Peritonitis News and Research

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Peritonitis is an inflammation of the peritoneum, the serous membrane which lines part of the abdominal cavity and viscera. Peritonitis may be localized or generalized, and may result from infection (often due to rupture of a hollow organ as may occur in abdominal trauma or appendicitis) or from a non-infectious process.

Antifungal agent Itraconazole inhibits SARS CoV-2 in vitro

Itraconazole is a broad-spectrum antifungal agent that has been shown to have some in vitro activity against SARS-CoV-2 by a team of Belgian and German researchers.

16 Nov 2020

Study reveals new therapeutic approach for superbug infections

A research team led by Professor Hongzhe SUN, Chair Professor from the Department of Chemistry, Faculty of Science, in collaboration with Dr Pak-Leung HO, Director of the HKU Carol Yu Centre for Infection from the Department of Microbiology, Li Ka Shing Faculty of Medicine.

5 Nov 2020

Remdesivir metabolite GS-441524 inhibits SARS CoV-2 in mouse model, finds study

This new study titled, "Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model," was released online as a preprint on the bioRxiv* server, prior to undergoing the peer-review process.

2 Nov 2020

Study shows unique cardioprotective properties of an old drug

A drug costing less than 2 euros per dose could reduce the long term consequences of a heart attack, benefitting millions of patients. Metoprolol, a member of the beta-blocker class of drugs that has been in use for more than 40 years, has been found to have unique cardioprotective properties.

9 Oct 2020

Study on domestic cats and dogs in COVID-19+ households

A recent survey conducted by a team of scientists from France reveals that pets living with confirmed coronavirus disease 2019 (COVID-19) patients have a high prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. The study is currently available on the bioRxiv* preprint server.

23 Sep 2020

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Using mouse models, scientists have investigated the active plasma metabolite of remdesivir, GS-441 524, and hydroxychloroquine as possible drug candidates in COVID-19. The research shows GS-441 524 could be an effective therapeutic drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while at the same time discounting hydroxychloroquine as a reliable anti-viral.

20 Sep 2020

Study invalidates Ebselen and other broad-spectrum SARS-CoV-2 Mpro inhibitors

Other novel compounds with Mpro inhibitory activity have also been claimed to have antiviral activity. These include ebselen, disulfiram, tideglusib, carmofur, shikonin, and PX-12. A new research paper discusses the role of these molecules as potential Mpro inhibitors in the prevention of SARS-CoV-2 infection.

18 Sep 2020

Cat antiviral that inhibits SARS-CoV-2 fast-tracked for human clinical trials

Now, a team of researchers at the University of Alberta in Canada has identified viral inhibitors that they claim are potential candidates as a treatment for COVID-19. The team is set to launch clinical trials of the drug that is used as a treatment for a type of coronavirus in cats.

31 Aug 2020

Scientists identify compounds that block replication of COVID-19 virus

As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious respiratory virus.

7 Jul 2020

Examining the effect of smoking, nicotine and vaping on COVID-19 severity

Researchers at the University of Oxford say they will be conducting the most extensive study to date linking primary and clinical data for the assessment of associations between smoking status and the severity of coronavirus disease 2019 (COVID-19).

9 Jun 2020

Kawasaki disease outbreak in children with COVID-19

The ongoing COVID-19 pandemic has marched its way to almost all parts of the world, with hundreds of thousands of deaths and over 4.5 million cases as of May 15, 2020. One saving grace has been the apparent sparing of children, though the mortality in older people is quite high.

17 May 2020

Cat coronavirus drug shows promise for treatment of COVID-19

“They are strong drug candidates for the treatment of human coronavirus infections because they have already been successful in animals (cats),” writes the team. “The work here lays the framework for their use in human trials for the treatment of COVID-19.”

5 May 2020

Can cats and dogs catch or spread COVID-19?

A recent report from Hong Kong that two dogs had tested positive for the novel coronavirus SARS-CoV-2 had pet owners in a tizzy. This was compounded by news that a cat owned by a COVID-19 patient had developed symptoms of the illness in Belgium – such as breathing trouble and diarrhea – a week after the owner tested positive. The cat’s vomit and feces were subsequently found to be positive for the viral genome.

2 Apr 2020

Patient satisfaction and quality of life similar across all appendicitis treatments

A new study published in the journal JAMA Surgery in February 2020 shows that patients with acute appendicitis that were successfully treated either by antibiotics or by appendectomy had identical satisfaction with their treatment and identical quality of life over the long term. The patients who were first treated conservatively and then had appendectomy had lower satisfaction rates.

19 Feb 2020

'Watch-and-Wait' strategy may help rectal cancer patients to safely evade surgery

A team of doctors and scientists from the Champalimaud Clinical Centre in Lisbon, Portugal, and the Netherlands Cancer Institute in Amsterdam, has shown that patients with "low" rectal cancer (that is, very close to the anus) who show no sign of their tumors after a course of radio- and chemotherapy can safely choose to postpone invasive and complication-prone surgical procedures.

6 Feb 2020

Injecting nanoparticles into the bloodstream to reduce brain swelling after traumatic brain injury

After a traumatic brain injury, the most harmful damage is caused by secondary swelling of the brain compressed inside the skull. There is no treatment for this.

22 Jan 2020

Award to help advance development of diagnostic test for necrotizing enterocolitis

The Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health has awarded Chosen Diagnostics Inc, a spin-out company, a $299,641 Phase I Small Business Technology Transfer award.

9 Dec 2019

Study finds reliable biomarker for noninvasive detection of deadly infant disease

A diagnostic study of 136 premature infants found that a protein involved in managing harmful bacteria in the human intestine is a reliable biomarker for the noninvasive detection of necrotizing enterocolitis.

8 Nov 2019

Work in progress on medicine for treatment of ulcerative colitis

IKBFU center for clinical research scientists have participated in the international VARSITY clinical research. It's the world's first research aimed at finding the most effective drug among anti-inflammatory ones for the treatment of ulcerative colitis.

28 Oct 2019

How do gallstones form?

The human body is known to produce stones in various locations, most commonly in the kidneys, the bladder, the gallbladder and the appendix. Many of these stones appear without any obvious reason. However, a new study published in the journal Immunity shows the whole storyline for the first time: how gallstones are formed.

9 Oct 2019