Rapamycin is a drug used to prevent the rejection of organ and bone marrow transplants by the body. Rapamycin is an antibiotic that blocks a protein involved in cell division and inhibits the growth and function of certain T cells of the immune system involved in the body's rejection of foreign tissues and organs. It is a type of immunosuppressant and a type of serine/threonine kinase inhibitor. Rapamycin is now called sirolimus.
Researchers explored the association between the human microbiome and improved renal cell carcinoma outcomes.
In their evolutionary battle for survival, viruses have developed strategies to spark and perpetuate infection. Once inside a host cell, the Ebola virus, for example, hijacks molecular pathways to replicate itself and eventually make its way back out of the cell into the bloodstream, where it can spread further.
A new research perspective was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 2, entitled, "Are menopause, aging and prostate cancer diseases?"
Researchers investigated the CAMCI strategy as an immunotherapeutic option for inflammatory bowel disease.
Sepsis, one of the most acute and serious disease complications in the intensive care unit, is caused by various infections and results in life-threatening organ dysfunction.
Researchers explored ways galectins can impact immunity and discussed the opportunities and challenges in the field.
Researchers reported on the potential association between metformin usage and coronavirus disease 2019 (COVID-19) outcomes.
A new study published in the journal Science aimed to summarize the commonly studied anti-aging dietary interventions and their impact on human health and longevity.
In a recent study posted to the bioRxiv* server, researchers in Germany investigated the effectiveness of the antibiotic nitroxoline against the currently circulating mpox viruses, previously called monkeypox virus (MPXV). This antibiotic has been used in Europe for about fifty years and has been proven effective in fighting biofilm infections.
In a new study from the Johns Hopkins Kimmel Cancer Center, researchers described a novel mechanism of tumor formation in kidney cancers driven by overexpression of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway with loss of the tuberous sclerosis complex (TSC) tumor suppressor gene.
Discussed the current research on the role of molecular mechanisms in mediating immune priming in insects and regulating vector-borne disease transmission.
Three approaches with a reputation for slowing aging processes have proven largely ineffective. For their study, researchers developed a new method to measure aging, which accounts for the complexity of aging in organisms.
The effect of medicines on women and men can differ significantly. This also applies to the currently most promising anti-aging drug rapamycin, as researchers from the Max Planck Institute for Biology of Ageing in Cologne and University College London have now shown.
Scientists at Scripps Research have reported success in initial tests of a new, nanotech-based strategy against autoimmune diseases.
Findings from a new study published in Cell Reports, involving a collaborative effort between researchers at the Luikart Laboratory at Dartmouth's Geisel School of Medicine and the Weston Laboratory at the University of Vermont, are providing further insight into the neurobiological basis of autism spectrum disorders (ASD) and pointing to possible treatments.
The swine acute diarrhea syndrome coronavirus promotes autophagy to maintain its replication inside host cells.
Like bacteria, yeasts are found everywhere, even in and around our bodies. And, as with bacteria, you can become infected by yeasts and become ill. Yeasts infect about 150 million people a year and kill about 1.7 million, especially those who are immunocompromised.
Researchers review the potential role of the gut microbiome in determining severe COVID-19.
A new study shows that a brief treatment period could have the same anti-aging efficacy and duration of effect but without the potentially serious adverse effects of chronic administration.
Researchers evaluated the efficacy of honokiol in inhibiting SARS-CoV-2 replication in cell cultures.