Telomerase News and Research

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Chemists develop promising molecular tool to target cell immortality's underlying gears

One of the hallmarks of cancer is cell immortality. A Northwestern University organic chemist and his team now have developed a promising molecular tool that targets and inhibits one of cell immortality's underlying gears: the enzyme telomerase.

3 Mar 2020

Observation of telomerase activity at a single-molecule level using 'optical tweezers'

Stem cells involved in replenishing human tissues and blood depend on an enzyme known as telomerase to continue working throughout our lives. When telomerase malfunctions, it can lead to both cancer and premature aging conditions.

3 Mar 2020

Rapamycin worsens diseases and premature aging in mice with short telomeres

In the past few decades, it was discovered that the rate at which we age is strongly influenced by biochemical processes that, at least in animal models, can be controlled in the laboratory.

3 Mar 2020

New insight into genomic alterations associated with telomere maintenance mechanisms in cancer

To gain an infinite lifespan, cancer cells need to maintain the ends of their chromosomes, known as telomeres. They achieve this in various different ways.

6 Feb 2020

New method uses MRI, machine learning to forecast genetic mutations in glioma tumors

Researchers at Osaka University have developed a computer method that uses magnetic resonance imaging (MRI) and machine learning to rapidly forecast genetic mutations in glioma tumors, which occur in the brain or spine. The work may help glioma patients to receive more suitable treatment faster, giving better outcomes.

9 Jan 2020

Researchers uncover novel molecular clues for tumor aggression in neurofibromatosis type 1

Researchers at the Johns Hopkins Kimmel Cancer Center report that their study of tumor samples from people with the rare genetic syndrome neurofibromatosis type 1 (NF1) has uncovered novel molecular clues about which tumors are most likely to be aggressive in those with NF1

From Johns Hopkins Medicine 18 Oct 2019

Scientists successfully create age-resistant mice with hyper-long telomeres

Researchers have shown that it is possible to extend the life of mice by generating hyper-long telomeres, without using any gene modifying technologies.

17 Oct 2019

Gene coding error likely responsible for rare form of inherited 'short telomere' disease

By combing through the entire genetic sequences of a person with a lung scarring disease and 13 of the person’s relatives, Johns Hopkins Medicine researchers say they have found a coding error in a single gene that is likely responsible for a rare form of the disease and the abnormally short protective DNA caps on chromosomes long associated with it.

From Johns Hopkins Medicine 11 Sep 2019

Study reshapes the understanding of telomerase's function in normal cells

New research from the University of Maryland and the National Institutes of Health reveals a new role for the enzyme telomerase.

3 Sep 2019

DNA methylation closely linked to telomere length

Aging is associated with multiple disease conditions. Recently it has been found that many of these illnesses are linked to the length of the telomeres at the ends of every chromosome. Telomere length (TL) is affected by both genetic and epigenetic contributions.

2 Sep 2019

Protein present in telomeres shows global action on genome which influences pleuripotency

Pluripotent cells can give rise to all cells of the body, a power that researchers are eager to control because it opens the door to regenerative medicine and organ culture for transplants.

21 Aug 2019

Researcher finds possible strategy for killing cancer cells in children

In Belgium, there are 70,000 new adult cases of cancer every year, compared to 350 in children. Owing to lack of interest from pharmaceutical groups, treatments for pediatric cancers are developing much less rapidly than those for adults.

4 Jul 2019

Researchers identify effective drug combinations for malignant brain tumor in mice

Usually, scientists study the molecular biology of cancer to find new treatments, but sometimes, it is the other way round: when trying to find new treatments, scientists find key information on cancer biology.

14 Jun 2019

Unsupportive parenting may have negative health implications for children, study suggests

New research out of Loma Linda University Health suggests that unsupportive parenting styles may have several negative health implications for children, even into their adult years.

30 May 2019

Researchers discover unexpected survival mechanism of a subset of cancer cells

Embedded at the end of chromosomes are structures called "telomeres" that in normal cells become shorter as cells divide. As the shortening progresses it triggers cell proliferation arrest or death. Cancer cells adopt different strategies to overcome this control mechanism that keeps track of the number of times that a cell has divided.

28 May 2019

Oxidative stress acts directly on telomeres to hasten cellular aging, study reveals

The same sources thought to inflict oxidative stress on cells- pollution, diesel exhaust, smoking and obesity- also are associated with shorter telomeres, the protective tips on the ends of the chromosomal shoelace.

14 May 2019

Biological aging caused by cancer treatments correlates with cognitive decline

Cancer treatments are suspected to accelerate certain aging processes in the body. A new study has found that indicators of such biological aging correlate with declines in cognitive function in women who had undergone breast cancer treatment several years earlier.

26 Nov 2018

First bifacial molecule can invade double-stranded DNA or RNA

Carnegie Mellon University researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a new platform for developing methods for the diagnosis and treatment of genetic conditions.

13 Nov 2018

Meditation, music may change biomarkers of cellular aging and Alzheimer’s disease in older adults

A research team led by Dr. Kim Innes, a professor in the West Virginia University School of Public Health, has found that a simple meditation or music listening program may alter certain biomarkers of cellular aging and Alzheimer's Disease in older adults who are experiencing memory loss.

13 Nov 2018

New way of identifying potential cancer drugs could streamline development of therapies

A new way of identifying potential cancer drugs could streamline the development of therapies, following a discovery by scientists.

2 Nov 2018

Telomerase News and Research

Chemists develop promising molecular tool to target cell immortality's underlying gears

Observation of telomerase activity at a single-molecule level using 'optical tweezers'

Rapamycin worsens diseases and premature aging in mice with short telomeres

New insight into genomic alterations associated with telomere maintenance mechanisms in cancer

New method uses MRI, machine learning to forecast genetic mutations in glioma tumors

Researchers uncover novel molecular clues for tumor aggression in neurofibromatosis type 1

Scientists successfully create age-resistant mice with hyper-long telomeres

Gene coding error likely responsible for rare form of inherited 'short telomere' disease

Study reshapes the understanding of telomerase's function in normal cells

DNA methylation closely linked to telomere length

Protein present in telomeres shows global action on genome which influences pleuripotency

Researcher finds possible strategy for killing cancer cells in children

Researchers identify effective drug combinations for malignant brain tumor in mice

Unsupportive parenting may have negative health implications for children, study suggests

Researchers discover unexpected survival mechanism of a subset of cancer cells

Oxidative stress acts directly on telomeres to hasten cellular aging, study reveals

Biological aging caused by cancer treatments correlates with cognitive decline

First bifacial molecule can invade double-stranded DNA or RNA

Meditation, music may change biomarkers of cellular aging and Alzheimer’s disease in older adults

New way of identifying potential cancer drugs could streamline development of therapies

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