Proliferation News and Research

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Androgen receptor signaling found to upregulate gene driving melanoma severity in men

Method by which androgen-activated androgen receptors (ARs) increase fucosyltransferase 4 (FUT4) expression.

12 Feb 2024

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

Targeting senescent cells in the retina with a BCL-xL inhibitor shows promise as a durable treatment for diabetic macular edema, potentially offering long-term visual function improvements.

8 Feb 2024

New mouse model illuminates lung cancer's transformation into aggressive variant

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment.

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

New study sheds light on sex differences in allergic airway inflammation

Researchers explored how sex hormones and chromosomes influence allergic inflammation and gene expression in four-core genotype (FCG) mice exposed to house dust mites (HDMs).

7 Feb 2024

Hydrogel with built-in antibiofilm and antioxidative functions promotes faster healing of infected chronic wounds

A novel hydrogel dressing was developed recently to combat both these undesirable characteristics and tested for its effects on diabetic-infected wound healing.

5 Feb 2024

Study links specific inflammatory markers to increased cancer risk

The causal relevance of circulating inflammatory markers in cancer risk.

5 Feb 2024

Black garlic may have anti-cancer and anti-inflammatory properties

The anti-inflammatory and anti-cancer properties of black garlic (BG).

5 Feb 2024

Researchers find new clue to treating aggressive Wilms tumor subtype

An international team, led by researchers at Nagoya University in Japan, may have determined why the diffuse anaplasia (DA) subtype of Wilms tumor (WT) resists chemotherapy.

2 Feb 2024

The effectiveness of statins in PCOS management

The application of statins in the treatment of polycystic ovary syndrome (PCOS).

1 Feb 2024

Immune protein Ku70 key in fighting bowel cancer

Study establishes Ku70's role in tumor suppression, showing that reduced expression or mutations in this DNA repair protein significantly increase intestinal cancer risk.

30 Jan 2024

Oncofetal ecosystems linked to recurrence and immunotherapy response in liver cancer

A team of clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS), Agency for Science, Technology and Research (A*STAR), the Harry Perkins Institute of Medical Research and global research partners, has found a causal link between the presence of oncofetal ecosystems (re-emergence of fetal programme/features driven by the tumor) in the primary liver cancer hepatocellular carcinoma (HCC) and cancer recurrence and response to immunotherapy.

29 Jan 2024

Exploring pharmacological, non-pharmacological, and stem cell therapies for treatment of autism spectrum disorders

A research study, led by Maurizio Battino and Francesca Giampieri, with a group of researchers from the Universidad Europea del Atlántico (European University of the Atlantic, UNEATLANTICO), published in the journal "Pharmacological Research", studies various pharmacological, non-pharmacological, and stem cell therapies for the treatment of autism spectrum disorders.

27 Jan 2024

Research upends understanding of circadian clock in melanoma

A Ludwig Cancer Research study has found that the circadian clock-;which synchronizes physiological and cellular activities with the day-night cycle and is generally thought to be tumor suppressive-;in fact has a contextually variable role in cancer.

27 Jan 2024

Sclerostin may protect against heart disease in patients with type 2 diabetes

A study carried out by the MP20-Biomarkers of Metabolic and Bone Diseases research group at the Biohealth Research Institute in Granada (ibs.GRANADA), led by UGR Professor Manuel Muñoz Torres, has provided significant insights into the role of sclerostin in protecting against atherosclerosis in patients with type 2 diabetes.

26 Jan 2024

Mayo Clinic unveils "secret gene" key to reversing heart failure in some patients

Mayo Clinic researchers studying the genetics of people who had recently developed dilated cardiomyopathy, one of the most common causes of heart failure, have found a particular gene to target for developing future drug therapy treatments.

24 Jan 2024

Mutations found in skin cancers could be harnessed to mend broken hearts

Biomedical engineers at Duke University have demonstrated that one of the most dangerous mutations found in skin cancers might moonlight as a pathway to mending a broken heart.

24 Jan 2024

LTBR identified as potential target for cancer immunotherapy and marker of poor prognosis

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, "Systematic analysis of the prognostic value and immunological function of LTBR in human cancer."

23 Jan 2024

Immune checkpoint inhibitor target found to promote skin cancer growth

Programmed cell death 1 (PD-1) is an important target for immune checkpoint inhibitor therapies that block its signaling and boost T-cell activity. PD-1 inhibitors have been approved for treating various types of cancer.

19 Jan 2024

Ludwig scientists deconstruct the blood supply of brain metastases

A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue, illuminating how they help shape the internal environment of tumors to support cancer growth and immune evasion.

19 Jan 2024

Proliferation News and Research

Androgen receptor signaling found to upregulate gene driving melanoma severity in men

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

New mouse model illuminates lung cancer's transformation into aggressive variant

Monash-led study unveils potential long-term treatment for lupus

New study sheds light on sex differences in allergic airway inflammation

Hydrogel with built-in antibiofilm and antioxidative functions promotes faster healing of infected chronic wounds

Study links specific inflammatory markers to increased cancer risk

Black garlic may have anti-cancer and anti-inflammatory properties

Researchers find new clue to treating aggressive Wilms tumor subtype

The effectiveness of statins in PCOS management

Immune protein Ku70 key in fighting bowel cancer

Oncofetal ecosystems linked to recurrence and immunotherapy response in liver cancer

Exploring pharmacological, non-pharmacological, and stem cell therapies for treatment of autism spectrum disorders

Research upends understanding of circadian clock in melanoma

Sclerostin may protect against heart disease in patients with type 2 diabetes

Mayo Clinic unveils "secret gene" key to reversing heart failure in some patients

Mutations found in skin cancers could be harnessed to mend broken hearts

LTBR identified as potential target for cancer immunotherapy and marker of poor prognosis

Immune checkpoint inhibitor target found to promote skin cancer growth

Ludwig scientists deconstruct the blood supply of brain metastases

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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