Robert Ring, a researcher with the Wyeth Discovery Neuroscience group, said that perhaps the time is right for drugmakers to take a closer look at the important roles these two substances play inside the brain. The pharmaceutical industry has been very successful in developing medicines aimed at regulating the hormonal effects of these two pituitary hormones on peripheral systems. Pitocin, an oxytocin-like molecule, was developed and commonly used to induce contractions during birth. Similarly, vasopressin receptors in the kidney and vascular smooth muscle have been targeted for the treatment of heart failure and other diseases.
Patrice Collins, Medical Affairs, Astellas Pharmaceuticals Inc.
“Effects of a novel vasopressin V1a/V2 antagonist conivaptin on serum sodium concentration and effective water clearance in hyponatremia clinical trials.”