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New oral pill for COVID-19 home treatment

As cases and hospitalizations continue to rise in many countries, new treatments are being sought to arrest the progression of the disease, preventing severe illness and death or disability. One such is the small molecule molnupiravir, the focus of a new research paper.

20 Dec 2021

QTQTN motif upstream of furin-cleavage site in SARS-CoV-2 infection and pathogenesis

A new study posted to the bioRxiv* preprint server aimed to demonstrate whether the loss of the QTQTN motif attenuates SARS-CoV-2 replication in respiratory cells in vitro and pathogenesis in hamsters.

20 Dec 2021

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Researchers conduct a comprehensive in vitro analysis of relatively unexplored host immune responses during SARS-CoV-2 infection.

20 Dec 2021

Genomic study of furin cleavage sites validates the natural evolutionary origin of SARS-CoV-2 in bats

A team of researchers describes the genomic region encompassing the furin cleavage site in SARS-CoV-2.

20 Dec 2021

Efficacy of SARS-CoV2 variant-specific replicating RNA vaccines on SARS-CoV-2 variants of concern

A new study evaluates the repRNA vaccine expressing the SARS-CoV-2 spike protein for the B.1.1.7 and B.1.351 variants in mice and hamsters.

19 Dec 2021

Production of functional SARS-CoV-2 spike protein in single-cell green alga

A new study uses a novel algal platform for the generation of the SARS-CoV-2 spike protein.

19 Dec 2021

Study says COVID mRNA-based vaccines best for booster vaccination

A new study looks at the adaptive immune response to COVID-19 vaccines, wherein the authors compare heterologous to homologous immunization.

19 Dec 2021

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

A new study reports the results of a study focused on immune evasion characteristics, specifically the ability to escape neutralization by antibodies to the earlier SARS-CoV-2 variants or to the spike antigen used in COVID-19 vaccines.

16 Dec 2021

Evaluation of SARS-CoV-2 neutralizing antibodies in mothers and infants

A new study assessed nAb activities against five strains of SARS-CoV-2 in paired maternal and infant cord blood samples.

15 Dec 2021

How SARS-CoV-2 affects the male reproductive system

Researchers review the potentially harmful consequences on the male reproductive system in COVID-19 patients.

15 Dec 2021

Signatures of rising SARS-CoV-2 Delta infections in New York

Researchers estimate the probability of breakthrough infections by the Delta variant as compared to other variants.

15 Dec 2021

SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment

Researchers demonstrate that the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 require endogenous IFITM2 expression for efficient replication.

15 Dec 2021

Weak T-cell clonal response to SARS-CoV-2 vaccination in IBD patients deficient in antibody-responders

Researchers investigate the post-vaccination clonal T-cell response and its relationship to antibody responses in IBD patients.

15 Dec 2021

Exploring the impact of DNA nanoswitches in RNA purification

A new study reports a tool to enable RNA purification by sequence, helping to determine the structure, chemical modifications, and interactions between different RNA molecules.

15 Dec 2021

Omicron evades immunity more than other SARS-CoV-2 variants

Researchers find that the SARS-CoV-2 Omicron variant shows a much more extensive escape from vaccine-elicited immunity.

14 Dec 2021

Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

A recent study recently demonstrates the endosomal transport of nanoparticle-based formulations for the effective delivery of mRNA-based therapeutics.

14 Dec 2021

Vaccinated seropositive individuals are able to induce high anti-spike SIgA responses

Results of a new study show that the induction of anti-SARSCoV-2 spike saliva SIgA antibodies after vaccination is independent of the gender or type of vaccine received.

14 Dec 2021

Changes in trajectory of long COVID symptoms before vaccination

A new preprint describes the results of a study examining this aspect of the disease.

14 Dec 2021

Characteristics of vaccine breakthroughs in fully vaccinated individuals in France with delta variant

In a recent observational study, scientists have described the characteristics of VBIs in fully vaccinated individuals in France.

13 Dec 2021

Genetic-code expansion technique to potentially create next-generation vaccine candidate

A new experiment devised a novel method to manipulate virulent viruses in conventional laboratories and validated the prophylactic effect of this method in two mouse models.

13 Dec 2021

Ribonucleic Acid News and Research

New oral pill for COVID-19 home treatment

QTQTN motif upstream of furin-cleavage site in SARS-CoV-2 infection and pathogenesis

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Genomic study of furin cleavage sites validates the natural evolutionary origin of SARS-CoV-2 in bats

Efficacy of SARS-CoV2 variant-specific replicating RNA vaccines on SARS-CoV-2 variants of concern

Production of functional SARS-CoV-2 spike protein in single-cell green alga

Study says COVID mRNA-based vaccines best for booster vaccination

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

Evaluation of SARS-CoV-2 neutralizing antibodies in mothers and infants

How SARS-CoV-2 affects the male reproductive system

Signatures of rising SARS-CoV-2 Delta infections in New York

SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment

Weak T-cell clonal response to SARS-CoV-2 vaccination in IBD patients deficient in antibody-responders

Exploring the impact of DNA nanoswitches in RNA purification

Omicron evades immunity more than other SARS-CoV-2 variants

Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

Vaccinated seropositive individuals are able to induce high anti-spike SIgA responses

Changes in trajectory of long COVID symptoms before vaccination

Characteristics of vaccine breakthroughs in fully vaccinated individuals in France with delta variant

Genetic-code expansion technique to potentially create next-generation vaccine candidate

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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