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Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

As the world struggles to contain the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for over 1.6 million deaths and 76 million infections globally, researchers are trying to pin down the determinants of lethality, of infectivity and of protection. Such data would help contain its spread and develop preventive and therapeutic antivirals and vaccines. A new preprint that appeared recently on the bioRxiv* server describes the high degree of protection afforded by antibodies that target the N-terminal domain (NTD) of the virus.

24 Dec 2020

Immunologic modeling of COVID-19 severity and chronicity

In a new study by researchers at Universidad de Costa Rica and other institutions, a bioinformatics approach is used to determine whether Chronic COVID-19 (CC) might have a distinct immunologic signature compared to the mild to moderate (MM) or the severe/critical COVID-19.

24 Dec 2020

Loss of taste and smell may be most reliable COVID-19 symptoms for digital surveillance

A team of researchers from various institutions in London, Israel, and the USA recently tested the existence of consistent links between COVID-19 symptoms and SARS-CoV-2 test status in 3 national surveillance platforms.

24 Dec 2020

Mental disorders highly prevalent during coronavirus pandemics

Researchers in the United States have conducted an analysis showing the high prevalence of mental disorders across populations impacted by coronavirus pandemics.

24 Dec 2020

Researchers find correlation between consistent mask-wearing and improved well-being

A team of researchers at the University of Edinburgh, UK, suggest that consistent mask-wearing is associated with better wellbeing.

24 Dec 2020

Higher BMI linked to increased risk of SARS-CoV-2 infection

Researchers at the University of Miami Miller School of Medicine, USA, revealed that the spike-specific immunoglobulin G antibodies in obese people are negatively associated with body mass index (BMI) and serum levels of proinflammatory and metabolic markers of pulmonary inflammation.

24 Dec 2020

How has the COVID19 pandemic affected the well-being of pregnant women?

A new study by researchers at the Department of Women and Children’s Health at Uppsala University, Sweden, aimed to determine the effects of COVID-19 on pregnant women's mental health and well-being.

24 Dec 2020

A common compound in mouthwashes found to inhibit SARS-CoV-2 in vitro

Researchers found that cetylpyridinium chloride, found in most mouthwashes, lowers infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, likely by inhibiting viral fusion with target cells. With more tests to prove validity, mouthwashes could be a simple, cheap way of curbing transmission.

24 Dec 2020

Immersive VR can enhance the pain-relieving effectiveness of spinal cord stimulation

For patients receiving spinal cord stimulation (SCS) for chronic pain, integration with an immersive virtual reality (VR) system - allowing patients to see as well as feel the effects of electrical stimulation on a virtual image of their own body - can enhance the pain-relieving effectiveness of SCS, reports a study in PAIN, the official publication of the International Association for the Study of Pain.

23 Dec 2020

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

A recent computational study from India implicated a dysregulated vitamin D pathway in the pathobiology of the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and opened the door for experimental validation of these observations.

23 Dec 2020

Frequent and rapid testing may reduce SARS-CoV-2 transmission in carehomes

A team of scientists from the Centers for Disease Control and Prevention, United States, recently conducted a study to evaluate the effectiveness of serial testing and isolation of healthcare personnel in nursing homes in preventing the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19).

23 Dec 2020

Study finds treatment disparities for men and women with chest pain

The use of a standardized tool for assessing the risk of serious outcomes in patients with chest pain was associated with women at high risk receiving comparable care to men, according to new research published in the Annals of Emergency Medicine.

23 Dec 2020

Public adherence to COVID-19 guidelines in Norway: a case study

To evaluate and understand the adherence to public health actions recommended by the government, a team in Norway undertook a study funded in part by the Norwegian Research Council’s Centres of Excellence Funding Scheme and by the project: A realtime analytical pipeline for preparedness, planning, and response during the COVID-19 pandemic in Norway.

23 Dec 2020

SARS-CoV-2 mutations may evade T cell immunity

A potentially disturbing new study suggests that SARS-CoV-2 may be undergoing strategic mutations that affect the host immune capacity to recognize and combat the pathogen via T effector cells.

23 Dec 2020

Cell-mediated immunity may be more important than neutralizing antibodies in COVID-19 outcome

A new study sheds light on some important differences between asymptomatic and symptomatic patients with coronavirus disease 2019 (COVID-19).

23 Dec 2020

Researchers use fruit fly model to understand COVID-19-related neurological complications

Researchers claim to have reproduced disease mechanisms due to coronavirus disease 2019 (COVID-19) in the fruit fly, Drosophila, while also providing proof of the efficacy of one drug against these disease processes. If validated, these findings represent a new understanding of how the virus causes neurological symptoms that could help develop more effective therapies.

23 Dec 2020

New project to develop a platform for monitoring microvascular health of COVID-19 patients

VASCOVID, a new European project, will develop a platform that uses near-infrared light to monitor microvascular health of COVID-19 patients and assist clinicians in delivering customized treatments.

23 Dec 2020

Scientists discover molecular defects associated with rare genetic disorder in children

Damien D'Amours and his team at the Ottawa Institute of Systems Biology needed three years to discover the molecular defects associated with the LIC Syndrome, a serious genetic disorder that affects young children and result in acute respiratory distress, immune deficiency and abnormal chromosomes.

22 Dec 2020

FDA issues warning letters to companies illegally selling unapproved CBD products

Today, the U.S. Food and Drug Administration issued five warning letters to companies for selling products containing cannabidiol (CBD) in ways that violate the Federal Food, Drug, and Cosmetic Act (FD&C Act).

22 Dec 2020

SARS-CoV-2 antibody levels and types differ by disease severity, study finds

Researchers have measured the antibody levels and types in hospitalized coronavirus disease 2019 (COVID-19) patients with different disease severity. Their results suggest gut immune pathways could play a role in reducing virus-based inflammation and recovery.

22 Dec 2020

Syndrome News and Research

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

Immunologic modeling of COVID-19 severity and chronicity

Loss of taste and smell may be most reliable COVID-19 symptoms for digital surveillance

Mental disorders highly prevalent during coronavirus pandemics

Researchers find correlation between consistent mask-wearing and improved well-being

Higher BMI linked to increased risk of SARS-CoV-2 infection

How has the COVID19 pandemic affected the well-being of pregnant women?

A common compound in mouthwashes found to inhibit SARS-CoV-2 in vitro

Immersive VR can enhance the pain-relieving effectiveness of spinal cord stimulation

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

Frequent and rapid testing may reduce SARS-CoV-2 transmission in carehomes

Study finds treatment disparities for men and women with chest pain

Public adherence to COVID-19 guidelines in Norway: a case study

SARS-CoV-2 mutations may evade T cell immunity

Cell-mediated immunity may be more important than neutralizing antibodies in COVID-19 outcome

Researchers use fruit fly model to understand COVID-19-related neurological complications

New project to develop a platform for monitoring microvascular health of COVID-19 patients

Scientists discover molecular defects associated with rare genetic disorder in children

FDA issues warning letters to companies illegally selling unapproved CBD products

SARS-CoV-2 antibody levels and types differ by disease severity, study finds

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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