Prion Disease News and Research

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Oral vaccine prevents prion disease in mice

An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research presented at the American Academy of Neurology's 59th Annual Meeting in Boston.

4 May 2007

Disease associated prion protein oligomers inhibit the 26S proteasome

The rogue prion proteins responsible for diseases like BSE and vCJD can destroy brain cells by blocking the protein recycling process that helps keep cells healthy.

27 Apr 2007

UK scientists reverse symptoms of mad cow disease

The researchers at University College, London, believe they have found a way to treat the disease in humans as long as it is detected before it has done harm to a large number of brain cells.

1 Feb 2007

Effects of prion disease could be reversed if caught early enough

The researchers said that their findings support developing early treatments that aim to reduce levels of prion protein in the brains of people with prion disease.

31 Jan 2007

Single protein plays a major role in prion diseases

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

23 Jan 2007

Fat droplets play protective role inside cells

Too much body fat may be a bad thing, but there is increasing evidence that too little fat also may have some surprisingly negative consequences.

19 Sep 2006

New aspect of prion disease - agent causes heart damage

Until now, prion disease has been thought of as a chronic neurological condition.

9 Jul 2006

New discovery boosts basic understanding of prion infections

Brittleness is often seen as a sign of fragility. But in the case of infectious proteins called prions, brittleness makes for a tougher, more menacing pathogen.

28 Jun 2006

No prion diseases found in German deer

Presently, there is no evidence of prion diseases in free-living German cervids.

19 Jun 2006

Certain soil types serve as natural prion repositories in the wild

Scientists have confirmed that prions, the mysterious proteins thought to cause chronic wasting disease (CWD) in deer, latch on tightly to certain minerals in soil and remain infectious.

18 Apr 2006

Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life.

4 Apr 2006

New evidence questions the simple link between prion proteins and vCJD

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life.

30 Mar 2006

New way of targeting proteins to exosomes - potential for melanoma, Alzheimer's disease

Researchers at the University of Pennsylvania School of Medicine have discovered how a protein called Pmel17 is sorted by pigment cells in the skin and eye to make a fiber matrix that eventually sequesters melanin, the dark pigment found in skin, hair, and eyes.

28 Mar 2006

New test for detecting small amounts of proteins in the blood

Researchers at the University of Pennsylvania School of Medicine have developed a paradigm-shifting method for detecting small amounts of proteins in the blood.

13 Mar 2006

Genesis bioventures announces worldwide distribution rights for rapid prion-detection technology

Genesis Bioventures, Inc. has announced that the Company has signed exclusive worldwide sales, marketing and distribution agreements with Prion Developmental Laboratories Inc. (PDL) to commercialize the recently patented Rapid Prion-Detection Assay tests developed by PDL.

7 Feb 2006

Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia

Most people with a rare type of dementia called primary progressive aphasia (PPA) have a specific combination of prion gene variants, a new study shows.

28 Nov 2005

Chronic Wasting Disease in deer and humans

Researchers at Binghamton University have a first-ever opportunity to determine if Chronic Wasting Disease (CWD) in deer can be spread to humans who ingest "infected" meat.

26 Nov 2005

Resveratrol effective in lowering amyloid-beta peptides

A study published in the November 11 issue of the Journal of Biological Chemistry shows that resveratrol, a compound found in grapes and red wine, lowers the levels of the amyloid-beta peptides which cause the telltale senile plaques of Alzheimer's disease.

7 Nov 2005

Scientists characterize the most infectious prion protein particles

A new study of prions - apparently malformed proteins that initiate deadly brain diseases such as Creutzfeldt-Jakob disease in humans - has yielded surprising information about how the size of prions relates to their infectivity.

10 Sep 2005

Adlyfe receives award from the development of blood test for animal prion diseases

Adlyfe, Inc., a privately held biotech company headquartered in Rockville, MD, focused on early diagnostics for animal and human brain diseases announced the award today of a $650,000 two year grant from the Department of Environment, Food and Rural Affairs (DEFRA) in the UK for continued development of a sensitive early blood test for animal prion diseases.

7 Sep 2005