Respiratory News and Research

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Disproportionate number of SARS-CoV-2 breakthrough infections are caused by variants of concern

A study conducted by researchers in the United States has shown that among twenty patients with breakthrough infection following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – all of the infections were caused by variants of concerns.

26 May 2021

Reducing COVID-19 burden with monoclonal antibodies and vaccination

Researchers in the United States, the UK and France have shown that using antiviral monoclonal antibodies in combination with vaccination can be expected to suppress the transmission of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) and reduce the burden of coronavirus disease 2019 (COVID-19) more than vaccination alone.

26 May 2021

Will SARS-CoV-2 eventually become just another seasonal coronavirus?

Could SARS-CoV-2 become just a seasonal nuisance in the next decade, causing just coughs and sniffles like a common cold, suggests new research? Scientists at the University of Utah, USA, tried to predict the possible future of the novel coronavirus using mathematical models that use learnings from the current pandemic on changes in human immunity over time.

26 May 2021

CASdetec: new CRISPR-based SARS-CoV-2 detection platform detects nucleic acids with high sensitivity and specificity

To add to existing CRISPR-based nucleic acid detection protocols, a team of researchers recently established a new SARS-CoV-2 detection protocol based on their previously reported platform - CDetection (Cas12b-mediated DNA detection). They combined nucleic-acid amplification methods and sample treatment protocols with CDetection and established an integrated nucleic acid detection platform called CRISPR-assisted detection or CASdetec. CASdetec has a detection limit of 1×104 copies/mL for SARS-CoV-2 pseudovirus, without any observed cross-reactivity.

26 May 2021

Tsimane's brains experience less brain atrophy than Westerners as they age, indicates study

A team of international researchers has found that the Tsimane indigenous people of the Bolivian Amazon experience less brain atrophy than their American and European peers.

26 May 2021

New COVID-19 test can deliver highly accurate results in less than 15 minutes

A new rapid coronavirus test developed by KAUST scientists can deliver highly accurate results in less than 15 minutes.

26 May 2021

Intensity and duration of SARS-CoV-2 immunity may depend on ABO blood group

A team of scientists from Canada and Spain recently evaluated the durability of antigen-specific immune responses in COVID-19 recovered individuals. They have also identified potential host factors associated with robust and long-lasting anti-SARS-CoV-2 immunity.

26 May 2021

Researchers develop a method to detect SARS-CoV-2 and variants simultaneously

Researchers demonstrate a method of detecting the presence and mutations in the SARS-CoV-2 virus using the smaller and cheaper Oxford Nanopore sequencer, a method they believe could make pandemic surveillance faster and cheaper.

26 May 2021

Could GRP78 be a therapeutic target against COVID-19?

A new study by a team of researchers at the Keck School of Medicine, University of Southern California, USA, reports a potentially important therapeutic target in the form of a molecule called GRP78 that promotes the entry and protein production by many viruses. The team's paper has been published in the Journal of Biological Chemistry.

26 May 2021

New SARS-CoV-2 variants emerge among children in United States, suggests study

As the coronavirus disease 2019 (COVID-19) pandemic approaches its eighteenth month, new variants of concern (VOCs) of the causative pathogen – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – continue to emerge all over the world. A new study explores the emergence of such VOCs among young children, below 12 years of age, and the potential consequences of this phenomenon.

26 May 2021

Tissue-resident memory T cells found in lungs of people who had COVID-19 10 months ago

In recent research by Judith Grau-Expósito et al., scientists identify circulating virus-specific T cell responses during acute SARS-CoV-2 infection with functional, migratory, and apoptotic patterns modulated by viral proteins and associated with clinical outcome.

26 May 2021

Zoonotic and vector-borne emerging tropical diseases pose a constant threat

A recent article published in the journal Frontiers in Tropical Diseases assessed the threat of emerging zoonotic and vector-borne tropical diseases.

26 May 2021

Non-droplet routes of SARS-CoV-2 transmission

In a recent review article published in the Science of The Total Environment journal, a group of Polish researchers discussed the different transmission routes of the severe acute respiratory coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19). In their work, the researchers focused on the extent of SARS-CoV-2 survival in the environment, particularly in sewages and contaminated surfaces.

26 May 2021

Researchers synthesize potential drugs with anti-cancer effects

New effective compounds, which can be endogenous donors of a signaling molecule - hydrogen sulfide in the body, were synthesized by SUSU scientists. Due to this property, the obtained compounds are potential drugs with a cancer-preventing effect.

26 May 2021

An exploratory study of T-cell and antibody responses after COVID-19 mRNA vaccination

Recent COVID-19 investigations have found that up to half of immunocompromised individuals struggle to produce antibodies after receiving their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations.

26 May 2021

Previous H3N2 influenza A infection may explain some cases of severe COVID-19

According to research from the University of California, some cases of severe coronavirus disease 2019 (COVID-19) may be related to the immunological memory of previous H3N2 influenza A infection.

26 May 2021

Moderna's COVID vaccine proves effective against South African variant in primates

Researchers in the United States have demonstrated the efficacy of Moderna’s coronavirus disease 2019 (COVID-19) vaccine at protecting against the South African B.1.351 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in non-human primates.

26 May 2021

Study attempts to standardize humoral immune Correlates of Protection (CoP) in COVID-19

A new study aims to identify antibody-based biomarkers associated with the humoral immune response that could be a standard CoP candidate for COVID-19. Further, standardization of research methods to measure these biomarkers has also been conducted.

25 May 2021

Researchers develop a novel probiotic formulation with high anti-SARS-CoV-2 potency

A team of international scientists recently conducted a randomized clinical trial to assess the safety and efficacy profiles of a novel probiotic formulation in symptomatic coronavirus disease 2019 (COVID-19) patients. The findings indicate that the probiotic formulation is highly effective in reducing symptom severity in COVID-19 patients without causing any adverse events.

25 May 2021

Repurposed gout medication (probenecid) shows potent inhibition of SARS-CoV-2 replication

New research by a team of scientists in the USA describes the potential utility of a drug called probenecid, commonly used to treat gout, to treat this devastating viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative virus of COVID-19.

25 May 2021

Respiratory News and Research

Disproportionate number of SARS-CoV-2 breakthrough infections are caused by variants of concern

Reducing COVID-19 burden with monoclonal antibodies and vaccination

Will SARS-CoV-2 eventually become just another seasonal coronavirus?

CASdetec: new CRISPR-based SARS-CoV-2 detection platform detects nucleic acids with high sensitivity and specificity

Tsimane's brains experience less brain atrophy than Westerners as they age, indicates study

New COVID-19 test can deliver highly accurate results in less than 15 minutes

Intensity and duration of SARS-CoV-2 immunity may depend on ABO blood group

Researchers develop a method to detect SARS-CoV-2 and variants simultaneously

Could GRP78 be a therapeutic target against COVID-19?

New SARS-CoV-2 variants emerge among children in United States, suggests study

Tissue-resident memory T cells found in lungs of people who had COVID-19 10 months ago

Zoonotic and vector-borne emerging tropical diseases pose a constant threat

Non-droplet routes of SARS-CoV-2 transmission

Researchers synthesize potential drugs with anti-cancer effects

An exploratory study of T-cell and antibody responses after COVID-19 mRNA vaccination

Previous H3N2 influenza A infection may explain some cases of severe COVID-19

Moderna's COVID vaccine proves effective against South African variant in primates

Study attempts to standardize humoral immune Correlates of Protection (CoP) in COVID-19

Researchers develop a novel probiotic formulation with high anti-SARS-CoV-2 potency

Repurposed gout medication (probenecid) shows potent inhibition of SARS-CoV-2 replication

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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