Researchers identify new class of regulatory RNAs involved in cancer pathologies

A team of researchers at the Institute of Oncology Research (IOR, affiliated with USI Faculty of Biomedical Sciences) has identified a new class of regulatory RNAs, which are able to act as molecular switches and can contribute in controlling the genetic evolution processes that are responsible for some cancer pathologies.  

The study, led by IOR Director Prof. Carlo Catapano and published on the scientific journal Nature Communications, has put together different data from various experimental models and clinical specimens, showing that a specific regulatory RNA could contribute to epigenetic silencing (change in heritability) of an important gene able to protect the prostate cells from potentially cancerous mutations.

The RNA is a polymeric molecule essential in various biological roles in coding, decoding, regulation of genes. Together with the DNA it constitutes one of the major macromolecules essential for all known forms of life.According to researchers, the use of RNAs as targets could limit the onset of cancer.

The research operates in an emerging and interesting study area for both understanding tumor transformation processes, and for the development of possible clinical applications for diagnostic, prognostic and therapeutic purposes. According to Prof. Carlo Catapano: "The study has shown for the first time the interconnection between genetic alterations, structure and function of regulatory RNAs and epigenetic processes. This means that in a near future, thanks to medications acting on these "targets", we will be able to intervene on the underlying genetic conditions, therefore preventing or slowing down cancer development".


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Breakthrough in aging research: Blocking IL-11 extends lifespan and improves health in mice