Rapamycin News and Research

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Rapamycin is a drug used to prevent the rejection of organ and bone marrow transplants by the body. Rapamycin is an antibiotic that blocks a protein involved in cell division and inhibits the growth and function of certain T cells of the immune system involved in the body's rejection of foreign tissues and organs. It is a type of immunosuppressant and a type of serine/threonine kinase inhibitor. Rapamycin is now called sirolimus.

Study implicates placental protein as a possible regulator of an infant’s birthweight

New findings from the University of Minnesota Medical School are helping uncover why some people are more likely to be overweight and develop Type 2 diabetes -- and it starts in the womb.

10 Jun 2021

Rapamycin targets gut cells to alter the way DNA is stored

Our genetic material is stored in our cells in a specific way to make the meter-long DNA molecule fit into the tiny cell nucleus of each body cell.

10 Jun 2021

Study explores therapeutic potential of exploiting autophagy cascade against COVID-19

Researchers recently reviewed current knowledge on links between autophagy and coronaviruses and how this knowledge can be used to repurpose autophagy modulators as potential treatment options for COVID-19. The review is published in the journal Frontiers in Microbiology.

7 Jun 2021

Researchers identify new approach to clear toxic Huntingtin protein

Researchers world-wide are focused on clearing the toxic mutant Huntingtin protein that leads to neuronal cell death and systemic dysfunction in Huntington's disease (HD), a devastating, incurable, progressive neurodegenerative genetic disorder.

2 Jun 2021

Targeting mTOR pathway can improve the effectiveness of chemotherapies for pediatric brain cancer

Two experimental drug approaches that target vulnerabilities in cancer cell metabolism may extend survival and enhance the effectiveness of standard chemotherapies for a highly aggressive type of pediatric brain cancer.

21 May 2021

Study could help understand how Tuberous Sclerosis Complex arises

Tuberous Sclerosis Complex (TSC) affects between one and two of every 10,000 new-born babies. This genetic disease leads to the formation of benign tumors which can massively impair the proper functioning of vital organs such as the kidneys, the liver and the brain.

12 May 2021

Mutation in a cancer-causing gene could exacerbate cerebral cavernous malformations in the brain

Researchers have discovered an explanation for why cerebral cavernous malformations (CCMs)--clusters of dilated blood vessels in the brain--can suddenly grow to cause seizures or stroke.

28 Apr 2021

Can an immunosuppressive cancer drug promote SARS-CoV-2 entry into host cells?

A new study shows that rapamycin, an immunosuppressive drug used in some cancers, and its analogs, may have an undesirable effect on viral entry into the host cells. This finding could inform their use to treat symptomatic COVID-19.

20 Apr 2021

Type 2 diabetes drug can successfully reduce symptoms associated with tuberous sclerosis complex

A team of researchers led by UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital (GOSH) has found that metformin - a drug commonly used to treat Type 2 diabetes - can successfully reduce symptoms associated with tuberous sclerosis complex (TSC), including reduction in the frequency of seizures and the size of brain tumors.

29 Mar 2021

Malfunctioning blood-brain barrier is linked to benign forgetfulness of aging

Have you forgotten where you laid your keys? Ever wondered where you had parked your car? Or having trouble remembering the name of the new neighbor? Unfortunately, these things seem to get worse as one gets older.

19 Mar 2021

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

Metformin, a drug used to treat type-2 diabetes, could help reduce chronic inflammation in people living with HIV (PLWH) who are being treated with antiretroviral therapy (ART), according to researchers at the University of Montreal Hospital Research Centre.

18 Mar 2021

Minimally-invasive deep aging clocks could improve response to COVID-19 vaccine

Deep Longevity, a fully-owned subsidiary of Regent Pacific (SEHK:0575.HK), specializing in the development and the application of next-generation artificial intelligence (AI) for aging and longevity research, today announced the publication of an article in Lancet Healthy Longevity titled "The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19".

11 Feb 2021

Researchers call for trials of rapamycin to treat COVID-19

Researchers in the United States, China, and the UK have called for immediate large-scale clinical trials of an antibiotic called rapamycin as a prophylactic and treatment approach to coronavirus disease 2019 (COVID-19) in older individuals.

4 Feb 2021

Oncotarget publishes new research on geroscience

Dr. Mikhail V. Blagosklonny, M.D., Ph.D., Editor-in-Chief of Oncotarget, and Professor, at Roswell Park Cancer Institute, published "The goal of geroscience is life extension" which was selected as the Featured Cover Paper for Volume 12 Issue 3 and reported that although numerous drugs seemingly extend healthspan in mice, only a few extend lifespan in mice and only one does it consistently.

4 Feb 2021

Rapamycin News and Research

Study implicates placental protein as a possible regulator of an infant’s birthweight

Rapamycin targets gut cells to alter the way DNA is stored

Study explores therapeutic potential of exploiting autophagy cascade against COVID-19

Researchers identify new approach to clear toxic Huntingtin protein

Targeting mTOR pathway can improve the effectiveness of chemotherapies for pediatric brain cancer

Study could help understand how Tuberous Sclerosis Complex arises

Mutation in a cancer-causing gene could exacerbate cerebral cavernous malformations in the brain

Can an immunosuppressive cancer drug promote SARS-CoV-2 entry into host cells?

Type 2 diabetes drug can successfully reduce symptoms associated with tuberous sclerosis complex

Malfunctioning blood-brain barrier is linked to benign forgetfulness of aging

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

Minimally-invasive deep aging clocks could improve response to COVID-19 vaccine

Researchers call for trials of rapamycin to treat COVID-19

Oncotarget publishes new research on geroscience

Gene mutations may explain the poorer outcomes in Hispanic and Latino children with leukemia

G3BP proteins inhibit metabolic driver that plays a central role in cancers, neurological disorders

Anchor proteins inhibit a key metabolic driver that plays critical role in cancer and neuronal diseases

New method reveals how pharmaceuticals induce cancer cell death

Researchers demonstrate potential preventive treatment for Crohn's disease

Study offers new clues to the pathogenesis of glaucoma

Does the number of siblings you have affect your health?

International Day of Action for Women’s Health: An Interview with Dame Claire Bertschinger

International Day of Action for Women’s Health: An Interview with UN Women

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