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Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

In a recent study posted to the medRxiv*preprint server, a team of researchers from Israel developed and validated novel reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR) assays. The new assays enable the rapid and high throughput identification and differentiation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 and BA.2 variants.

8 Mar 2022

Higher SARS-CoV-2 load in morning-collected samples

In a recent study posted to the medRxiv* preprint server, researchers identified that morning-collected nasal and saliva samples yielded better detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially in tests with low to moderate analytical sensitivity.

8 Mar 2022

Bacterial coinfection pervasiveness and antibiotic use in COVID-19 patients

In a recent study posted to the medRxiv* pre-print server, researchers conducted a meta-analysis to determine the bacterial coinfection and antibiotic usage prevalence in coronavirus disease 2019 (COVID-19) patients.

7 Mar 2022

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Researchers from Columbia Engineering, Fiocruz's Center for Technological Development in Health and the Oswaldo Cruz Institute in Brazil, Memorial Sloan Kettering Cancer Center, and Rockefeller University recently reported that, by combining inhibitors of polymerases and exonucleases--enzymes that allow SARS-CoV-2 to reproduce--they were able to reduce SARS-CoV-2 replication 10 times more than when using just the polymerase inhibitors.

7 Mar 2022

Delta and Omicron coinfections identified in France

A new study shows both the Omicron and Delta variants were able to infect patients with healthy immune function.

7 Mar 2022

NETosis in COVID-19 and MIS-C

A new study investigates the role played by neutrophil extracellular traps formation and degradation in COVID-19.

7 Mar 2022

Study explores differentially expressed immune genes for COVID-19 patient stratification

In a new study, researchers determined the transcriptional signatures associated with the severity of COVID-19.

7 Mar 2022

Exploring biomedical literature and clinical trial records to identify new drug combinations for COVID-19 treatment

Researchers extensively searched publicly available SARS-CoV-2 biomedical literature to identify drug combinations that could effectively treat COVID-19.

7 Mar 2022

Common rapid antigen tests detect Delta and Omicron SARS-CoV-2 strains effectively

A recent study by US researchers shows how the performance of rapid antigen tests to diagnose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not inferior among individuals infected with the Omicron variant compared to the Delta variant. The study is currently available on the medRxiv* preprint server while it undergoes peer review.

7 Mar 2022

How does COVID-19 affect patients with idiopathic pulmonary fibrosis?

A new study discusses the outcomes of idiopathic pulmonary fibrosis patients with confirmed SARS-CoV-2 infection.

6 Mar 2022

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

A recent study explores the effect of sleep and circadian rhythm dispersion on mouse lung transcriptome after six of hours sleep deprivation.

6 Mar 2022

Omicron-specific mRNA vaccine generates immune responses in mice, hamsters and Macaques

Researchers develop an Omicron variant mRNA vaccine that is be more potent in generating nAbs as compared to other available vaccines.

6 Mar 2022

Dynamics of SARS-CoV-2 transmission at Purdue University

Researchers performed genomic surveillance of SARS-CoV-2 and its variants in a university setting.

4 Mar 2022

Gas chromatography-ion mobility spectrometry helps diagnose COVID-19 and predict disease severity

Researchers assess the ability of GC-IMS to differentiate between COVID-19 and other respiratory infections, as well as predict disease severity.

4 Mar 2022

RT-LAMP assay shows promise as point-of-care SARS-CoV-2 detection assay across multiple settings

Researchers evaluate the feasibility and robustness of an optimized RT-LAMP SARS-CoV-2 detection assay across multiple resource-restricted settings.

4 Mar 2022

Clinical trial report endorses nitazoxanide as a safe drug for moderately ill COVID-19 patients

Researchers tested the safety and efficacy of 600 mg oral dose of nitazoxanide in mild or moderately ill COVID-19 patients.

3 Mar 2022

Study shows targeting DDX3 with RK-33 reduced the viral load in four isolates of SARS-CoV-2

A new study has focused on developing a novel anti-SARS-CoV-2 therapy using HTA directed against the human host DEAD-box RNA helicase.

3 Mar 2022

Infection with Omicron sub-lineage BA.1 protects from reinfection against BA.2 sub-lineage and vice-versa

Researchers found that infection with one Omicron sub-lineage of SARS-CoV-2 induces strong protection against reinfection with the other Omicron sub-lineage.

3 Mar 2022

Study explores coronavirus surveillance in bats from Argentina

In a new study, researchers monitored the circulation of coronaviruses in bats from the central and northern provinces of Argentina.

3 Mar 2022

Scientists find no connection between pandemic chilblains and SARS-CoV-2 infection

A recent study provides a better understanding of whether SARS-CoV-2 infection is linked with the occurrence of chilblains.

3 Mar 2022

Polymerase News and Research

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

Higher SARS-CoV-2 load in morning-collected samples

Bacterial coinfection pervasiveness and antibiotic use in COVID-19 patients

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Delta and Omicron coinfections identified in France

NETosis in COVID-19 and MIS-C

Study explores differentially expressed immune genes for COVID-19 patient stratification

Exploring biomedical literature and clinical trial records to identify new drug combinations for COVID-19 treatment

Common rapid antigen tests detect Delta and Omicron SARS-CoV-2 strains effectively

How does COVID-19 affect patients with idiopathic pulmonary fibrosis?

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

Omicron-specific mRNA vaccine generates immune responses in mice, hamsters and Macaques

Dynamics of SARS-CoV-2 transmission at Purdue University

Gas chromatography-ion mobility spectrometry helps diagnose COVID-19 and predict disease severity

RT-LAMP assay shows promise as point-of-care SARS-CoV-2 detection assay across multiple settings

Clinical trial report endorses nitazoxanide as a safe drug for moderately ill COVID-19 patients

Study shows targeting DDX3 with RK-33 reduced the viral load in four isolates of SARS-CoV-2

Infection with Omicron sub-lineage BA.1 protects from reinfection against BA.2 sub-lineage and vice-versa

Study explores coronavirus surveillance in bats from Argentina

Scientists find no connection between pandemic chilblains and SARS-CoV-2 infection

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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