Spike Protein News and Research

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South African SARS-CoV-2 variant escapes antibody neutralization

Researchers in South Africa have conducted a study showing that the novel 501Y.V2 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has emerged in the country is able to escape the neutralizing antibodies that are elicited by previously circulating strains of the virus.

20 Jan 2021

Researchers develop new method for charting SARS-CoV-2 spike protein glycosylation

Researchers develop a novel, simple and affordable method for N-glycan fingerprinting based on enzymatic fluorescent glycan labeling and electrophoresis. This new method may help us understand important changes in glycosylation in the SARS-CoV-2 spike protein – something which could inform future therapeutic research.

20 Jan 2021

Immune systems of COVID-19 patients may rely on antibodies from earlier coronaviruses

The results of a study led by Northern Arizona University and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest the immune systems of people infected with COVID-19 may rely on antibodies created during infections from earlier coronaviruses to help fight the disease.

20 Jan 2021

Over 100 million in India may have been infected by SARS-CoV-2

A large new study posted on the preprint server medRxiv describes the seropositivity rate to this virus, as well as the persistence of antibodies over time, both neutralizing and others.

19 Jan 2021

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

In an exciting, state-of-the-art study currently available on the medRxiv* preprint server, US researchers created a multi-coronavirus protein microarray containing full-length proteins, peptide libraries, and overlapping protein fragments from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as four other human coronaviruses.

19 Jan 2021

Memory B cell response to SARS-CoV-2 evolves up to 6 months after infection, study finds

A new study shows that the memory B cell response to SARS-Cov-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence.

19 Jan 2021

Study predicts good passive immunotherapy donors to combat COVID-19

A US-based research team determine good candidates for convalescent plasma donations in promoting passive immunity among severely-ill COVID-19 patients.

19 Jan 2021

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

A new study by US-based researchers describes the results of a study on the immune response among healthcare workers, in particular, their T cell responses predating the pandemic.

19 Jan 2021

N501Y mutation may be associated with higher viral load, says preliminary study

A new preprint research paper posted to the medRxiv server deals with the preliminary results of a study on the so-called British variant, UI-202012/01, also known as lineage B.1.1.7 or 20B/501Y.V1.

19 Jan 2021

About 60 percent of SARS-CoV-2 cases in England tied to new variant by the end of December

One new SARS-CoV-2 variant of concern, called 202012/01, started to spread in England in late October. A new study published on the pre-print server medRxiv found that 60 percent of daily COVID-19 cases screened by the Alderley Park Lighthouse Labs were tied to 202012/01, also known as lineage B.1.1.7 or 20B/501Y.V1. This suggests a rapid spread of the new variant across the country.

18 Jan 2021

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines

Now, researchers at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom, reveal that engineered closed S constructs may be valuable immunogens that can induce neutralizing antibodies against a different pattern of epitopes. This allows for the flexibility of vaccines at both the individual and population levels.

18 Jan 2021

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Researchers in China have conducted a study showing that a carbohydrate found in the seaweed Ecklonia kurome blocks the activity of an enzyme that is essential for the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

18 Jan 2021

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

A new study suggests that modified natural killer cells, which express a chimeric antigen receptor using S309 antibody, can bind to and inactivate SARS-CoV-2 spike protein in vitro.

18 Jan 2021

New SARS-CoV-2 variant emerges in the U.S.

Even as the rollout of vaccines all over the world brings a glimmer of hope that the current coronavirus disease 2019 (COVID-19) pandemic may end in the near future, new variants continue to emerge, some with the potential to escape vaccine-induced or therapeutic antibodies. Now, a new preprint research paper published on the bioRxiv server describes a new American variant that may have become the dominant strain in the USA.

18 Jan 2021

A high-temperature tolerant SARS-CoV-2 derived immunogen as a potential vaccine candidate

There have been significant efforts worldwide to combat COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One prominent strategy has been to develop vaccines against the virus. Numerous vaccine candidates are under development, and a handful have now been approved for use by several countries.

17 Jan 2021

National consortium to study the effects of emerging SARS-CoV-2 mutations

A new national research project to study the effects of emerging mutations in SARS-CoV-2 will be launched with £2.5 million of funding from UK Research and Innovation.

15 Jan 2021

Severe COVID-19 linked to genetic make-up of both host and virus, say researchers

A recent study conducted by a team of international scientists has revealed that the infectivity and pathogenicity of SARS-CoV-2 strongly depend on the genetic background of both the virus and the host.

15 Jan 2021

Image-based deep learning haplotype-guided study maps the global adaptation of SARS-CoV-2

A new study used deep learning with image recognition technology to trace the emergence of variants with increased viral fitness. Higher fitness leads to rapid expansion of these lineages in the areas where they are introduced. This type of study could facilitate the development of more effective antibodies and vaccines to help contain the pandemic.

15 Jan 2021

Concern develops over Brazilian SARS-CoV-2 variant

Concern is being expressed over a variant of SARS-CoV-2 that shows similar mutations to the South African and UK variants of the disease.

15 Jan 2021

New antiviral repurposing study finds peptides that could prevent SARS-CoV-2-ACE2 binding

A new study reports the antiviral potential of peptides against SARS-CoV-2's spike protein.

15 Jan 2021

Spike Protein News and Research

South African SARS-CoV-2 variant escapes antibody neutralization

Researchers develop new method for charting SARS-CoV-2 spike protein glycosylation

Immune systems of COVID-19 patients may rely on antibodies from earlier coronaviruses

Over 100 million in India may have been infected by SARS-CoV-2

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

Memory B cell response to SARS-CoV-2 evolves up to 6 months after infection, study finds

Study predicts good passive immunotherapy donors to combat COVID-19

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

N501Y mutation may be associated with higher viral load, says preliminary study

About 60 percent of SARS-CoV-2 cases in England tied to new variant by the end of December

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

New SARS-CoV-2 variant emerges in the U.S.

A high-temperature tolerant SARS-CoV-2 derived immunogen as a potential vaccine candidate

National consortium to study the effects of emerging SARS-CoV-2 mutations

Severe COVID-19 linked to genetic make-up of both host and virus, say researchers

Image-based deep learning haplotype-guided study maps the global adaptation of SARS-CoV-2

Concern develops over Brazilian SARS-CoV-2 variant

New antiviral repurposing study finds peptides that could prevent SARS-CoV-2-ACE2 binding

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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