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The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

Epigenetic insights into stroke-induced immunological changes

A stroke not only causes acute damage to the brain, but can also have long-term health implications for other organs - such as the heart.

23 Jul 2024

Discovery of over 1,000 undetected proteins in metabolite samples

Van Andel Institute scientists have identified more than 1,000 previously undetected proteins in common metabolite samples, which persist despite extraction methods designed to weed them out.

18 Jul 2024

New signaling pathway identified in aural migraine headaches

The rapid influx of cerebral spinal fluid (CSF) and protein solutes released during cortical spreading depression (CSD) in the brain activates neurons to trigger aural migraine headaches, according to a new mouse study.

4 Jul 2024

Early detection of aggressive multiple myeloma through molecular analysis

Multiple myeloma is one of the most common forms of cancer of the immune cells in the bone marrow. It is considered incurable.

1 Jul 2024

Artificial variants of Withanolides act highly specifically against leukemia cells

Nightshade plants produce a diverse array of compounds with therapeutic potential. Researchers at CeMM have now identified an artificial variant inspired by the Withanolides group that acts highly specifically against leukemia cells.

21 Jun 2024

Study reveals cognitive benefits of ketogenic diet in aged mice

The impact of cyclic ketogenic diet treatments in improving the age-related decline in brain function.

20 Jun 2024

How ketone bodies contribute to brain health and memory preservation

The ketogenic diet has its fanatics and detractors among dieters, but either way, the diet has a scientifically documented impact on memory in mice.

17 Jun 2024

Deep learning revives ancient peptides to battle antibiotic resistance

Researchers used deep learning to resurrect antibiotic peptides from extinct organisms, offering new solutions for combating antibiotic resistance.

12 Jun 2024

UD researchers pioneer universal, economical method for proteomics sample preparation

Proteins are workhorses that carry out most of the biological functions in our cells. While the genes we inherit from our parents, our so-called genome, are fixed and usually remain unchanged throughout our lives, proteins in our bodies are constantly changing, as we age, under different health conditions and upon stimulation, such as with medical treatment.

11 Jun 2024

Young bone marrow transplants show promise in reversing Alzheimer's symptoms in mice

Researchers found that young bone marrow transplants rejuvenate aging immune cells, reducing Alzheimer's symptoms in mice models, suggesting a potential therapeutic approach for the disease.

4 Jun 2024

New study identifies key protein biomarkers for early detection of pancreatic cancer

Study used a Mendelian randomization approach to identify REG1A and REG1B as potential biomarkers for early detection of pancreatic cancer, showing their causal effects and significance in cancer screening.

19 May 2024

Boosting mitochondrial health can reverse protein clumping in aging and Alzheimer's

It has long been known that a hallmark of Alzheimer's disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain.

16 May 2024

Study reveals altered protein rhythms linked to metabolic disorders in night shift workers

Just a few days on a night shift schedule throws off protein rhythms related to blood glucose regulation, energy metabolism and inflammation, processes that can influence the development of chronic metabolic conditions.

9 May 2024

Researchers identify novel biomarkers in renal cell carcinomas

A new study led by University of Michigan Health Rogel Cancer Center researchers identifies novel biomarkers in renal cell carcinomas.

6 May 2024

Researchers identify key molecular alterations from endurance exercise that could combat chronic diseases

A whole-organism molecular map of the temporal effects of endurance training in rats.

3 May 2024

Protein profiling reveals impact of aging and resistance training on skeletal muscle proteome

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training."

2 May 2024

New drug candidate reverses obesity in mice by transforming liver metabolism

A mitochondrial transcription inhibitor (IMT) shifted metabolism in high-fat diet mice toward fatty acid oxidation, leading to weight loss, reduced liver fat, and improved glucose tolerance.

1 May 2024

Scientists map all yeast proteins across cell cycle for the first time

An international team led by researchers at the University of Toronto has mapped the movement of proteins encoded by the yeast genome throughout its cell cycle. This is the first time that all the proteins of an organism have been tracked across the cell cycle, which required a combination of deep learning and high-throughput microscopy.

23 Apr 2024

New trials show promise for immune checkpoint blockers in early-stage lung cancer

A dendritic cell (DC) vaccine targeting patient-specific neoantigens to patients with resected non-small cell lung cancer (NSCLC).

18 Apr 2024

Blood protein could be a potential biomarker for delayed concussion recovery in children

Researchers have discovered a blood protein that could help detect which children will experience ongoing concussion symptoms more than two weeks after an injury.

9 Apr 2024