Proteome News and Research

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The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

Microscopy-based high content platform for SARS-CoV-2 serological screening

A new study published on the medRxiv* preprint server used automated high content immunofluorescence microscopy (AHCIM) to assess the viability of such an approach to detect humoral immune responses against SARS-CoV-2 proteins.

20 Oct 2021

Mapping proteo-genomic connections between different human diseases

Hundreds of connections between different human diseases have been uncovered through their shared origin in our genome by an international research team led by scientists from the Medical Research Council Epidemiology Unit at the University of Cambridge, challenging the categorization of diseases by organ, symptoms, or clinical specialty.

15 Oct 2021

Research reveals components of Sinbis virus ribonucleoproteins

To address this gap in research regarding the understanding of post-replicative alphavirus RNPs, scientists have created a novel proteome-wide approach known as viral RNA interactome capture (vRIC). This study is available in the bioRxiv* preprint server while awaiting peer review.

11 Oct 2021

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Recently, scientists have developed a bacterial two-hybrid (B2H) system to study the PPIs of SARS-CoV-2 in a heterologous non-eukaryotic system. This study is available on the bioRxiv* preprint server. Put simply, the B2H system could be used to analyze the SARS-CoV-2 proteome.

11 Oct 2021

SARS-CoV-2 viroporin activity impacts viral infectivity and pathogenicity

A team of researchers studied the two main viroporins of SARS-CoV-2, namely Orf3a and Envelope (E) protein, from a structural viewpoint.

29 Sep 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

This 3D modeling reveals how SARS-CoV-2 attacks

Now, researchers at the Garvan Institute of Medical Research, Darlinghurst in Australia, CSIRO Data61, and the School of Biotechnology and Biomolecular Sciences (UNSW) demonstrated the most comprehensive analysis of the three-dimensional structure of SARS-CoV-2, providing a new insight into how the virus infects cells and replicates.

16 Sep 2021

Delta variant has a more diverse repertoire of mutations than other variants

In a paper, nearly 2 million SARS-CoV-2 genomes from around the world were analyzed, finding great diversity within the delta variant that exceeds that observed in the more widely spread alpha variant.

6 Sep 2021

Computational study identifies human proteins structurally similar to SARS-CoV-2 proteins

A new study published in Scientific Reports identifies the human proteins that share structural similarities with the SARS-CoV-2 proteins.

30 Aug 2021

COVIDome Explorer online portal launched to accelerate COVID-19 research on a global scale

To further accelerate COVID-19 research on a global scale, investigators from the University of Colorado Anschutz Medical Campus have created a multidimensional dataset, known as the COVIDome dataset, derived from hospitalized COVID-19 patients versus negative controls.

17 Aug 2021

Scientists develop new approach to identify proteins in the living brain

For the first time, researchers have developed a successful approach for identifying proteins inside different types of neurons in the brain of a living animal.

11 Aug 2021

Study shows efficacy of gamma irradiation of SARS-CoV-2 vaccine candidate in mouse model

A new study reports a more rapid method of viral inactivation in an effort to increase the appeal of inactivated viral vaccines against the COVID-19 pandemic.

10 Aug 2021

Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

In a recently published article in The New England Journal of Medicine, scientists have described how multi-mutational variants of SARS-CoV-2 may evolve in patients with immunosuppression.

5 Aug 2021

PROTEIN-ID project aims to develop a device able to generate identity card of proteins

A device able to generate proteins identity card: this is the ambitious goal of the "PROTEIN ID" project, funded by the European Union with about 3 million euro for the next 3 years and coordinated by the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology).

3 Aug 2021

Pfizer moves towards an oral anti-COVID-19 therapy

Researchers in the United States have described a novel antiviral agent against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently being evaluated in clinical trials as a treatment for coronavirus disease 2019 (COVID-19).

2 Aug 2021

CD8+ T cells show gene-dependent variation in cross-reactivity to human coronaviruses

A new study discusses how both different responses to the infection itself and to COVID-19 vaccines are likely the result of genetic differences.

25 Jul 2021

Researchers identify an unexpected effect for already characterized active substances

Every innovative drug starts with the search for an active substance targeting key players in disease-related processes.

23 Jul 2021

Finding most promising targets for pan-coronavirus drugs

Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever.

22 Jul 2021

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

The study, published in the journal Angewandte Chemie International Edition, identified many small molecules that bind to certain parts of the SARS-CoV-2 genome that are less likely altered by mutations using dedicated substance libraries. The scientists derived key functional units and groups in ligands for effective and safe targeting of SARS-CoV-2 RNA.