Rapamycin News and Research

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Rapamycin is a drug used to prevent the rejection of organ and bone marrow transplants by the body. Rapamycin is an antibiotic that blocks a protein involved in cell division and inhibits the growth and function of certain T cells of the immune system involved in the body's rejection of foreign tissues and organs. It is a type of immunosuppressant and a type of serine/threonine kinase inhibitor. Rapamycin is now called sirolimus.

Cultivating strength: How yogurt boosts skeletal muscle health

This comprehensive review in Nutrients explores yogurt as a protein source, highlighting its beneficial effects on skeletal muscle health and digestibility compared to milk. The study suggests that yogurt not only aids in muscle protein synthesis but could also be advantageous in maintaining muscle mass during weight loss programs.

16 Oct 2023

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Researchers examine the mechanisms responsible for the increased risk of neurocognitive impairment in HIV patients and explore potential treatments.

12 Oct 2023

Early metformin therapy falls short in curbing gestational diabetes woes

In a significant randomized clinical trial, early metformin therapy was tested for its potential to lessen insulin dependence and enhance glycemic control in gestational diabetes-afflicted pregnant women; however, it yielded no improvements in diabetes symptoms. While metformin reduced maternal weight gain, its effects on primary diabetes symptoms and other secondary outcomes like infant weight gain were mixed, indicating a need for further focused research to unravel these associations.

4 Oct 2023

Identification of Alzheimer's disease-associated micro-RNA biomarkers through network-based analysis

Micro-ribonucleic acids (miRNAs) linked to cognition and Alzheimer's disease (AD).

3 Oct 2023

Evidence reveals ferroptosis's critical role in male reproductive health

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2 Oct 2023

Rice engineers develop split gene-editing tool with enhanced control

To make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third small molecule is added.

21 Sep 2023

Buck Institute receives $3.5 million federal grant to lead clinical trial of ketone intervention in older adults

The Buck Institute for Research on Aging has received a $3.5 million federal grant to lead the first-ever double-blind, randomized, placebo-controlled clinical trial to understand the effects of ketone ester supplementation on frailty, a condition of vulnerability which develops following age-related decline in multiple physiological systems.

11 Sep 2023

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

The role of estrogen in osteoarthritis and lower back pain

Researchers review existing evidence on the association between estrogen, osteoarthritis, and lower back pain.

10 Aug 2023

What are some recent advancements in proteomics-driven pancreatic oncology research?

The application of proteomics-driven biomarkers for early detection, diagnosis, and treatment of pancreatic cancer.

9 Aug 2023

Researchers discover how aging can lead to chronic metabolic disorders

Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.

3 Aug 2023

Advancing vaccine adjuvants: exploring cutting-edge platforms for improved immunization

A group of authors summarized adjuvant mechanisms, characteristics, and applications, seeking to overcome current vaccine limitations.

21 Jul 2023

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

A team led by researchers at the Mechanisms of Inherited Kidney Disorders (MIKADO) group at the University of Zurich (Zurich, Switzerland) has used Insilico Medicine's generative artificial intelligence (AI) target discovery engine, PandaOmics, to identify actionable drug targets for the lysosomal storage disease cystinosis and to validate them in preclinical models of the disease.

14 Jul 2023

AI-powered drug discovery offers hope for cystinosis patients

Artificial intelligence is becoming increasingly important in drug discovery. Advances in the use of Big Data, learning algorithms and powerful computers have now enabled researchers at the University of Zurich (UZH) to better understand a serious metabolic disease.

14 Jul 2023

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.

12 Jun 2023

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

According to the federal government's National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide -; with almost a third in the United States -; are living with multiple sclerosis (MS), a disabling neurological disease in which the body's immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.

6 Jun 2023

Rapamycin News and Research

Cultivating strength: How yogurt boosts skeletal muscle health

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Early metformin therapy falls short in curbing gestational diabetes woes

Identification of Alzheimer's disease-associated micro-RNA biomarkers through network-based analysis

Evidence reveals ferroptosis's critical role in male reproductive health

Rice engineers develop split gene-editing tool with enhanced control

Buck Institute receives $3.5 million federal grant to lead clinical trial of ketone intervention in older adults

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

The role of estrogen in osteoarthritis and lower back pain

What are some recent advancements in proteomics-driven pancreatic oncology research?

Researchers discover how aging can lead to chronic metabolic disorders

Advancing vaccine adjuvants: exploring cutting-edge platforms for improved immunization

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

AI-powered drug discovery offers hope for cystinosis patients

Metformin shows promising antiviral activity against SARS-CoV-2

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

Study identifies a novel druggable signaling molecule involved in obesity and diabetes

Penn State researchers create first protein-based nano-computing agent

Rapamycin and other rapalogs have potential to delay cancer

Promoting cellular recycling in the brain may reverse or prevent damage from traumatic brain injury

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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