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New genomic tools provide better understanding of the human immune system

When the body is under attack from pathogens, the immune system marshals a diverse collection of immune cells to work together in a tightly orchestrated process and defend the host against the intruders.

22 Jan 2018

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, led by Dr. Àlex Vaquero, have proposed a new regulation mechanism of the NF-κB pathway, which is associated with accelerated cellular aging, based on the analysis of the function of the SirT6 protein.

19 Jan 2018

Prostate cancer’s gene-determined ‘immune landscape’ dictates tumor progression

The field of immunotherapy - the harnessing of patients' own immune systems to fend off cancer - is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

12 Jan 2018

Why Should We Weigh Every Protein in the Human Body?

Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level.

From Pittcon 5 Jan 2018

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

Research led by Ludwine Messiaen, Ph.D., professor of genetics at the University of Alabama at Birmingham, shows that missense mutations in a cluster of just five codons in the NF1 gene are an important risk factor for severe symptoms of the genetic disease neurofibromatosis type 1.

28 Dec 2017

Two studies show how cells adapt to stressors by reprogramming internal signaling networks

In a pair of publications, researchers have shown how cells adapt to stressors--like water loss--by reprogramming their internal signaling networks.

20 Dec 2017

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Understanding how cancer cells are able to metastasize -- migrate from the primary tumor to distant sites in the body -- and developing therapies to inhibit this process are the focus of many laboratories around the country.

18 Dec 2017

Gene that could be associated with reduced pain response found

Researchers found an Italian family, the Marsilis that have six individuals who respond significantly differently to pain than others. This includes a 78-year-old lady and her two daughters and their three children.

18 Dec 2017

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

Researchers have discovered a mechanism of resistance to checkpoint inhibitors and how to reverse it. The biomarker results from the IMvigor210 study are reported at the ESMO Immuno Oncology Congress 2017.

8 Dec 2017

Taurine could boost effectiveness of existing multiple sclerosis therapies

New research suggests that administering taurine, a molecule naturally produced by human cells, could boost the effectiveness of current multiple sclerosis (MS) therapies.

8 Dec 2017

Family members who do not carry inherited mutation have higher risk of melanoma

In families who carry certain inherited mutations that increase the risk for melanoma, members who do not carry the mutation also have an increased risk of melanoma, a study from Karolinska Institutet published in Genetics in Medicine reports.

8 Dec 2017

Severely preterm children with HRV have lower airway obstruction linked to retractions, wheezing

Human rhinovirus (HRV), the culprit behind most colds, is the leading cause of hospitalization for premature babies. However, in very preterm children, exactly how HRV causes severe respiratory disease -- and which patients may need more intensive observation and treatment -- is less well understood.

7 Dec 2017

Human sperm may hold potential to serve as biomarkers of future health

Human sperm may hold the potential to serve as biomarkers of the future health of newborn infants, according to a new study by a Wayne State University School of Medicine research team.

1 Dec 2017

Research suggests general mechanism by which dietary fats affect cellular physiology

You are what you eat when it comes to fat, report scientists from McGovern Medical School at The University of Texas Health Science Center at Houston in the journal Science Advances.

1 Dec 2017

Adults as likely to develop type 1 diabetes as children, research finds

Type 1 diabetes is not predominantly a 'disease of childhood' as previously believed, but is similarly prevalent in adults, new research published in the Lancet Diabetes & Endocrinology shows.

30 Nov 2017

Easy-to-use omics toolkit sets the stage for new era of biology and precision medicine

Most complex diseases, such as obesity, longevity, and diabetes, are largely influenced by genetic factors. But at the same time, they are also modulated by environmental stimuli, such as diet and physical activity.

29 Nov 2017

New strategy offers therapeutic alternative to prevent excessive clotting in kidney disease patients

Researchers at Boston University School of Medicine have discovered a potential treatment target to prevent chronic kidney disease patients from developing blood clots without causing bleeding complications - an unwanted and perplexing side effect.

29 Nov 2017

HCI researchers observe how breast cancer tumors evolve over time

A new study by researchers at Huntsman Cancer Institute at the University of Utah observed how breast cancer tumors evolve over time and demonstrated how changes within tumors may contribute to the process by which cancers no longer respond to treatment.

29 Nov 2017

Study finds specific tumor environment that stimulates cancer cells to metastasize

A new study, conducted by a team of researchers from the University of California, San Diego, has identified how the environment surrounding a tumor can stimulate metastatic behavior in the individual cancer cells. Researchers found that the tumor cells activate a particular set of genes and begin to form blood vessel-like structures when they are confined in a densely packed environment.

22 Nov 2017

Scientists discover how tumor environment can trigger metastatic behavior in cancer cells

A team of bioengineers and bioinformaticians at the University of California San Diego have discovered how the environment surrounding a tumor can trigger metastatic behavior in cancer cells.

22 Nov 2017

Phenotype News and Research

New genomic tools provide better understanding of the human immune system

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Prostate cancer’s gene-determined ‘immune landscape’ dictates tumor progression

Why Should We Weigh Every Protein in the Human Body?

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

Two studies show how cells adapt to stressors by reprogramming internal signaling networks

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Gene that could be associated with reduced pain response found

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

Taurine could boost effectiveness of existing multiple sclerosis therapies

Family members who do not carry inherited mutation have higher risk of melanoma

Severely preterm children with HRV have lower airway obstruction linked to retractions, wheezing

Human sperm may hold potential to serve as biomarkers of future health

Research suggests general mechanism by which dietary fats affect cellular physiology

Adults as likely to develop type 1 diabetes as children, research finds

Easy-to-use omics toolkit sets the stage for new era of biology and precision medicine

New strategy offers therapeutic alternative to prevent excessive clotting in kidney disease patients

HCI researchers observe how breast cancer tumors evolve over time

Study finds specific tumor environment that stimulates cancer cells to metastasize

Scientists discover how tumor environment can trigger metastatic behavior in cancer cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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