Phase Contrast Microscopy News and Research

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Chlorine-releasing agents in clinical settings fail to combat Clostridioides difficile spores

The current study highlights the resistance of C. difficile spores to chlorine-releasing agents.

29 Nov 2023

Cephalopod + Tomocube = New formula for molecular probes

Researchers have discovered how to use the cephalopod proteins responsible for these changes to manipulate the optical RI of mammalian compartments.

From Tomocube Inc. 23 Sep 2020

Integrin-binding peptide ATN-161: Potential COVID-19 treatment

Now, a new study by researchers at Tulane University and published on the preprint server bioRxiv* in June 2020 reports the potential role of an integrin inhibitor ATN-161 to prevent ACE2-S protein binding.

17 Jun 2020

Anti-RBD antibodies shown to neutralize active SARS-CoV-2

A new study published on the preprint server bioRxiv* in June 2020 reports the discovery of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in samples from healthy donors, collected before the pandemic. These antibodies are capable of inhibiting the binding of the spike protein of the virus to the angiotensin-converting enzyme 2 (ACE2) molecule and can neutralize active infection of cells in culture.

9 Jun 2020

New method reveals how giant viruses infect amoeba

Host cells infected with giant viruses behave in a unique manner. To gain deeper insight into the infection mechanism of giant viruses, scientists at Tokyo University of Science developed a specialized algorithm that can track the movement of host cells.

23 Jan 2020

Researchers join new project to eliminate animal testing

Researchers at the University of California, Riverside, are part of an ambitious plan at the U.S. Environmental Protection Agency, or EPA, to eliminate animal testing by 2035.

19 Sep 2019

Tomocube HT microscope enables label-free quantification of cellular lipid content

In a breakthrough for research fields as diverse as diabetes, atherosclerosis and biofuels, the mass, concentration, volume, and surface area of individual lipid droplets have been measured in live, unstained cells for the first time using a Tomocube Holotomography microscope.

From Tomocube Inc. 12 Jul 2019

New laboratory test has potential to accurately predict spread of breast cancer

Researchers at The Johns Hopkins University and other institutions report that a new laboratory test that induces cancer cells to squeeze through narrow spaces has the potential to accurately predict which breast cancers and other solid tumors are likely to spread, or metastasize, to other sites.

From Johns Hopkins Medicine 29 May 2019

Holotomography (HT) technology used to image individual neurons

A Korean research team has demonstrated quantitative morphological profiling of individual neurons using Holotomography (HT) technology developed by Tomocube.

From Tomocube Inc. 14 Mar 2019

New microscope gives doctors better idea on safety and efficacy of medication

A new type of microscope may give doctors a better idea of how safely and effectively a medication will perform in the body.

28 Feb 2019

New artificial intelligence-based system to differentiate between different types of cancer cells

In cancer patients, there can be tremendous variation in the types of cancer cells from one patient to another, even within the same disease. Identification of the particular cell types present can be very useful when choosing the treatment that would be most effective, but the methods of doing this are time-consuming and often hampered by human error and the limits of human sight.

10 Dec 2018

Tomocube introduces new holotomography microscope for live cell imaging

A novel optical microscope utilizing diffraction tomography to generate 3D holographic images of unlabelled live cells is now available from Tomocube. Called HT-1, the new microscope delivers quantitative nanoscale, real-time, dynamic images of individual living cells quickly and simply without any sample preparation.

From Tomocube Inc. 25 Sep 2018

UCL researchers use ZEISS Xradia 810 Ultra X-ray microscopy to study batteries, fuel cells

The Electrochemical Innovation Laboratory at University College London is using ZEISS Xradia 810 Ultra X-ray microscopy to study the inner-workings of batteries and fuel cells.

From Carl Zeiss AG 14 Sep 2018

New discovery overturns centuries of thought about nature of kidney stones

A geologist, a microscopist and a doctor walk into a lab and, with their colleagues from across the nation, make a discovery that overturns centuries of thought about the nature and composition of kidney stones.

14 Sep 2018

Using Smartphones for Cancer Diagnosis and Management

Dr. Castro is a translational oncologist with experience developing and harnessing nanotechnology and molecular imaging platforms for cancer purposes. His work offers a “less is more” approach — to generate robust cancer analyses using scant amount of specimens. Dr. Castro’s research has included funding from the V Foundation for Cancer Research, National Institutes of Health, Ovarian Cancer Research Fund, and the Department of Defense.

From Pittcon 14 Feb 2018

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.

From Sartorius 5 Dec 2017

Olympus BX53 microscope delivers outstanding brightness and true-to-life images for life science applications

With an LED illuminator equivalent to a 100-watt halogen lamp, the Olympus BX53 microscope delivers outstanding brightness and true-to-life images. The BX53’s ergonomic design and ease of use make it an ideal system for clinical laboratories, while the LED illuminator’s brightness makes the system an excellent solution for multi-head teaching systems.

From Evident Corporation - Life Sciences 6 Jun 2017

CELENA™ S advanced imaging workflow solution released by Logos Biosystems

Logos Biosystems announced the launch of the new CELENA™ S Digital Imaging System with an onstage incubator. The multipurpose CELENA S is designed to simplify high-resolution fluorescence, brightfield, and phase contrast imaging for novices and experts alike.

From Logos Biosystems 20 Apr 2017

Using nanodiamonds to see smaller

Many of the most fundamental, life governing biological processes take place at size and time scales that remain invisible with current imaging technologies. Understanding how the molecules that underlie these processes move, interact and change could pave the way for new treatments, cures and the development of novel drug therapies.

7 Apr 2017

Exceptional user comfort during long periods of routine microscope observation from Olympus CX43 and CX33 microscopes

Ergonomic and easy to use, the new Olympus CX43 and CX33 microscopes help keep users comfortable during long periods of use, maximizing work efficiency.

From Evident Corporation - Life Sciences 3 Apr 2017