Rapamycin News and Research

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Rapamycin is a drug used to prevent the rejection of organ and bone marrow transplants by the body. Rapamycin is an antibiotic that blocks a protein involved in cell division and inhibits the growth and function of certain T cells of the immune system involved in the body's rejection of foreign tissues and organs. It is a type of immunosuppressant and a type of serine/threonine kinase inhibitor. Rapamycin is now called sirolimus.

Common diabetes drug controls aspects of inflammation in mice

The diabetes drug metformin--derived from a lilac plant that's been used medicinally for more than a thousand years--has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 diabetes.

9 Sep 2020

Study provides new insights into the host cellular response to SARS-CoV-2 infection

The COVID-19 pandemic caused by the new coronavirus has created an unprecedented public health challenge globally. Little was known about how the infecting cells respond to the virus and how the virus hijacks the host cellular machinery.

27 Jul 2020

People with accelerated biological age at increased risk of COVID-19 symptom severity and mortality

Now, a new study published on the preprint server medRxiv in July 2020 discusses the explanation in terms of the biological aging markers in patients with severe disease, rather than the chronological age.

13 Jul 2020

Clemson researcher receives DOD grant to explore cellular underpinnings of developmental disorder

College of Science associate professor and researcher David Feliciano has received a $667,000 grant from the Department of Defense to explore the cellular underpinnings of Tuberous Sclerosis Complex (TSC), a developmental disorder characterized by the growth of benign tumors throughout the body, most notably in the brain.

6 Jul 2020

Researchers discover key signaling pathway in the pathogenesis of Paget's disease

Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of poorly understood malignant skin cancers collectively known as Paget's disease.

26 Jun 2020

Cell signaling pathway may offer new drugs for tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a neurological disorder causing non-cancerous tumors, called cortical tubers, to grow throughout the brain and body, as well as other conditions like epilepsy and autism.

24 Jun 2020

Researchers use human stem cell models to analyze degeneration in glaucoma

More than 3 million Americans have glaucoma, a serious eye condition causing vision loss. Using human stem cell models, researchers at Indiana University School of Medicine found they could analyze deficits within cells damaged by glaucoma, with the potential to use this information to develop new strategies to slow the disease process.

11 Jun 2020

Researchers discover important molecular mechanism of Charcot-Marie-Tooth disease

Charcot-Marie-Tooth (CMT) disease is the most common form of inherited neuropathies. A genetic mutation causes the insulating myelin layer of peripheral nerves to become progressively damaged, resulting in severe disabilities in the case of CMT type 4B, for instance.

8 Jun 2020

Immune-regulating drug reverses dental problems in aging mice

A drug that has life-extending effects on mice also reverses age-related dental problems in the animals, according to a new study published today in eLife.

28 Apr 2020

Scientist proposes geroprotective strategies to reduce lethality of COVID-19 in the elderly

The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publication of a paper titled "Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections" in the leading journal Aging.

6 Apr 2020

Insights into diagnosis and treatment of rare pediatric brain cancer

Ependymoma is a rare form of brain cancer that implicates children and is often tricky to diagnose.

26 Mar 2020

Rapamycin worsens diseases and premature aging in mice with short telomeres

In the past few decades, it was discovered that the rate at which we age is strongly influenced by biochemical processes that, at least in animal models, can be controlled in the laboratory.

3 Mar 2020

Michael Hall named winner of 2020 Sjöberg Prize

Michael N. Hall, Ph.D., the National Foundation for Cancer Research's (NFCR) 2017 Szent-Györgyi Prize for Progress in Cancer Research winner, and David Sabatini, M.D., Ph.D., were named winners of the 2020 Sjöberg Prize "for their discovery of the target of rapamycin and the mammalian target of rapamycin, and their roles in the control of cell metabolism and growth."

28 Feb 2020

Combination therapy for pediatric low-grade gliomas shows promise in mice

In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas.

17 Feb 2020

Rapamycin News and Research

Common diabetes drug controls aspects of inflammation in mice

Study provides new insights into the host cellular response to SARS-CoV-2 infection

People with accelerated biological age at increased risk of COVID-19 symptom severity and mortality

Clemson researcher receives DOD grant to explore cellular underpinnings of developmental disorder

Researchers discover key signaling pathway in the pathogenesis of Paget's disease

Cell signaling pathway may offer new drugs for tuberous sclerosis complex

Researchers use human stem cell models to analyze degeneration in glaucoma

Researchers discover important molecular mechanism of Charcot-Marie-Tooth disease

Immune-regulating drug reverses dental problems in aging mice

Scientist proposes geroprotective strategies to reduce lethality of COVID-19 in the elderly

Insights into diagnosis and treatment of rare pediatric brain cancer

Rapamycin worsens diseases and premature aging in mice with short telomeres

Michael Hall named winner of 2020 Sjöberg Prize

Combination therapy for pediatric low-grade gliomas shows promise in mice

Researchers discover a way to restore strength of cardiac muscles in aging fruit flies

AI Therapeutics reports considerable progress on LAM-001 and LAM-004 clinical trials

FDA-approved drug to prevent organ rejection may slow skin aging

Rapamycin prevents age-related brain vascular deterioration, study shows

Scientists uncover how brain cells respond to and recover from lack of nutrition

Rapamycin is more effective at slowing down aging, says researcher

Delayed immune responses may be responsible for COVID-19 mortality rates

Are micro and nanoplastics accumulating in human organs and tissues?

A potential new way of treating Alzheimer’s Disease

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