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Benefits of less intensive stem cell transplants for sickle cell disease

So-called low-intensity blood stem cell transplants, which use milder conditioning agents than standard stem cell transplants, do not appear to damage the lungs and may help improve lung function in some patients with sickle cell disease (SCD), according to a three-year study of adults who underwent the procedure at the National Institutes of Health (NIH).

28 Aug 2024

Research unveils how HMGA2 regulates stress responses in stem cells

Kumamoto University researchers have made a groundbreaking discovery that sheds light on how the HMGA2 gene-;an essential transcriptional activator involved in chromatin modification-;regulates stress responses in hematopoietic stem cells (HSCs), thereby enhancing blood cell production recovery.

22 Aug 2024

Spatial transcriptomics unlocks malaria's liver stage secrets

For the malaria parasite to reach the blood of its human host, it must first enter the liver, where only a small number of parasites differentiate and replicate for upwards of seven days, making it a bottleneck in the parasite's lifecycle. This bottleneck makes the liver stage an optimal target for effective and long-lasting vaccines against the disease. Using Spatial Transcriptomics and single-cell RNA-sequencing technologies, researchers at Stockholm University have for the first time managed to create a spatio-temporal map of malaria infection in the mouse liver. A study that was recently published in Nature Communications.

21 Aug 2024

Study reveals time-of-day impact on cerebral malaria severity

A discovery by McGill-affiliated researchers could lead to more effective treatment of malaria and other parasitic diseases.

19 Aug 2024

ANU researchers develop cholesterol-based trojan horse method to target malaria parasites

More than a quarter of Australians over the age of 50 take cholesterol-lowering drugs to prevent heart disease and strokes, but our bodies also need cholesterol to survive.

13 Aug 2024

Investigational drug shows promise in treating rare blood disease in fetuses

Data from a new investigational drug that could alter the standard treatment for a rare blood disease suggests it has the potential to delay or prevent anemia and the need for intrauterine blood transfusions in babies who are at high risk for the condition, known as Hemolytic Disease of the Fetus and Newborn (HDFN).

7 Aug 2024

Decreasing folate intake can support healthier metabolisms in aging animal models

In a study published in Life Science Alliance, Texas A&M AgriLife Research scientists found that decreasing folate intake can support healthier metabolisms in aging animal models, challenging the conventional belief that high folate consumption universally benefits health.

2 Aug 2024

AI unlocks potential of antimicrobial peptides for new antibiotics

In a hopeful sign for demand for more safe, effective antibiotics for humans, researchers at The University of Texas at Austin have leveraged artificial intelligence to develop a new drug that already is showing promise in animal trials.

1 Aug 2024

Study: Iron infusions superior to blood transfusions for surgical patients with anemia

In a rigorous medical records study covering tens of thousands of patients, Johns Hopkins Medicine researchers conclude that some patients with preoperative anemia have better outcomes if they get iron infusions before surgery rather than standard red blood cell transfusions.

25 Jul 2024

Omega-3 fatty acids found to significantly reduce acne in new study

Recent research highlights that omega-3 fatty acids significantly reduce acne severity. Supplementation and a Mediterranean diet improved skin condition in most study participants.

16 Jul 2024

Decoding the significance of subnormal liver enzyme activity

Liver diseases are commonly diagnosed using serum enzyme assays, particularly for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), and 5'-nucleotidase (5'-NT).

3 Jul 2024

Role of SMIM1 gene in obesity uncovered

Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese.

20 Jun 2024

Mathematical modeling reveals hemoglobin's role in silent hypoxemia of COVID-19

Since 2020, the COVID-19 pandemic has presented significant challenges to global public health, infecting millions and claiming numerous lives.

18 Jun 2024

Montana creates emergency ‘drive-thru’ blood pickup service for rural ambulances

Crystal Hiwalker wonders if her heart and lungs would have kept working if the ambulance crew had been able to give her a transfusion as the blood drained from her body during a stormy, 100-mile ride.

17 Jun 2024

Promising gene editing therapy shows hope in sickle cell disease cure

Researchers have presented the latest findings from a clinical trial aimed at discovering a cure for sickle cell disease, a painful genetic blood disorder with limited treatment options.

14 Jun 2024

St. Jude researchers uncover NLRC5's role in immune response and cell death

The innate immune system is responsible for protecting the human body from threats that could cause disease or infection.

14 Jun 2024

Study advocates for liberal blood transfusions in TBI intensive care

Increased use of blood transfusions after major traumatic brain injury could help people hospitalized in intensive care units regain greater functional independence and a better quality of life.

13 Jun 2024

AI revolutionizes malaria diagnosis with 97.57% accuracy using EfficientNet

AI tool that uses deep learning to examine red blood cell images in blood smears for the timely detection of malaria.

12 Jun 2024

Inherited iron defects uncovered in endemic Indian population

Although iron deficiency anemia is the most prevalent form of anemia globally, it may be underdiagnosed due to lack of awareness or methodical screening.

20 May 2024

Acetaminophen shows potential in preventing acute respiratory distress syndrome, organ injury in sepsis patients

A National Institutes of Health (NIH)-supported clinical trial has found that intravenous acetaminophen reduced sepsis patients' risk of having organ injury or developing acute respiratory distress syndrome, a serious condition that allows fluid to leak into the lungs.

20 May 2024