Rapamycin is a drug used to prevent the rejection of organ and bone marrow transplants by the body. Rapamycin is an antibiotic that blocks a protein involved in cell division and inhibits the growth and function of certain T cells of the immune system involved in the body's rejection of foreign tissues and organs. It is a type of immunosuppressant and a type of serine/threonine kinase inhibitor. Rapamycin is now called sirolimus.
Study reveals that senolytics can reduce aging in human brain organoids and mitigate COVID-19 neuropathology, suggesting their potential as a therapeutic strategy against brain aging and coronavirus-related neurological complications.
This comprehensive review in Nutrients explores yogurt as a protein source, highlighting its beneficial effects on skeletal muscle health and digestibility compared to milk. The study suggests that yogurt not only aids in muscle protein synthesis but could also be advantageous in maintaining muscle mass during weight loss programs.
Researchers examine the mechanisms responsible for the increased risk of neurocognitive impairment in HIV patients and explore potential treatments.
In a significant randomized clinical trial, early metformin therapy was tested for its potential to lessen insulin dependence and enhance glycemic control in gestational diabetes-afflicted pregnant women; however, it yielded no improvements in diabetes symptoms. While metformin reduced maternal weight gain, its effects on primary diabetes symptoms and other secondary outcomes like infant weight gain were mixed, indicating a need for further focused research to unravel these associations.
Micro-ribonucleic acids (miRNAs) linked to cognition and Alzheimer's disease (AD).
To make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third small molecule is added.
The Buck Institute for Research on Aging has received a $3.5 million federal grant to lead the first-ever double-blind, randomized, placebo-controlled clinical trial to understand the effects of ketone ester supplementation on frailty, a condition of vulnerability which develops following age-related decline in multiple physiological systems.
Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.
Researchers review existing evidence on the association between estrogen, osteoarthritis, and lower back pain.
The application of proteomics-driven biomarkers for early detection, diagnosis, and treatment of pancreatic cancer.
Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.
A group of authors summarized adjuvant mechanisms, characteristics, and applications, seeking to overcome current vaccine limitations.
A team led by researchers at the Mechanisms of Inherited Kidney Disorders (MIKADO) group at the University of Zurich (Zurich, Switzerland) has used Insilico Medicine's generative artificial intelligence (AI) target discovery engine, PandaOmics, to identify actionable drug targets for the lysosomal storage disease cystinosis and to validate them in preclinical models of the disease.
Artificial intelligence is becoming increasingly important in drug discovery. Advances in the use of Big Data, learning algorithms and powerful computers have now enabled researchers at the University of Zurich (UZH) to better understand a serious metabolic disease.
Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.
According to the federal government's National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide -; with almost a third in the United States -; are living with multiple sclerosis (MS), a disabling neurological disease in which the body's immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.
More than 40% of Americans are considered obese, and the trend continues to grow. The treatments or preventive options for obesity and obesity-associated diseases are limited.
The first protein-based nano-computing agent that functions as a circuit has been created by Penn State researchers.
A new research perspective was published in Oncotarget's Volume 14 on April 14, 2023, entitled, "Cancer prevention with rapamycin."