Protein Folding News and Research

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Mutation in a ribosomal protein leads to impaired cardiac contractility in mice

A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.

19 May 2023

The Power of Solid-State Nuclear Magnetic Resonance in Biological Research

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year's recipient of the Pittsburgh Spectroscopy Award, Robert Tycko.

From Pittcon 20 Apr 2023

SpatialOMx - Mass Spectrometry and the Future of Spatial Biology

In this interview, Bruker speaks with Ramon Sun on the topic of SpatialOMx - a field that is currently experiencing great changes. Dive in to discover how Bruker will rise to the challenge.

From Bruker Life Sciences Mass Spectrometry 17 Mar 2023

Brain development in autistic Individuals differs from people with typical neurodevelopment, study confirms

A new study led by UC Davis MIND Institute researchers confirms that brain development in people with autism differs from those with typical neurodevelopment.

3 Mar 2023

New insights into how amino acids shaped the genetic code of ancient microorganisms

By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today-;including plants, animals, and humans.

27 Feb 2023

Electrochemical method helps to continuously witness and analyze details of protein folding

Scientists are not yet clear on how the tau protein changes from a benign protein essential for normal function in our brains into the toxic neurofibrillary tangles that are a signature of Alzheimer's and other neurodegenerative diseases.

15 Feb 2023

Cryo-EM reveals the structure of hnRNPDL-2 protein fibrils associated with limb-girdle muscular dystrophy

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein.

3 Feb 2023

Study shows the modulatory effect of resistance training on the endoplasmic reticulum in older adults

Aging involves a balance between oxidants and antioxidants, low-grade inflammation and a protein response that occurs at the cellular level, which is responsible for many health disorders.

17 Jan 2023

Landmark study challenges a 70-year-old theory of protein folding

A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system.

9 Dec 2022

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Researchers investigated the change in the stability, antigenicity, and protein expression of the SARS-CoV-2 spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein.

14 Nov 2022

Transcriptomic dysregulation across cerebral cortex in autism spectrum disorder

A new study demonstrated transcriptomic dysregulation in the cerebral cortex in autism spectrum disorder (ASD).

7 Nov 2022

Scientists develop a pseudovirus system to deep mutational scan the full SARS-CoV-2 spike

A pseudovirus system based on deep mutational scanning determines how SARS-CoV-2 mutations can affect its ability to escape neutralization.

18 Oct 2022

Insights into molecular folding of AAT protein will help develop new therapies for alpha-1 antitrypsin deficiency

In a major new development in the quest to develop better gene therapies with which to treat a host of diseases, researchers at the University of Massachusetts Amherst and UMass Chan Medical School recently announced that they have mapped the expression and maturation of the protein alpha-1 antitrypsin (AAT) with unprecedented clarity.

25 Jul 2022

Unique tool helps to study how the mechanical forces behind protein folding affect cancer spread

Talin is a protein that controls cellular attachment and movement, but its malfunctioning also allows cancer cells to spread. DCL1 is a tumor-suppressing protein. But scientists don't fully understand how either protein works – or what happens when they don't work the way they should.

15 Jul 2022

Protein Folding News and Research

Mutation in a ribosomal protein leads to impaired cardiac contractility in mice

The Power of Solid-State Nuclear Magnetic Resonance in Biological Research

SpatialOMx - Mass Spectrometry and the Future of Spatial Biology

Brain development in autistic Individuals differs from people with typical neurodevelopment, study confirms

New insights into how amino acids shaped the genetic code of ancient microorganisms

Electrochemical method helps to continuously witness and analyze details of protein folding

Cryo-EM reveals the structure of hnRNPDL-2 protein fibrils associated with limb-girdle muscular dystrophy

Study shows the modulatory effect of resistance training on the endoplasmic reticulum in older adults

Landmark study challenges a 70-year-old theory of protein folding

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Transcriptomic dysregulation across cerebral cortex in autism spectrum disorder

Scientists develop a pseudovirus system to deep mutational scan the full SARS-CoV-2 spike

Insights into molecular folding of AAT protein will help develop new therapies for alpha-1 antitrypsin deficiency

Unique tool helps to study how the mechanical forces behind protein folding affect cancer spread

SARS-CoV-2 3CLpro also susceptible to mutations

Scientists create new fluorophores that could help fight cancer

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Newly-discovered mechanism may help prevent the build-up toxic proteins in dementia

ProteoGenix launches new XtenCHOTM Transient CHO Expression System to improve biologics development

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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