Phosphorylation News and Research

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Health effects of passive somking studied in first-of-a-kind clinical study

Until bans on in-flight smoking took effect, beginning in 1988, flight attendants were regularly exposed to secondhand smoke.

1 Feb 2007

New tool to study protein kinase A - linked to heart failure

Scientists studying heart cells have devised a new way to visualize and quantify the rise and fall in the activity of a key enzyme linked to heart failure.

8 Aug 2006

Nicotine promotes growth of established tumors

While it is established that nicotine by itself is not carcinogenic, researchers have now shown that nicotine promotes cell proliferation and the progression of tumors already initiated by tobacco carcinogens.

24 Jul 2006

Altered activity in receptor pair points to further complexity in schizophrenia pathology

Researchers at the University of Pennsylvania School of Medicine, in collaboration with scientists at the City University of New York, have identified a striking dysregulation in neuronal receptor activity in the postmortem brain tissue from patients with schizophrenia.

18 Jun 2006

Protein called Elk-1appears to play role in neurodegeneration and schizophrenia

Pprotein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein - typically active in the nucleus - could play a role in cell death and mitochondria-related diseases such as neurodegeneration and schizophrenia.

9 Jun 2006

New data show Enzastaurin's activity across multiple cancer cell lines

Eli Lilly and Company's enzastaurin, an investigational, multi-targeted therapy that is currently the focus of two global Phase III clinical trials, one for the treatment of glioblastoma and one in non-Hodgkin's lymphoma

5 Jun 2006

Cause of neurodegeneration in Huntington's disease discovered

The severe neurodegeneration associated with Huntington's disease may result from molecular mutations that block the transport of nutrients within cells.

1 Jun 2006

New understanding of chromosomal glue

Researchers have a new understanding of the process cells use to ensure that sperm and eggs begin life with exactly one copy of each chromosome - a process that must be exquisitely regulated to prevent problems such as miscarriages and mental retardation.

8 May 2006

Scientists clarify role of phosphatase and tensin homolog tumor suppressor gene

Jiwang Zhang, Ph.D., formerly a Senior Research Associate at the Stowers Institute for Medical Research, and Linheng Li, Ph.D., Associate Investigator, are credited as the first and last authors, respectively, on a paper highlighting several previously unknown functions of phosphatase and tensin homolog (PTEN), an important tumor suppressor gene.

23 Apr 2006

Targeted mutations in mice uncover two key molecular events linked to learning

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells.

11 Apr 2006

Promising new targets for Alzheimer's drug therapies

An enzyme previously associated with preventing the dementia of Alzheimer's disease now appears to play an even bigger role in safeguarding against the disease, bringing the promise of new targets for drug therapies.

4 Apr 2006

New mechanism that regulates K-Ras - protein that plays an important role in cancer

Researchers have discovered a protein widely known to cause the out-of-control growth of cells can actually be manipulated to induce those cells to commit suicide, providing a novel target for the development of anti-cancer drugs, according to the results of a new study led by New York University School of Medicine researchers.

21 Feb 2006

Protein finding could lead to new topical treatment for inflammatory diseases

A protein that undesirably shields a skin poxvirus from the immune system may become the key ingredient in a new topical treatment for inflammatory diseases, say medical researchers at the University of Illinois at Urbana-Champaign.

11 Jan 2006

Findings may help in development of new anti-inflammatory compounds

Virginia Commonwealth University researchers studying the enzyme that triggers inflammation have found that it may be a target for a new class of anti-inflammatory drugs to treat arthritis, asthma, multiple sclerosis, lung and colon cancers and Alzheimer's disease.

2 Dec 2005

Discovery of agent that can suppress cancer development

In a case of basic science detective work, researchers at The University of Texas M. D. Anderson Cancer Center have solved the puzzle of the "inconsistent biomarker" and, in the process, may have discovered an agent that can suppress cancer development.

13 Oct 2005

Vanadium may help prepare the body to recover speedily from infections

Dietary supplements containing vanadium are used by body builders to help beef up muscles and by some diabetic people to control blood sugar. New research now suggests the naturally occurring but easily toxic element may help prepare the body to recover speedily from infections from gram-negative organisms such as E. coli.

11 Oct 2005

Ubiquitin ligase Rnf6 may be involved in oncogenesis

In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons.

3 Oct 2005

Nanogen issued patent relating to biological screening device

Nanogen announced today it was issued Patent No. 6,942,778, "Microstructure Apparatus and Method for Separating Differently Charged Molecules Using an Applied Electric Field" by the U.S. Patent and Trademark Office.

26 Sep 2005

New findings suggest balancing Chk1 activity will produce less toxic cancer drugs

A study published by The Burnham Institute in the September edition of Molecular Cell reports that a cell-cycle checkpoint protein, known to be activated by an important class of anticancer drugs, may play crucial roles in both the hampering of therapeutic actions and aiding cancer cells to "recover" and start dividing again after treatment with these drugs.

5 Sep 2005

Discovery of new gene FANCM sheds light on repair of damaged DNA

National Institute on Aging (NIA) researchers have discovered a new gene, FANCM, which sheds light on an important pathway involved in the repair of damaged DNA.

22 Aug 2005