Progressive Supranuclear Palsy News and Research

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Researchers explore multi-syndrome prediction of dementia syndromes

A new study explored how support vector machines (SVMs) applied to magnetic resonance imaging (MRI) data can differentiate different dementia syndromes.

16 Jan 2023

Targeting defective tau proteins may be needed to treat Alzheimer’s patients

In November, researchers reported the drug lecanemab slowed the progression of Alzheimer's disease. The effect was modest, but it has generated tremendous excitement because it was the first time a drug had been shown to be able to affect the course of this relentless, incurable disease.

26 Dec 2022

Possibility of the first fluid biomarker that reflects brain pathology in primary tauopathies

Addressing this gap in research, a recent Nature Medicine study hypothesized that 4R isoform-specific MTBR-tau species accumulate in the patient’s brain of specific subtypes of 4R tauopathies.

28 Nov 2022

New biomarker can help identify people with a primary tauopathy

Zooming in on a single disease and studying it intensely is often the most productive route to finding treatments. But there's no easy way to distinguish among people living with any of the primary tauopathies -; a group of rare brain diseases marked by rapidly worsening problems with thinking and movement -; because the symptoms are too similar.

24 Nov 2022

Combination of new testing methods helps identify multiple dementia risk genes

A new UCLA-led study has identified multiple new risk genes for Alzheimer's disease and a rare, related brain disorder called progressive supranuclear palsy (PSP) by using a combination of new testing methods allowing for mass screening of genetic variants in a single experiment.

18 Aug 2022

New center aims to accelerate research into biomarkers of neurodegenerative diseases

A new center established at Washington University School of Medicine in St. Louis aims to accelerate research into biomarkers of neurodegenerative conditions such as Huntington's and Parkinson's diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and the so-called tauopathies, a group that includes Alzheimer's disease along with rarer diseases such as frontotemporal dementia, corticobasal syndrome and progressive supranuclear palsy.

13 Jul 2022

Ultra-high strength 7T MRI scanner offers hope for treating cognitive symptoms in Parkinson’s patients

Ultra-powerful 7T MRI scanners could be used to help identify those patients with Parkinson's disease and similar conditions most likely to benefit from new treatments for previously-untreatable symptoms, say scientists.

17 May 2022

New deep learning method aids in the accurate diagnosis of parkinsonian diseases

A new deep learning method has been created to aid in the diagnosis of parkinsonian diseases, according to research published ahead of print by The Journal of Nuclear Medicine.

21 Apr 2022

Inhibiting key signaling pathway in immune cells may slow down Alzheimer's disease

Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer's and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators.

14 Apr 2022

Study: Targeting astrocytes reduces tau-related brain damage and inflammation in mice

Alzheimer's disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau.

18 Mar 2022

Skin biopsy can aid in early identification and differential diagnosis of Parkinson's disease

The diagnosis of Parkinson's disease (PD) is currently based on consensus clinical criteria. A novel study reported in the Journal of Parkinson's Disease has found that the presence of neuronal deposits of the biomarker phosphorylated alpha-synuclein (p-syn) in the brain and the skin of patients with PD distinguishes them from individuals with symptoms of parkinsonism due to the accumulation of another protein, tau.

15 Mar 2022

Cell-hobbling fibrils found across diverse neurodegenerative diseases

Take a cell-deep tour of a brain afflicted with Alzheimer's disease, and you will find minuscule clumps of protein that seem suspicious. Ever since the 1980s, when neuroscientists began identifying these protein tangles, researchers have discovered that other brain diseases have their own tangled-protein signatures.

4 Mar 2022

Researchers uncover new findings about the role of tau in neurodegenerative disease

Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the "tau interactome" uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons.

20 Jan 2022

Alzheimer's disease develops in a very different way than previously thought

For the first time, researchers have used human data to quantify the speed of different processes that lead to Alzheimer's disease and found that it develops in a very different way than previously thought.

30 Oct 2021

Study may lead to new treatments for a wide range of neurological conditions

New research published today sheds important light on how the production of a key protein in the brain is controlled, which could pave the way for new treatments for a wide range of neurological conditions.

19 May 2021

Study may help to better understand the pathological process involved in brain diseases

A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer's disease and several other neurodegenerative disorders.

1 Dec 2020

Progressive Supranuclear Palsy News and Research

Researchers explore multi-syndrome prediction of dementia syndromes

Targeting defective tau proteins may be needed to treat Alzheimer’s patients

Possibility of the first fluid biomarker that reflects brain pathology in primary tauopathies

New biomarker can help identify people with a primary tauopathy

Combination of new testing methods helps identify multiple dementia risk genes

New center aims to accelerate research into biomarkers of neurodegenerative diseases

Ultra-high strength 7T MRI scanner offers hope for treating cognitive symptoms in Parkinson’s patients

New deep learning method aids in the accurate diagnosis of parkinsonian diseases

Inhibiting key signaling pathway in immune cells may slow down Alzheimer's disease

Study: Targeting astrocytes reduces tau-related brain damage and inflammation in mice

Skin biopsy can aid in early identification and differential diagnosis of Parkinson's disease

Cell-hobbling fibrils found across diverse neurodegenerative diseases

Researchers uncover new findings about the role of tau in neurodegenerative disease

Alzheimer's disease develops in a very different way than previously thought

Study may lead to new treatments for a wide range of neurological conditions

Study may help to better understand the pathological process involved in brain diseases

Scientists unlock crucial molecular details regarding tau's activity

Nearly $4 million to fund drug discovery research for Alzheimer's, other dementia

Link found between genetic variations and size of the brainstem, other subcortical structures

New test could detect abnormal forms of protein associated with tauopathies

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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