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TACTIC project aims to uncover genetic causes of cancer and develop targeted therapies

Investigating the genetic causes of cancer and fighting them with new drugs: To this end, German Cancer Aid is funding the TACTIC project until 2028 with 11.8 million euros.

16 Nov 2023

Revolution by Evolution: Protein Science and its Impact on Drug Discovery

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Mark Abbott, the Managing Director of Peak Proteins, about protein science and its significance in drug discovery.

10 Nov 2023

Open-science drug discovery campaign yields a wealth of data on SARS-CoV-2 main protease

Although the group's work has been freely available since its inception in March 2020, the COVID Moonshot Consortium is finally formally reporting their results.

9 Nov 2023

COVID Moonshot Consortium makes major breakthrough in antiviral drug discovery

The work of the COVID Moonshot Consortium is being published in the prestigious journal Science on 10 November, revealing their discovery of a potent SARS-CoV-2 antiviral lead compound.

9 Nov 2023

Scientists determine structure of key protein in neuronal communication

Neurons talk to each other using chemical signals called neurotransmitters. Scientists at St. Jude Children's Research Hospital have drawn on structural biology expertise to determine structures of vesicular monoamine transporter 2 (VMAT2), a key component of neuronal communication.

2 Nov 2023

Highly sensitive blood test shows promise for early detection of common deadly cancers

Most cancers become deadly by keeping a low profile, causing no symptoms until they're too advanced to treat. Ovarian and gastroesophageal cancers are among the most notorious for this sly disease progression, often leading to late-stage diagnoses.

1 Nov 2023

Low-cost anti-inflammatory hydrogel could help treat chronic skin lesions in people with diabetes

Researchers in São Paulo state, Brazil, have developed a low-cost anti-inflammatory hydrogel that in future could help treat chronic skin lesions such as those often seen in people with diabetes.

27 Oct 2023

New consortium to build on breakthroughs in malaria research to develop P. vivax vaccines

Plasmodium vivax is the most widespread human malaria-causing pathogen with 2.5 billion people living at risk in Africa, South America, Oceania, and Asia.

24 Oct 2023

New discovery sheds light on how BRCA1 mutations cause cancer in women

Three decades after discoveries linking mutations in the BRCA1 gene to breast and ovarian cancer susceptibility, research led by Mays Cancer Center at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has pinpointed the molecular mechanism by which a large portion of these mutations cause cancers in women.

9 Oct 2023

Small and precise CRISPR-Cas13bt3 system can be used to shred viruses

Small and precise: These are the ideal characteristics for CRISPR systems, the Nobel-prize winning technology used to edit nucleic acids like RNA and DNA.

27 Sep 2023

Research opens up new directions to develop drugs for stopping cytokine storms

Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism's normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response.

14 Sep 2023

World-renowned Diamond Light Source facility to be upgraded through a £500 million investment

A groundbreaking science facility which kickstarted the UK's world leading Covid drug development and has advanced treatments of global health challenges from HIV to malaria and cancer will be upgraded and expanded through a more than £500 million investment, Science and Technology Secretary Michelle Donelan has announced today (Wednesday 6 September).

5 Sep 2023

Oncolytic viruses could be used to 'warm up' cold tumors and improve immunotherapy

Equipping cancer-infecting, or oncolytic, viruses with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy to shrink or completely clear aggressive tumors in mice, according to a new study in the Journal of Experimental Medicine led by University of Pittsburgh and UPMC researchers.

14 Aug 2023

Scientists uncover new molecular targets for cardiovascular regulation

Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses, have uncovered new molecular targets on a cell receptor that play a major role in cardiovascular regulation.

14 Aug 2023

Duke researchers develop potent antibiotic against drug-resistant superbugs

A scientific journey decades in the making at Duke University has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections (UTIs).

9 Aug 2023

New antibody shows promise in reversing carfentanil overdoses

An antibody in single-chain fragment variable (scFv) format that binds to the powerful opioid carfentanil was shown to reverse signs of carfentanil overdose in preclinical tests conducted by scientists at Scripps Research.

7 Aug 2023

Insilico Medicine uses AI to discover novel SIK2 inhibitors

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has achieved a significant breakthrough in the application of multiple generative AI models and AlphaFold structures for drug discovery.

2 Aug 2023

Mutational accessibility: A key driver of viral evolution

The influenza (flu) virus is constantly undergoing a process of evolution and adaptation through acquiring new mutations.

29 Jul 2023

Cryo-EM reveals structure of key enzyme involved in protein production

Transfer RNAs (tRNAs) are among the most common types of RNA in a cell and are indispensable for protein production in all known organisms.

13 Jul 2023

Histone acetyltransferases: Promising targets for cancer treatment

Announcing a new publication for Acta Materia Medica journal. Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage, a repairnd cell-cycle progression.

25 Jun 2023