Proteome News and Research

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The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

New technology systematically identifies drug targets in living animals

Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases.

21 Jan 2020

SITESEEKER to be used for Otsuka’s therapeutics discovery programs

PhoreMost will deploy its in-house expertise and next-generation phenotypic screening platform, SITESEEKER, in disease-relevant pathways nominated by Otsuka.

From PhoreMost 21 Jan 2020

New whooping cough vaccine needed to protect from emerging superbug strains

Australia needs a new whooping cough vaccine to ensure our most vulnerable are protected from the emergence of superbug strains, new UNSW research has shown.

16 Jan 2020

BPA activates immune response in mice that persists for at least three generations

Some plastic food and beverage containers still contain bisphenol A, which can mimic the hormone estrogen. Although experts say that small amounts of BPA detected in foods are unlikely to cause problems, some people worry that constant low-level exposures could have health effects, especially for developing fetuses, infants and children.

16 Jan 2020

New molecular probe senses the state of proteome in live cells

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment.

10 Jan 2020

Boehringer Ingelheim to use PhoreMost's SITESEEKER platform in new collaboration

PhoreMost to deploy its SITESEEKER platform to identify novel targets for Boehringer Ingelheim’s discovery programs.

From PhoreMost 7 Jan 2020

Grizzly bears' strategy could help prevent muscle atrophy in humans

Grizzly bears spend many months in hibernation, but their muscles do not suffer from the lack of movement. In the journal "Scientific Reports", a team led by Michael Gotthardt reports on how they manage to do this.

30 Dec 2019

Researchers identify novel genetic signature with prognostic value for certain breast cancers

Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases.

17 Dec 2019

New tool gives more reliable and precise results in cancer research

Every cell contains a vast number of proteins, each of which has a specific function, for example as a receptor for another molecule or an enzyme that catalyzes chemical reactions.

16 Dec 2019

Researchers making major inroads into finding the cause of different diseases

Australian researchers are making major inroads into finding the cause of heart disease, Alzheimer's, cancer, diabetes and other diseases after discovering a further 148 proteins affected by oxidative stress in the human body.

12 Dec 2019

Extensive tumor protein analysis reveals potential new players in cancer

Looking to gain a deeper understanding of cancer, a team led by researchers at Baylor College of Medicine conducted an extensive computational analysis of the similarities and differences in the entire set of proteins, called the proteome, of more than 500 cancers from five different tissue sites.

12 Dec 2019

Researchers find another piece of puzzle relating to bird flu viruses

Normally, bird flu viruses do not spread easily from person to person. But if this does happen, it could trigger a pandemic. Researchers from the MDC and RKI have now explained in the journal Nature Communications what makes the leap from animals to humans less likely.

10 Dec 2019

Blood proteins could help provide a comprehensive 'liquid health check' in future

Proteins in our blood could in future help provide a comprehensive 'liquid health check', assessing our health and predicting the likelihood that we will we will develop a range of diseases, according to research published today in Nature Medicine.

2 Dec 2019

“Liquid health check” could predict disease risk in the future

Measuring proteins in the blood could serve as a “liquid health check” that could predict people’s risk of developing diseases.

2 Dec 2019

Arrayjet secures new contract to provide SciLifeLab with microarray technology for proteomics research

Arrayjet, the Scottish-based microarray instrumentation company, has secured a GBP250,000 contract to provide the Swedish SciLifeLab - the national hub for molecular bioscience in Sweden - with microarray technology to provide further analytical information for mapping the human protein atlas.

29 Nov 2019

Applying a Proteomics-based Approach to the Clinic

Matthias Mann explains why applying proteomics-based technologies such as timsTOF could accelerate the diagnosis and prediction of human disease.

From Bruker Daltonics 20 Nov 2019

Proteomics & DIA Mass Spectrometry in Neurodegenerative Disease Research

News-Medical Life Sciences spoke to Nicholas Dupuis from Biognosys at Neuroscience 2019 about proteomics & DIA mass spectrometry in neurodegenerative disease research.

From Biognosys AG 19 Nov 2019

Researchers make major breakthrough in cell signalling

Researchers at the University of Liverpool have made a major breakthrough in the field of cell signalling.

4 Nov 2019

Discovery of human cell signaling systems using bioinformatics

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are exploited by therapeutic drugs. In fact, one in three drugs makes use of receptors belonging to a single very large family – the GPCR (G protein receptor coupled receptor) family.

1 Nov 2019

Varied diets may be the cause for differences in human and non-human primate saliva

The study, published recently in Molecular Biology and Evolution, describes the discovery that human saliva is much more watery than the saliva of chimpanzees and gorillas.

31 Oct 2019