The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.
Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases.
PhoreMost will deploy its in-house expertise and next-generation phenotypic screening platform, SITESEEKER, in disease-relevant pathways nominated by Otsuka.
Australia needs a new whooping cough vaccine to ensure our most vulnerable are protected from the emergence of superbug strains, new UNSW research has shown.
Some plastic food and beverage containers still contain bisphenol A, which can mimic the hormone estrogen. Although experts say that small amounts of BPA detected in foods are unlikely to cause problems, some people worry that constant low-level exposures could have health effects, especially for developing fetuses, infants and children.
The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment.
PhoreMost to deploy its SITESEEKER platform to identify novel targets for Boehringer Ingelheim’s discovery programs.
Grizzly bears spend many months in hibernation, but their muscles do not suffer from the lack of movement. In the journal "Scientific Reports", a team led by Michael Gotthardt reports on how they manage to do this.
Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases.
Every cell contains a vast number of proteins, each of which has a specific function, for example as a receptor for another molecule or an enzyme that catalyzes chemical reactions.
Australian researchers are making major inroads into finding the cause of heart disease, Alzheimer's, cancer, diabetes and other diseases after discovering a further 148 proteins affected by oxidative stress in the human body.
Looking to gain a deeper understanding of cancer, a team led by researchers at Baylor College of Medicine conducted an extensive computational analysis of the similarities and differences in the entire set of proteins, called the proteome, of more than 500 cancers from five different tissue sites.
Normally, bird flu viruses do not spread easily from person to person. But if this does happen, it could trigger a pandemic. Researchers from the MDC and RKI have now explained in the journal Nature Communications what makes the leap from animals to humans less likely.
Proteins in our blood could in future help provide a comprehensive 'liquid health check', assessing our health and predicting the likelihood that we will we will develop a range of diseases, according to research published today in Nature Medicine.
Measuring proteins in the blood could serve as a “liquid health check” that could predict people’s risk of developing diseases.
Arrayjet, the Scottish-based microarray instrumentation company, has secured a GBP250,000 contract to provide the Swedish SciLifeLab - the national hub for molecular bioscience in Sweden - with microarray technology to provide further analytical information for mapping the human protein atlas.
Matthias Mann explains why applying proteomics-based technologies such as timsTOF could accelerate the diagnosis and prediction of human disease.
News-Medical Life Sciences spoke to Nicholas Dupuis from Biognosys at Neuroscience 2019 about proteomics & DIA mass spectrometry in neurodegenerative disease research.
Researchers at the University of Liverpool have made a major breakthrough in the field of cell signalling.
There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are exploited by therapeutic drugs. In fact, one in three drugs makes use of receptors belonging to a single very large family – the GPCR (G protein receptor coupled receptor) family.
The study, published recently in Molecular Biology and Evolution, describes the discovery that human saliva is much more watery than the saliva of chimpanzees and gorillas.