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Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

With this background, the goal of a new study published on the bioRxiv* preprint server was to use cryo-electron microscopy to investigate the nsp13 helicase conformational states in order to gain insights of how nsp13 functions during viral transcription/replication.

16 Nov 2021

Identification of transcription regulatory sequences and genes in previously unannotated coronaviruses

Scientists have hypothesized that the presence of regulatory sequences could be effectively used to instantaneously and accurately identify TRS sites as well as the related viral genes in unannotated coronavirus genomes.

16 Nov 2021

Targeted proteomics for detection of SARS-CoV-2 proteins in clinical samples

A team of researchers from various institutions within the Netherlands examined the use of targeted MS-based proteomics for the detection of SARS-CoV-2 in research and clinical samples.

16 Nov 2021

COVID-19 fatality disparities among working class in California

A recent study evaluates whether there is any correlation between the victims of COVID-19 and their occupation.

15 Nov 2021

Rapid thermal cycling approach for the detection of SARS-CoV-2

Researchers develop an ultrafast detection method for SARS-CoV-2 by direct RT-PCR without RNA extraction that is suitable for large-scale use.

15 Nov 2021

Immune response elicited by SARS-CoV-2 vaccines in infliximab and vedolizumab-treated patients with IBD

A recent study evaluates the immune responses elicited by COVID-19 vaccines in infliximab- or vedolizumab-treated IBD patients.

15 Nov 2021

Study identifies a host factor that reflects different levels of inflammation within mild COVID-19 cases

A new study investigates serum from COVID-19 convalescents and uninfected individuals to determine the molecular mechanisms of host responses.

15 Nov 2021

Research expands the general understanding of transcription process in bacteria

Bacteria need to constantly adapt to compete against other species for nutrient sources and to survive against threats such as antibiotics and toxins.

15 Nov 2021

Could drugs derived from microalgae be effective against COVID-19?

Researchers discuss the ability of some microalgae metabolites to prevent cytokine storm syndrome during COVID-19.

15 Nov 2021

SARS-CoV-2 infection inhibited by CCR2 signaling

A new study discusses the role of monocytes in protecting individuals from SARS-CoV-2.

15 Nov 2021

Public health strategies associated with reduced SARS-CoV-2 transmission in Switzerland

The current study attempts to estimate the quantitative effects of specific measures, using a combination of phylogenetic and phylodynamic approaches.

15 Nov 2021

Standard PCR tests do not pick up new Covid strains, warns expert

Some new strains of Covid-19 are not being picked up by standard PCR tests, reveals leading testing expert Dr Quinton Fivelman. He warns that new mutations mean some variants are not being picked up by the standard, widely-used, single gene tests.

15 Nov 2021

Detection of a coronavirus similar to SARS-CoV-2 in Cambodian bats

Now, a new study published in the journal Nature Communications reports the identification of SARS-CoV-2 related coronaviruses in two horseshoe bats sampled in Cambodia in 2010.

15 Nov 2021

The case for vaccinating children under 12 against COVID-19

Researchers assess the need for coronavirus disease 2019 (COVID-19) vaccination in children who are 12 years of age or younger.

14 Nov 2021

Xanthohumol as a potent pan-inhibitor for various coronaviruses

Researchers from China reported the results of their study aimed at finding an effective Mpro inhibitor since Mpro is the best drug target to fight SARS-CoV-2 infection.

12 Nov 2021

Analysis of immunodeficient patients granted REGEN-COV under compassionate use COVID-19 program

A team of scientists describe the safety and response to REGEN-COV® for COVID-19 patients with immunodeficiency-associated antibody disorders.

11 Nov 2021

RT-LAMP coupled solid-state nanopores for SARS-CoV-2 detection

Researchers discuss a highly sensitive, specific, and rapid SARS-CoV-2 detection platform by coupling the RT-LAMP with glass nanopore sensors.

11 Nov 2021

Long-term effectiveness of Pfizer/BioNTech two-dose regimen mRNA vaccine

A group of scientists from Israel sought to evaluate the long-term effectiveness of the BioNTech/Pfizer mRNA BNT162b2 vaccine.

11 Nov 2021

Surveillance approaches to monitor the presence of SARS-CoV-2 in a fully vaccinated population

Researchers at the University of Calgary Health Technology Assessment Unit investigated scientific evidence on various surveillance and testing methods to monitor the presence of the virus in a vaccinated population.

10 Nov 2021

New discovery could lead to the creation of a pan-coronaviruses vaccine

Next generation vaccines for Covid-19 should aim to induce an immune response against 'replication proteins', essential for the very earliest stages of the viral cycle, concludes new research carried out by UCL scientists.

10 Nov 2021