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The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

Using urine samples to diagnose disease in preterm newborns

The majority of patients in neonatal intensive care units are premature babies, who often have infectious (congenital pneumonia) or noninfectious (tachypnea, infant respiratory distress syndrome) respiratory pathologies.

9 Nov 2016

WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer

Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer.

25 Oct 2016

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers at St. Jude Children's Research Hospital have discovered the way toxic proteins linked to the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) incapacitate membrane-less organelles inside cells.

21 Oct 2016

Experts develop urine-based method to diagnose conditions in newborn babies

Experts from the V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology and the Moscow Institute of Physics and Technology have devised a method that uses the urinary proteome to diagnose conditions in newborn babies.

9 Sep 2016

MIT researchers develop novel method for multiscale imaging of the brain tissue

MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to peer at molecules within cells or take a wider view of the long-range connections between neurons.

27 Jul 2016

New bioinformatics tool can analyse 40,000 proteins per minute

Biology and computing have joined forces to create a piece of software that analyses mutations in proteins; these mutations are potential inducers of diseases, such as cancer.

30 Jun 2016

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

“IDPs” is now a widely used acronym that stands for “intrinsically disordered proteins.” It is the term generally used by the scientific community to refer to a wide variety of proteins that do not have a stable 3D structure and are instead characterized by a high extent of local mobility, disorder and many conformers that are accessible at room temperature.

From Bruker BioSpin - NMR, EPR and Imaging 30 Jun 2016

Study focuses on critical proteins involved in ovarian cancer biology

In what is believed to be the largest study of its kind, scientists at the Pacific Northwest National Laboratory, Johns Hopkins University and their collaborators from institutions across the nation have examined the collections of proteins in the tumors of 169 ovarian cancer patients to identify critical proteins present in their tumors.

30 Jun 2016

Scientists reveal metabolic reasons why low calorie diets may lead to longer life

Overeating can lead to health issues that can shorten one's life, such as obesity, diabetes and heart disease.

30 Jun 2016

New protein risk score may help predict cardiovascular risk in patients with CHD

In a study appearing in the June 21 issue of JAMA, Peter Ganz, M.D., of the University of California-San Francisco, and colleagues conducted a study to develop and validate a score to predict risk of cardiovascular outcomes among patients with coronary heart disease using analysis of circulating proteins.

21 Jun 2016

New blood test could help predict severity of pulmonary arterial hypertension

Johns Hopkins Medicine researchers report that rising blood levels of a protein called hematoma derived growth factor (HDGF) are linked to the increasing severity of pulmonary arterial hypertension, a form of damaging high blood pressure in the lungs.

20 Jun 2016

Simple blood test could help diagnose endometriosis

Endometriosis is a chronic, often painful disease affecting up to 10 percent of women of reproductive age in the U.S. How it develops is not well understood, and detecting it with certainty requires surgery.

16 Jun 2016

TSRI scientists develop novel technique for finding drug candidates

Scientists at The Scripps Research Institute have developed a powerful new method for finding drug candidates that bind to specific proteins.

16 Jun 2016

Scientists develop new tool to overcome major hurdle for personalized medicine

Scientists from EPFL and ETHZ have developed a powerful tool for exploring and determining the inherent biological differences between individuals, which overcomes a major hurdle for personalized medicine.

13 Jun 2016

Tackling healthcare challenges in a changing world: an interview with Professor Jeremy Nicholson

As individuals and as populations our risks of getting diseases are determined partly genetically and partly from the environment that we live in. An important part of that environment that mediates between the outside world and the inside world of our bodies is the microbiome.

10 Jun 2016

Scientists discover unexpected functions of snoRNAs that explains cause of some diseases

Scientists have discovered unexpected functions of small nucleolar RNAs (snoRNAs) that explain the cause of some diseases.

7 Jun 2016

First large-scale proteogenomic study helps pinpoint genes that drive breast cancer

Building on data from The Cancer Genome Atlas project, a multi-institutional team of scientists has completed the first large-scale "proteogenomic" study of breast cancer, linking DNA mutations to protein signaling and helping pinpoint the genes that drive cancer.

26 May 2016

Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Glyphosate, often sold under the brand name of Roundup, is the world's most widely used weed-killer. While Glyphosate has approval from regulatory bodies worldwide, there are growing concerns about its possible adverse health effects.

20 May 2016

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations.

16 May 2016

Saliva fingerprints could be useful in searching for signs of disease

Testing for health conditions usually involves needles, X-rays and other invasive or uncomfortable measures. To make diagnostics less burdensome for patients, scientists are developing alternatives, looking for disease markers in urine -- and even spit.

5 May 2016

Proteome News and Research

Using urine samples to diagnose disease in preterm newborns

WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Experts develop urine-based method to diagnose conditions in newborn babies

MIT researchers develop novel method for multiscale imaging of the brain tissue

New bioinformatics tool can analyse 40,000 proteins per minute

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

Study focuses on critical proteins involved in ovarian cancer biology

Scientists reveal metabolic reasons why low calorie diets may lead to longer life

New protein risk score may help predict cardiovascular risk in patients with CHD

New blood test could help predict severity of pulmonary arterial hypertension

Simple blood test could help diagnose endometriosis

TSRI scientists develop novel technique for finding drug candidates

Scientists develop new tool to overcome major hurdle for personalized medicine

Tackling healthcare challenges in a changing world: an interview with Professor Jeremy Nicholson

Scientists discover unexpected functions of snoRNAs that explains cause of some diseases

First large-scale proteogenomic study helps pinpoint genes that drive breast cancer

Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Unlocking the dark proteome: an interview with Dr Kriwacki

Saliva fingerprints could be useful in searching for signs of disease

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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