Retinoic Acid News and Research

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Retinoic Acid is a nutrient that that body needs in small amounts to function and stay healthy. All-trans retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of all-trans retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). All-trans retinoic acid is being studied in the prevention and treatment of other types of cancer. Also called ATRA, retinoic acid, tretinoin, and vitamin A acid.

Scientists discover novel defensive response to SARS-CoV-2

Scientists from Hokkaido University have discovered a novel defensive response to SARS-CoV-2 that involves the viral pattern recognition receptor RIG-I. Upregulating expression of this protein could strengthen the immune response in COPD patients.

21 May 2021

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer's disease in mice.

22 Apr 2021

Researchers provide experimental evidence for synaptic plasticity in the human brain

Neuroscientists agree that a person's brain is constantly changing, rewiring itself and adapting to environmental stimuli.

31 Mar 2021

SARS-CoV-2 inhibits the cellular response to interferon

Researchers have explored the effect of SARS-CoV-2 infection on the function of RIG-I and MDA5, and ultimately on interferon production.

31 Mar 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

Researchers develop a simple and efficient way to generate hemogenic endothelial cells

Pioneering research into how our bodies manufacture the cells that make blood has moved us closer to regrowing tissues and organs. The findings also may let doctors grow the cells for transplantation into people to battle cancer, blood disorders and autoimmune diseases.

28 Jan 2021

The role of micro-RNA in SARS-CoV-2 infection and COVID-19

A team of researchers based in Iran have explored the role of micro-RNA in COVID-19. Their study titled, “The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection,” was published in the latest issue of the journal International Immunopharmacology.

24 Nov 2020

Genomic adaptations to rice‐based diets contribute to mitigation of metabolic risk

The traditional rice-based diet of some east-Asian population has brought to a number of genomic adaptations that may contribute to mitigating the spread of diabetes and obesity.

21 Sep 2020

Acne drug could be a potential treatment for dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, affecting 1 in 250 people. The disease is characterised by an increase in size of the left ventricle of the heart.

8 Sep 2020

Study: MafB protein may protect against renal failure

Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant nephrotic syndrome, a type of kidney disease that is accompanied by massive urinary protein loss and that may progress to end-stage renal disease.

5 Jun 2020

Genetic variations linked to COVID-19 severity

A new report by researchers from Thailand's Mahidol University and published on the preprint server medRxiv in May 2020 reports that the clinical severity of COVID-19 may be linked to the genetic makeup of the patient in addition to external factors.

3 Jun 2020

Roscovitine enhances nuclear enrichment of traditionally cytoplasmic signaling molecules

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.

26 Mar 2020

A review of the literature on acute promyelocytic leukemia

Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem.

22 Mar 2020

Research shows link between clock genes and vitamin A pathway in the brain of Monarch butterflies

Biologists at Texas A&M University are making strides in understanding biological clock function in several model organisms and translating these studies into broader implications for human health.

6 Dec 2019

Research supports role of efficacy-first natural regimens to restore and improve skin health

Burt's Bees, a pioneer in natural skin care, today announced research supporting the role of efficacy-first natural regimens to defend, restore and improve skin health.

4 Oct 2019

New needle-free 'exosome' treatment to reduce wrinkles in UV-exposed mice

In the quest for a more youthful appearance, many people slather ointments on their skin or undergo injections of dermal fillers. But topical treatments often aren't very effective because they don't penetrate deep within the skin, whereas the results from injections typically last for only a few months and can be painful.

25 Sep 2019

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.