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Merck releases statement on FDA's Advisory Committee meeting about suvorexant

Merck, known as MSD outside the United States and Canada, today provided the following statement after the conclusion of the Peripheral and Central Nervous System Drugs Advisory Committee meeting of the U.S. Food and Drug Administration about suvorexant, Merck's investigational medicine to treat insomnia.

23 May 2013

European, US NSTE-ACS guidelines recommend bivalirudin alone in patients undergoing PCI

Results from a large observational study reported at EuroPCR 2013 today question whether bivalirudin is superior to heparin in the absence of GPIIb/IIIa blockade, showing similar 30-day mortality in patients with non-ST segment elevation acute coronary syndromes undergoing percutaneous coronary intervention.

23 May 2013

Cancer experts to discuss latest developments and implications of cell therapies in oncology

John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's top 50 cancer centers, will bring together leading cancer experts, for presentation and discussion of the latest developments and implications of cell therapy and interventional immunology in oncology, on Friday, June 7 from 7:00am to 1:30pm.

23 May 2013

Naloxegol meets primary and secondary endpoints in two pivotal Phase III studies

AstraZeneca today presented the results of two pivotal Phase III studies of naloxegol showing the 25 mg dose of the investigational drug met its primary and secondary endpoints for efficacy and showed a safety profile consistent with previous studies.

22 May 2013

Emory University researchers identify a protein that stimulates orphan receptors in the brain

Researchers at Emory University have identified a protein that stimulates a pair of "orphan receptors" found in the brain, solving a long-standing biological puzzle and possibly leading to future treatments for neurological diseases.

22 May 2013

Exercise-induced bronchoconstriction (EIB) guidelines: an interview with Dr Jonathan Parsons, The Ohio State University Asthma Center

Exercise-induced bronchospasm (EIB) is defined as acute, transient airway narrowing that occurs in association with exercise. Exercise-induced bronchospasm can occur during or, more frequently, after exercise.

21 May 2013

AbbVie starts Phase 3 clinical study of atrasentan in patients with diabetic nephropathy

AbbVie announced today the initiation of a Phase 3 clinical study called SONAR (Study Of Diabetic Nephropathy with Atrasentan) to assess the effects of the investigational compound atrasentan - when added to standard of care - on progression of kidney disease in patients with stage 2 to 4 chronic kidney disease and type 2 diabetes.

21 May 2013

UTMB researchers awarded grant to study gene therapy techniques to eliminate neuropathic pain

University of Texas Medical Branch at Galveston researchers have been awarded a five-year, $1.8 million grant by the National Institute of Neurological Disorders and Stroke to apply the techniques of gene therapy to the problem of neuropathic pain - that is, pain that arises from a malfunction in the nervous system.

21 May 2013

Newer class of diabetes medications may also improve cardiovascular health, researchers report

A newer class of medications used to control blood sugar levels in type 2 diabetics may also improve cardiovascular health, researchers from The Ohio State University Wexner Medical Center reported in a new meta-analysis presented yesterday at the American Society of Hypertension's Annual Scientific Meeting and Exposition.

17 May 2013

Insero Health announces top-line Phase Ib trial results of INS001 in patients with drug-resistant epilepsy

Insero Health, Inc., a company developing natural compounds to address unmet medical needs in epilepsy and related neurological disorders, is today reporting top-line results from a Phase Ib trial of its lead compound INS001 in patients with drug-resistant epilepsy.

17 May 2013

PCF funds two new Young Investigators in China to lead research projects on prostate cancer

The Prostate Cancer Foundation today announced that it is funding two more Young Investigators in China to lead innovative research projects within the country and expand PCF's global knowledge exchange on game-changing research in prostate cancer.

17 May 2013

Researchers reveal new molecular mechanisms that resist visceral leishmaniasis

Researchers from CNRS, Université Toulouse III - Paul Sabatier and IRD have elucidated new molecular mechanisms involved in resistance to visceral leishmaniasis, a serious parasitic infection.

16 May 2013

Study suggests need for better anti-rejection therapies

Transplant researchers at the University of Pittsburgh School of Medicine challenge a long-held assumption about how biologic pathways trigger immune system rejection of donor organs in a report published online today in the Journal of Clinical Investigation.

16 May 2013

Avian-origin influenza A virus associated with severe lower respiratory tract diseases

A novel avian-origin reassortant influenza A (H7N9) virus emerged in China in February 2013, and is associated with severe lower respiratory tract diseases. To date, more than 100 human cases of infection, including at least 20 deaths, have been reported in China.

15 May 2013

Sanofi, Regeneron enroll patients in two sarilumab Phase 3 trials for treatment of RA

Sanofi and Regeneron Pharmaceuticals, Inc. today announced that the COMPARE and ASCERTAIN trials of sarilumab, the first fully human monoclonal antibody directed against the IL-6 receptor, which is delivered by subcutaneous injection every other week, have enrolled their first patients.

15 May 2013

New study reveals another duet played by Notch and BMP signals

A small ensemble of musicians can produce an infinite number of melodies, harmonies and rhythms. So too, do a handful of workhorse signaling pathways that interact to construct multiple structures that comprise the vertebrate body.

15 May 2013

FDA OKs TWi Pharmaceuticals' tentative ANDA for Guanfacine Hydrochloride Extended Release Tablets

TWi Pharmaceuticals, Inc. today announced that it has received tentative approval for its Abbreviated New Drug Application for Guanfacine Hydrochloride Extended Release Tablets 1mg, 2mg, 3mg and 4mg from the United States Food and Drug Administration.

14 May 2013

Discovery provides vital clues for new antibiotics against MRSA

Scientists at Imperial College London have identified four new proteins that act as receptors for an essential signalling molecule in bacteria such as MRSA.

14 May 2013

Cancers physically alter cells in lymphatic system to promote the spread of disease

Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system - a network of vessels that transports and stores immune cells throughout the body - to promote the spread of disease, a process called metastasis.

14 May 2013

Chinese scientists suggest strong measures to prevent a possible pandemic

On 31 March 2013, the Chinese National Health and Family Planning Commission announced human cases of novel H7N9 influenza virus infections.

14 May 2013

Receptor News and Research

Merck releases statement on FDA's Advisory Committee meeting about suvorexant

European, US NSTE-ACS guidelines recommend bivalirudin alone in patients undergoing PCI

Cancer experts to discuss latest developments and implications of cell therapies in oncology

Naloxegol meets primary and secondary endpoints in two pivotal Phase III studies

Emory University researchers identify a protein that stimulates orphan receptors in the brain

Exercise-induced bronchoconstriction (EIB) guidelines: an interview with Dr Jonathan Parsons, The Ohio State University Asthma Center

AbbVie starts Phase 3 clinical study of atrasentan in patients with diabetic nephropathy

UTMB researchers awarded grant to study gene therapy techniques to eliminate neuropathic pain

Newer class of diabetes medications may also improve cardiovascular health, researchers report

Insero Health announces top-line Phase Ib trial results of INS001 in patients with drug-resistant epilepsy

PCF funds two new Young Investigators in China to lead research projects on prostate cancer

Researchers reveal new molecular mechanisms that resist visceral leishmaniasis

Study suggests need for better anti-rejection therapies

Avian-origin influenza A virus associated with severe lower respiratory tract diseases

Sanofi, Regeneron enroll patients in two sarilumab Phase 3 trials for treatment of RA

New study reveals another duet played by Notch and BMP signals

FDA OKs TWi Pharmaceuticals' tentative ANDA for Guanfacine Hydrochloride Extended Release Tablets

Discovery provides vital clues for new antibiotics against MRSA

Cancers physically alter cells in lymphatic system to promote the spread of disease

Chinese scientists suggest strong measures to prevent a possible pandemic

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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