Regulatory RNA News and Research

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SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes respiratory coronavirus disease 2019 (COVID-19) triggered an unprecedented public health emergency. Human mobility patterns were fundamental to the spread of SARS-CoV-2 globally. The situation is particularly acute in a country like Saudi Arabia, which has seen more than 750,000 cases and over 9,000 deaths as of March 30th, 2022.

29 Mar 2022

Study explores favorable signatures for specific RNA motif recognition by SARS-CoV-2 nucleocapsid

A new study evaluated the N terminal domain of the SARS-CoV-2 nucleocapsid protein. It presented the targeted characteristics for selective ribonucleic acid identification by SARS-CoV-2 N in its 5'-genomic end.

24 Mar 2022

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

In a recent study published in CANCER RESEARCH , a team led by researchers at Tokyo Medical and Dental University (TMDU) identified a specific small RNA molecule, called a microRNA (miRNA or miR), that has the potential to be used as an anti-cancer therapeutic.

5 Oct 2021

Researchers identify potential new treatment for osteoarthritis

Osteoarthritis (OA) is a debilitating joint disease that affects millions of individuals worldwide. Common in the older adult population, OA is associated with loss of cartilage over time.

26 Aug 2021

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

The study, published in the journal Angewandte Chemie International Edition, identified many small molecules that bind to certain parts of the SARS-CoV-2 genome that are less likely altered by mutations using dedicated substance libraries. The scientists derived key functional units and groups in ligands for effective and safe targeting of SARS-CoV-2 RNA.

22 Jul 2021

Researchers find a promising avenue for more effective treatment of antibiotic-resistant bacteria

A small regulatory RNA found in many problematic bacteria, including Escherichia coli, appears to be responsible for managing the response of these bacteria to environmental stresses.

15 Jul 2021

AACR and MPM award three grants to support groundbreaking cancer research projects

Three grants for research that could transform cancer therapies have been awarded by the AACR-MPM Oncology Charitable Foundation Transformative Cancer Research Grants Program, an innovative partnership between the American Association for Cancer Research and the UBS Oncology Impact Fund managed by MPM Capital.

21 Jan 2021

RNA-binding proteins may suppress antiviral defenses against SARS-CoV-2

Conducted by researchers in South Korea at the Institute for Basic Science and the International Vaccine Institute, a new study published on the preprint server bioRxiv in November 2020 describes the many host proteins that bind with the ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and regulate the replication of the virus.

4 Nov 2020

New optical switch to precisely control the lifespan of genetic 'copies'

A novel optical switch makes it possible to precisely control the lifespan of genetic "copies". These are used by the cell as building instructions for the production of proteins.

25 Sep 2020

Mapping RNA sequences of therapeutic value in the SARS-CoV-2 genome

Now, in new research published on the preprint server bioRxiv European scientists have performed RNA structure probing to obtain a single-base resolution secondary structure map of the full SARS-CoV-2 coronavirus genome.

17 Jun 2020

Developing new approaches to fight against multi-resistant pathogens

Developing fundamentally new approaches against multi-resistant germs: This is the goal of the new Bavarian research network bayresq.net which started in January 2020.

9 Feb 2020

New discovery changes the understanding of gene expression

A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality.

22 Jan 2020

Researchers discover how bacterial pathogens switch into attack mode

Many bacterial pathogens excrete toxins as soon as they have entered the host in order to suppress its immune response.

21 Jan 2020

Researchers discover new and rare skeletal disease

Researchers at Karolinska Institutet in Sweden have discovered a new and rare skeletal disease. In a study published in the journal Nature Medicine they describe the molecular mechanism of the disease, in which small RNA molecules play a role that has never before been observed in a congenital human disease.

25 Feb 2019

Researchers discover new approach for treatment of myotonic dystrophy

Researchers at the Translational Genomics laboratory of Valencia University and the INCLIVA health research institute have just discovered a new approach for the treatment of myotonic dystrophy, a rare and incurable neuromuscular disease which does not have specific treatment.

27 Jun 2018

Garlic compound can combat robust bacteria in patients with chronic infections

An active sulphurous compound found in garlic can be used to fight robust bacteria in patients with chronic infections, a new study from the University of Copenhagen indicates.

28 Nov 2017

Researchers identify new class of regulatory RNAs involved in cancer pathologies

A team of researchers at the Institute of Oncology Research has identified a new class of regulatory RNAs, which are able to act as molecular switches and can contribute in controlling the genetic evolution processes that are responsible for some cancer pathologies.

7 Jun 2017

Researchers explore ways to tamper reproductive events in dengue- and Zika-spreading mosquito

The mosquito Aedes aegypti, which can spread dengue fever, chikungunya, Zika fever, and yellow fever virus, requires a blood meal to develop eggs.

22 Feb 2017

Würzburg researchers discover long-suspected third RNA binding protein

Small regulatory RNA molecules are vital for salmonella and other bacteria potentially harmful to humans: This RNA type controls gene activity and allows bacteria to quickly adjust to changing conditions of living and stress as are typical during an infection, for example, when entering the blood stream or inside human cells.

17 Oct 2016

Drexel University researchers aim to identify new molecular mechanisms involved in chronic pain

Chronic pain is one of the most prevalent, disabling and expensive public health crises in the United States. It affects more than 100 million Americans, with annual costs estimated at $635 billion, says a 2014 report from the American Pain Society.

22 Jun 2016