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Researchers receive NCI grant to study role of collagens in breast cancer

An MUSC Hollings Cancer Center researcher received a $3 million grant from the National Cancer Institute to study how patterns of collagens can serve as biomarkers of breast cancer risk and potentially reveal clues to what might be driving health disparities.

1 Oct 2020

New drug candidate suppresses SARS-CoV-2 replication

Researchers at Stanford University and Utah State University have developed a novel inhibitor of the coronavirus main protease (Mpro) that effectively suppresses the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Sep 2020

Scientists unlock crucial molecular details regarding tau's activity

Frontotemporal lobar degeneration (FTLD) is a type of dementia that appears earlier in life than Alzheimer's disease (AD).

15 Sep 2020

Single dose nasal vaccine against SARS-CoV-2 shows promise in animal studies

Now researchers at the Washington University School of Medicine in St. Louis have worked on developing a candidate vaccine against the infection that could be administered in a single dose via a nasal spray rather than an injection. In their preliminary studies using lab mice, this single dose of the nasal vaccine successfully prevented the infection with the novel coronavirus.

24 Aug 2020

Speed of Novavax vaccine development does not compromise quality of the SARS-CoV-2 immunogen

A new study by researchers from the Scripps Research Institute and Novavax Inc. in the US affirms the structural integrity of the full-length SARS-CoV-2 spike glycoprotein immunogen. It enables the interpretation of immune responses to this multivalent nanoparticle immunogen. Their results are currently available on bioRxiv preprint server.

9 Aug 2020

Stabilized prefusion spike vaccine candidate induces powerful immune response

A new research paper by scientists at Janssen Vaccines & Prevention BV, in the Netherlands and published on the preprint server bioRxiv* is based on the assumption that an effective vaccine against these infections will induce neutralizing antibodies and an immune response favoring Th1 immunity.

3 Aug 2020

Engineered SARS-CoV-2 spike protein is more stable and can generate larger yields in the lab

A team of scientists has engineered the spike protein of the SARS-CoV-2 virus - a critical component of potential COVID-19 vaccines - to be more environmentally stable and generate larger yields in the lab.

23 Jul 2020

Researchers stabilize the closed SARS-CoV-2 spike trimer

Now, a new study by researchers at Janssen Vaccines & Prevention BV and Leiden University and published on the preprint server bioRxiv uses cryoEM to reveal the structure of this trimer, in order to support both vaccine development and diagnostic testing based on antibody production.

14 Jul 2020

Novavax SARS-CoV-2 vaccine candidate shows promise in animal models

A new study published on the preprint server bioRxiv in June 2020 shows that a candidate spike protein vaccine can induce neutralizing antibodies, antiviral T cell responses, and protection against infection.

2 Jul 2020

Striking CryoEM image of SARS-CoV-2

A new study by researchers from the UK and Germany and published on the preprint server bioRxiv in June 2020 reports the results of a detailed study of the S protein on the intact virus, using cryoelectron microscopy (cryoEM) and tomography. This could help understand the conformation of the S protein on the virion and how it interacts with neutralizing antibodies.

30 Jun 2020

Growth, adaptation and neutralization of SARS-CoV-2 with acute-phase serum

One recent study published on the preprint server bioRxiv in June 2020 reports the results of growing and characterizing the virus, as well as the development of neutralizing antibodies in the serum of acutely infected hospitalized patients with COVID-19.

22 Jun 2020

Brain-transportable soy derivate reduces memory degradation in mice

In a study that could help one day give a literal meaning to food for thought, researchers from Kyushu University in Japan have reported that a protein fragment that makes its way into the brain after being ingested can reduce memory degradation in mice treated to simulate Alzheimer's disease.

21 Jun 2020

How antibodies neutralize SARS-CoV-2 in convalescent patients

A new study by researchers from the United Kingdom and Taiwan and published on the preprint server bioRxiv in June 2020 describes the structural basis for the neutralizing effect of the SARS-CoV-2 antibody on the virus. This also indicates a possible therapeutic molecule by identifying its binding epitope as possibly a major neutralizing site.

16 Jun 2020

NIAID and Moderna scientists describe SARS-CoV-2 vaccine development

Researchers at the National Institute of Allergy and Infectious Diseases and Moderna Inc., have described the potent neutralizing effects of a candidate vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is currently being tested in a phase II trial.

14 Jun 2020

Unique mutations could weaken Indian SARS-CoV-2 strain

A new study published on the preprint server bioRxiv in June 2020 suggests that the presence of unique mutations in the viral strains circulating in India has led to their attenuation.

9 Jun 2020

KFU research group finds ways to disrupt protein synthesis in Staphylococcus aureus

It is well known that many strains of Staphylococcus are resistant to antibiotics, and research groups around the world seek new targets in the bacteria to decrease their infectious potential.

9 Jun 2020

SARS-CoV-2 genome variants in India

A new study published online on the preprint server bioRxiv in June 2020 surveys the genetic diversity of SARS-CoV-2 strains in India.

7 Jun 2020

Study reveals how essential SARS-CoV-2 protein can be stabilized and scaled for production

A research group from the University of Texas in Austin described a high-yield production of a stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S-protein) that may accelerate the development of vaccines and diagnostic tests. This methodological 'tour de force' paper is currently available on the bioRxiv* preprint server.

1 Jun 2020

Gut bacteria may predict risk of pulmonary hypertension

A team of researchers has found that the microflora of bacteria within the gut of humans could be a contributor to the development of pulmonary arterial hypertension (PAH). The study titled, "Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension," in the latest issue of the American Heart Association's journal Hypertension.

24 Feb 2020

Study finds cluster of factors that may help predict C. diff infections

A cluster of factors may help predict which patients are likely to develop Clostridioides difficile, a potentially life-threatening disease commonly known as C. difficile or C. diff, a new study has found.

25 Oct 2018