The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.
AlphaMissense, an adaptation of AlphaFold, offers a highly accurate model for predicting the pathogenicity of human proteome-wide missense variants at the single amino acid level. The model outperforms existing methods, providing valuable insights for diagnosing rare diseases and developing targeted therapies.
DeepMind is releasing AlphaMissense, a tool researchers can use to learn more about the effects that missense mutations – which make up the majority of "variants of uncertain significance" – have on disease.
Researchers demonstrated a MRI method sensitive to the live brain's iron homeostasis (the r1-r2 extent of relaxation or relaxivity).
Researchers designed and evaluated a multi-epitope vaccine targeting the main outer membrane protein of Chlamydia pneumoniae using immunoinformatics.
The sequencing of the human genome promised a revolution in medicine, but scientists soon realized that a genetic blueprint alone does not show the body in action.
Researchers investigated the impact of biological sex on protein levels and its genomic control by analyzing 1,277 proteomes of the brain.
Researchers found that short-term intensive fasting enhances the immune function of red blood cells, including their ability to combat SARS-CoV-2, without affecting their oxygen-carrying capacity. The study reveals that this fasting regimen popular in Asia could offer a multifaceted benefit by amplifying the body's defenses without compromising essential functions.
In this interview, News-Medical had the opportunity to speak with Dr. Xiaobing Han, Principal Scientist for Antibody Discovery at Rapid Novor.
Researchers investigated the relationship between diet and the proteome.
The impacts of physical activity on the neuronal formation and prevent age-related cognitive decay.
The genetic architecture of circulating retinol.
The application of proteomics-driven biomarkers for early detection, diagnosis, and treatment of pancreatic cancer.
Researchers investigate the association between the circulating proteome and brain health.
Researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral sclerosis (ALS).
Alzheimer's is considered a disease of old age, with most people being diagnosed after 65. But the condition actually begins developing out of sight many years before any symptoms emerge.
Researchers conducted cerebrospinal fluid (CSF) proteome profiling and identified CSF proteins.
In this interview, News-Medical talks to Sylvia Xie, product scientist at Sino Biological, about the ongoing emergence of transmembrane proteins as targets for therapeutic antibodies.
Recently published in The Journal of Translational Medicine, a team at Lawson Health Research Institute has discovered unique patterns of blood plasma proteins in patients with long COVID that could reveal potential drug targets to improve patient outcomes.
The genetic plans within our DNA come to functional fruition through proteins, which underlie our bodies' structure and activity.
Research focuses on the design of a multi-epitope polyvalent vaccine against Human Respiratory Syncytial Virus (RSV), a leading cause of lower respiratory tract infections. The study utilizes computational methods and immunoinformatics tools to predict potential vaccine candidates and their interactions with Toll-like receptors (TLRs).