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The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

New studies on molecular and cellular proteomics

Researchers at the Karolinska Institute were using a proteomic screen to determine the mechanism by which cancer drug candidates killed cells when they realized a potential flaw in the standard experimental design.

21 Jun 2018

Researchers use advanced technology to identify proteomes of Th17 and iTreg cells

T helper 17 (Th17) cells belong to a group of T cells with essential functions in autoimmune diseases and inflammation. Regulatory T cells (iTregs) are T cells with a suppressive function to maintain self-tolerance and prevent autoimmune responses.

20 Jun 2018

Study provides insights into how components of different cells in the brain are altered

Scientists have revealed that protein molecules in the brain are broken down and replaced at different rates, depending on where in the brain they are.

20 Jun 2018

Staying up all night, sleeping all day can swiftly impact over 100 proteins in the blood

Staying awake all night and sleeping all day for just a few days can disrupt levels and time of day patterns of more than 100 proteins in the blood, including those that influence blood sugar, energy metabolism, and immune function, according to new University of Colorado Boulder research published in the journal PNAS this week.

22 May 2018

Study provides insights into how immune cells kill bacteria with acid

The first line of immune defense against invading pathogens like bacteria are macrophages, immune cells that engulf every foreign object that crosses their way. After enclosing it in intracellular membrane vesicles, a process called phagocytosis, macrophages kill their prey with acid.

17 May 2018

Study validates Xpresys Lung 2 for differential diagnosis of early stage lung cancer

Integrated Diagnostics today announced the e-publication of full results of a large prospective clinical trial validating its Xpresys Lung 2 in the peer-reviewed medical journal CHEST¸ the official journal of the American College of Chest Physicians, titled: Assessment of Plasma Proteomics Biomarker’s Ability to Distinguish Benign From Malignant Lung Nodules: Results of the PANOPTIC trial.

12 Mar 2018

USC scientists use metal-detection technique to study cancer

Metal detection has helped mining companies strike gold and airport security identify passengers who are a potential threat. Now USC scientists have pushed its use into another realm: studying cancer.

28 Feb 2018

Study reveals how carbohydrate-restricted diet improves metabolism

New details about how a carbohydrate-restricted diet improves metabolism were revealed in a study published today, which could lead to improved treatments for non-alcoholic fatty liver disease.

15 Feb 2018

Signaling molecules likely involved in concussions, rodent studies show

Traumatic brain injuries, whether suffered from a blow on the football field or the battle field, can be devastating, leading to disability and shortened lives.

18 Jan 2018

Key synaptic proteins could be targets for early interventions in patients with dementias

One of the most intriguing properties of the brain is its means to undergo synaptic plasticity which represents the basis for learning and memory, abilities that severely decline in the case of a dementia.

9 Jan 2018

Why Should We Weigh Every Protein in the Human Body?

Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level.

From Pittcon 5 Jan 2018

Researchers optimize method to increase resolution of proteomic analysis

One of the key challenges of proteomics, the study of all proteins expressed by a cell or organism, is managing to distinguish between molecules that are structurally different yet have the same mass.

4 Jan 2018

Researchers map first-ever proteome of healthy human heart

A healthy heart beats about two billion times during a lifetime – thanks to the interplay of more than 10,000 proteins. Researchers from the Max Planck Institute of Biochemistry and the German Heart Centre at the Technical University of Munich have now determined which and how many individual proteins are present in each type of cell that occurs in the heart.

17 Nov 2017

Using AFM to study cancer cells

I run a core facility for AFM techniques, biological medical applications. My research is focussed on in the interaction of platelets and cancer cells.

From Bruker Nano Surfaces 14 Nov 2017

Researchers evaluate impact of dried cranberries on gut health

Researchers from the University of Wisconsin - Madison evaluated whether one simple addition to the diet - one handful-a-day of sweetened dried cranberries - could positively influence the gut microbiome.

24 Oct 2017

New model predicts how E. coli bacteria respond to temperature changes, genetic mutations

Researchers at the University of California San Diego have developed a genome-scale model that can accurately predict how E. coli bacteria respond to temperature changes and genetic mutations.

13 Oct 2017

Study unveils neuronal effects of psychedelics using cerebral organoids

A Brazilian study, published in Scientific Reports on October 09, 2017, has identified changes in signaling pathways associated with neural plasticity, inflammation and neurodegeneration triggered by a compound from the family of dimethyltryptamine known as 5-MeO-DMT.

9 Oct 2017

Novartis partners with UC Berkeley to pursue 'undruggable' disease targets

Novartis has joined forces with researchers from the University of California, Berkeley, to develop new technologies for the discovery of next-generation therapeutics, pursuing the vast number of disease targets in cancer and other illnesses that have eluded traditional small-molecule compounds and are considered "undruggable."

28 Sep 2017

Metabolic changes after quitting could help explain how ill-effects of smoking may be reversible

Even after years of smoking, the body has a remarkable ability to repair itself. Now in a study appearing in ACS' Journal of Proteome Research, scientists report that certain metabolic changes occur soon after quitting, and these changes could help explain how some ill-effects of smoking might be reversible.

21 Sep 2017

Leading experts come together to discuss clinical, translational applications of mitochondria

The American Physiological Society will host the "Physiological Bioenergetics: Mitochondria from Bench to Bedside" conference August 27–30 in San Diego. The meeting will bring together cross-disciplinary experts who study the mitochondria, which provide the energy to individual cells.

23 Aug 2017