Protein Synthesis News and Research

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Anti-diarrhea drug triggers cell death in glioblastoma cells

In cell culture, loperamide, a drug commonly used against diarrhea, proves effective against glioblastoma cells. A research team at Goethe University has now unraveled the drug’s mechanisms of action of cell death induction and – in doing so – has shown how this compound could help attack brain tumors that otherwise are difficult to treat.

22 Dec 2020

Study highlights the far-reaching effects of mutagenic compounds on human health

In order to survive, flourish and successfully reproduce, organisms rely on a high degree of genetic stability. Mutagenic agents, which can threaten the integrity of the genetic code by causing mutations in DNA, pose a serious risk to human health.

21 Dec 2020

Short term “prehabilitation” strength exercises, undertaken pre-surgery, do not prevent muscle loss

Older adults about to undergo elective surgery should undertake a sustained programme of targeted exercise beforehand to counteract the muscle-wasting effects of bedrest, new research suggests.

21 Dec 2020

4E-BP proteins are key to unlock the antidepressant effect of ketamine in the brain

A group of proteins called 4E-BPs, involved in memory formation, is the key to unlocking the antidepressant effect of ketamine in the brain, according to researchers from three Canadian universities. The discovery could lead to better and safer treatments for certain patients suffering from major depression.

17 Dec 2020

Researchers study the mechanisms of skin aging

The ageing process is most apparent on the skin. In the newly opened "SKINMAGINE" (Multimodal Imaging of Aging and Senescence of the Skin) Christian Doppler Laboratory, dermatologists from MedUni Vienna have joined forces with biotechnologists from the University of Natural Resources and Applied Life Sciences Vienna and chemists from Vienna University of Technology, as well as the company Chanel, to study the interaction of metabolism, cellular communication and cellular quality control in skin ageing accelerated by environmental stress.

16 Dec 2020

Resistance training and peanut protein supplementation positively affect muscle health in older adults

Declines in muscle mass and strength can begin in early adulthood, unnoticeable at first, and eventually progress until functionality, endurance, and general health may be compromised.

15 Dec 2020

Study unlocks some muscle cell secrets

A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are.

11 Dec 2020

Research team develops a new decoding method for viral genes

Comprehensive identification of viral proteins encoded by viral genes is required to understand the pathophysiology of viral infections.

7 Dec 2020

CNRS develops new patented technique that reveals energy status of cells

A procedure that may help personalise anticancer therapies has just been developed by the CNRS, INSERM, and Aix-Marseille University scientists at the Centre d'Immunologie de Marseille-Luminy, in association with colleagues from the University of California San Francisco and the Marseille Public University Hospital System (AP-HM), with support from Canceropôle Provence-Alpes-Côte d'Azur.

2 Dec 2020

SARS-CoV-2 launches multipronged attack against host cell protein synthesis, study finds

An interesting new study throws a flood of light on how SARS-CoV-2 accomplishes its mission to infect and replicate within host cells while evading the host immune response.

27 Nov 2020

Ipom-F inhibits SARS-CoV-2 infection in vitro

An international team of researchers showed the small molecule inhibitor, ipomoeassin F (Ipom-F), blocks the translocation/insertion of the three protein targets for SARS-CoV-2 infection.

27 Nov 2020

Scientists address a bottleneck in the protein trafficking system

Proteins are the essential substrate of learning and memory. However, while memories can last a life-time, proteins are relatively short-lived molecules that need to be replenished every couple of days.

23 Nov 2020

Researchers investigate challenges of treating acute myocardial infarction caused by variant angina

In a new publication from Cardiovascular Innovations and Applications, Wen-Yuan Ding, Jia-Min Li, Fei Zheng, Li-Li Wang, Xin-Yi Wei and Guo-Hua Li from Shandong Provincial Qianfoshan Hospital, Ji'nan, China, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji'nan, China and Shandong First Medical University, Tai'an, China consider the challenges of treating acute myocardial infarction due to variant angina.

19 Nov 2020

Pioneering technique sheds new light on the origin of metastases

Research can now target metastases more effectively thanks to a new approach that takes into account the enormous heterogeneity and phenotypes of tumor cells, with a team from UNIGE pinpointing a gene that prevents their development.

10 Nov 2020

Translational study within SARS-CoV-2 infected cells opens up new therapeutic avenues

A recent study published on the preprint server bioRxiv in October 2020 shows what the protein translation process looks like in specific terms. In doing so, the study has provided new insights that might prove helpful in developing new therapies for COVID-19 patients.

9 Nov 2020

APS technique shows how SARS-CoV-2 virus camouflages itself inside the human body

Scientists using the Advanced Photon Source have discovered new insights into the ways the SARS-CoV-2 virus camouflages itself inside the human body.

30 Oct 2020

Research team discovers a new key player in long-term memory

A McGill-led multi-institutional research team has discovered that during memory consolidation, there are at least two distinct processes taking place in two different brain networks - the excitatory and inhibitory networks.

7 Oct 2020

New mechanism that prevents hair loss identified

A team of researchers from Cologne and Helsinki has discovered a mechanism that prevents hair loss: hair follicle stem cells, essential for hair to regrow, can prolong their life by switching their metabolic state in response to low oxygen concentration in the tissue.

28 Sep 2020

ALS and FTLD result from reduced transportation of messenger RNA

The lack of protein TDP-43 in two neurodegenerative diseases is shown to prevent neuron growth via failed transport of RNA and subsequent absence of protein synthesis in axons

23 Sep 2020

Research underlines SARS-CoV-2 N-terminal domain of Nsp1 as a potential drug target

A recent study reveals how the non-structural protein 1 (NSP1) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a crucial role in inhibiting the host cell protein synthesis but simultaneously facilitating the viral protein synthesis.

21 Sep 2020