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Autism in males may result from problems in brain-based immune cells

Many cases of autism spectrum disorders may result from problems in immune cells that normally work to trim back unneeded brain connections in early life, suggests a new study led by scientists at Scripps Research.

15 Apr 2020

World's largest protein connection map reveals cell workings

The human body is comprised of billions of cells. Yet it functions and grows as a single organism, because of trillions of interactions that help various cells recognize and respond to each other via different molecules on their surface or inside the cells. Now, a new study published in the journal Nature in April 2020 describes the first-ever interactome map, to help distinguish healthy interactions and disease-producing ones.

8 Apr 2020

Working too many hours may lead to an underactive thyroid

A new study has found that people who work longer hours are more likely to have an underactive thyroid or hypothyroidism.

31 Mar 2020

Research shows how stress restructures the brain

Stress restructures the brain by halting the production of crucial ion channel proteins, according to research in mice recently published in JNeurosci.

25 Mar 2020

Discovery shows a novel opportunity for DOT1L inhibitors in cancer treatment

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and discovered that genes belonging to the endoplasmic reticulum stress pathway and protein synthesis machinery were specifically suppressed in sensitive cells.

22 Mar 2020

CARB-X awards $2.86M to develop novel oral antibiotic to treat drug-resistant gonorrhea

Up to $2.86M has been awarded to a research team including Penn State scientists to develop a new oral antibiotic to treat multidrug-resistant gonorrhea, a sexually transmitted disease caused by bacteria that have developed resistance to all but one existing antibiotic.

20 Mar 2020

How to slow down age-related changes?

Healthy aging has become one of the priorities of research in Europe. University of Tartu researchers looked for differences in the immune systems of young and old people.

19 Mar 2020

Researchers establish a gene expression profile associated with cachexia in cancer patients

It is estimated that as many as 80% of advanced-stage cancer patients may develop cachexia, a potentially fatal metabolic syndrome characterized by extreme weight loss and muscle wasting, but scientists do not yet fully understand why it is more frequently associated with certain kinds of tumor than others, or why not all cancer patients develop it.

3 Mar 2020

Stress in kids could have long term genetic consequences finds study

Researchers have found that being separated from parents at a young age could lead to a rise in stress hormones, which could have direct consequences on altering the genetic makeup of the child, which can then be passed on to the future generations. The study titled, "Childcare outside the family for the under-threes: cause for concern?" was published in the latest issue of the Journal of the Royal Society of Medicine.

16 Feb 2020

Newly discovered large phages blur the life/non-life boundary

A new study published in the journal Nature shows that there are literally hundreds of viruses large enough to consume bacteria, and with properties that are typical of a living organism rather than the non-living self-replicating packages of DNA/RNA that viruses are often assumed to be.

12 Feb 2020

Study explores how some mammals postpone development of their embryos

How do some mammals postpone the development of their embryos to await better conditions for having offspring? A recent study at the UW Medicine Institute for Stem Cell and Regenerative Medicine explored this reproductive enigma, which can occur in more than 130 species of mammals as well as in some marsupials.

10 Feb 2020

Turning stink into therapy for atherosclerosis

In an amusing but amazing turnaround, it seems the most foul-smelling compound on earth, called putrescine, could help relieve chronic inflammation, most importantly in the arterial thickening called atherosclerosis. This discovery is reported in the journal Cell Metabolism in January 2020.

30 Jan 2020

New genetic screen for Huntington’s disease

Huntington’s disease is a genetic disease that is debilitating and progressive leading to severe brain damage and eventual death. In patients with this autosomal dominant disease, there is presence of a protein called the Huntingtin protein that forms clumps within the brain leading to the symptoms of the disease.

30 Jan 2020

Link between autism and poor cognition

Autistic people are often brilliant, but they may also have poor cognitive skills. The relationship between autism and either condition, inside the brain, has been far from clear. However, now a new study shows that poor cognition in autism could be due to the influence of a small gene fragment.

29 Jan 2020

New molecular probe senses the state of proteome in live cells

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment.

10 Jan 2020

SVC112 molecule acts specifically against head and neck cancer stem cells

The red, tube-shaped flowers of the firecracker bush (Bouvardia ternifolia), native to Mexico and the American Southwest, attract hummingbirds.

8 Jan 2020

Goethe University researchers develop new method to measure acute cellular changes

When cells are stressed, they initiate a complex and precisely regulated response to prevent permanent damage. One of the immediate reactions to stress signals is a reduction of protein synthesis (translation). Until now, it was difficult to measure such acute cellular changes. As reported in the latest online issue of the renowned journal Molecular Cell, researchers at Goethe University have now developed a method overcoming this hurdle.

5 Dec 2019

New compound may enhance dengue vaccine efficacy by simulating amino acid deficiency

A new study published in the journal Science Signaling on November 26, 2019, describes a mouse experiment, in which the immune response to the dengue vaccine was boosted when the mice were first given halofuginone, a plant compound that is well known to herbalists.

27 Nov 2019

Study points to two types of motion that keeps cells in shape

The health of cells is maintained, in part, by two types of movement of their nucleoli, a team of scientists has found. This dual motion within surrounding fluid, it reports, adds to our understanding of what contributes to healthy cellular function and points to how its disruption could affect human health.

26 Nov 2019

Researchers uncover novel pathogenic mechanism in Huntington’s disease

Researchers from the Institute of Neurosciences of the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute described a mechanism, the increase of proteinaceous synthesis, which takes part in the degeneration of the type of neurons that are affected in Huntington's disease, a genetic neurodegenerative disease.

20 Nov 2019