratory studies using rat bone cells.

5 Apr 2005

Men have a four times greater risk than women of developing abdominal aortic aneurysms

Men have a four times greater risk than women of developing abdominal aortic aneurysms, estimated to be the cause of death in 4 percent of people over the age of 65, but the mechanism for this higher incidence has remained unknown.

4 Apr 2005

Discovery could lead to new drug targets for heart disease

Mice with glowing green hearts have yielded the latest clue in the search for molecules involved in structural heart disease. Vanderbilt University Medical Center investigators found that blocking the activity of a single protein, called CaM kinase, in the mouse heart protects against the damaging effects of a heart attack.

30 Mar 2005

Cells that might be able to suppres cat allergies

In a paper in this month's premier open-access medical journal PLoS Medicine, Mark Larche and colleagues from Imperial College London describe a subset of cells that might be able to suppress cells that cause cat allergy.

29 Mar 2005

Key target for Foot-and-Mouth drug revealed

A complete picture of Foot-and-Mouth Disease's key replication enzyme could lead to the development of new drugs to control the disease without recourse to vaccination or slaughter, scientists report today.

21 Mar 2005

Link between a critical cancer pathway and an Epstein-Barr Virus (EBV) protein

Researchers at the University of Pennsylvania School of Medicine have identified a link between a critical cancer pathway and an Epstein-Barr Virus (EBV) protein known to be expressed in a number of EBV-associated cancers.

15 Mar 2005

Neuronal death and processing of Tau protein in Alzheimer’s Disease (AD)

In a research report recently published in the Journal of Alzheimer's Disease, published by IOS Press, a research group from the International School for Advanced Studies (ISAS\SISSA) in Trieste (Luisa Fasulo, Gabriele Ugolini e Antonino Cattaneo) showed that a processed form of tau protein induces neuronal death by apoptosis (programmed cell death) when expressed in cultured rat hippocampal neurons.

15 Mar 2005

Doctors may soon be able to diagnose multiple sclerosis (MS) with a simple blood test

New research by Wake Forest University Baptist Medical Center and colleagues suggests that one day, doctors may be able to diagnose multiple sclerosis (MS) with a simple blood test. The findings are reported in the current issue of the Journal of Molecular Neuroscience.

15 Mar 2005