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Study establishes the ideal immunosuppression regimen for pig-to-human kidney xenotransplantation

Currently used Food and Drug Administration-approved transplant drugs -; with the addition of an also already FDA-approved complement inhibitor -; are the optimal immunosuppression regimen for pig-to-human kidney transplants, according to a landmark discovery by University of Alabama at Birmingham investigators.

25 Jan 2024

Mount Sinai project receives $4M grant to understand the early stages of Crohn's disease

The Icahn School of Medicine at Mount Sinai has been awarded a grant of more than $4 million from The Leona M. and Harry B. Helmsley Charitable Trust to support an innovative research project aimed at understanding the early stages of Crohn's disease before noticeable symptoms develop.

25 Jan 2024

Study shows effectiveness of gene therapy in treating congenital deafness

A new study co-led by investigators from Mass Eye and Ear, a member of Mass General Brigham, demonstrated the effectiveness of a gene therapy towards restoring hearing function for children suffering from hereditary deafness.

24 Jan 2024

Balancing efficacy and safety: The challenges of mRNA drugs and vaccines in modern medicine

Researchers analyzed the toxicity concerns and advancements in mRNA therapeutics, focusing on their cellular toxicity, reactogenicity, and distribution, and discussed the challenges and benefits of mRNA research.

24 Jan 2024

Genomics meets retinal imaging: A powerful fusion can predict future health

The retina is said to provide a window into a person's systemic health. In a new study published January 24th in Science Translational Medicine, physician-researchers from Mass Eye and Ear, a member of Mass General Brigham, and the Broad Institute of MIT and Harvard combined retinal imaging, genetics and big data to estimate how likely a person is to develop eye and systemic diseases in the future.

24 Jan 2024

UKHSA unveils groundbreaking Pathogen Genomics Strategy for pandemic preparedness

The UK Health Security Agency (UKHSA) has today published its Pathogen Genomics Strategy, laying out a 5 year plan for the organization's role in the wider delivery of pathogen genomics to prepare for and respond to infectious disease threats to public health.

24 Jan 2024

Turning senescent tumor cells into targets for better cancer treatment

Cancer treatments, including chemotherapy, in addition to killing a large number of tumor cells, also result in the generation of senescent tumor cells (also called "zombi cells").

24 Jan 2024

Study shows how CBT rewires the anxious child's brain

Researchers at the National Institutes of Health have found overactivation in many brain regions, including the frontal and parietal lobes and the amygdala, in unmedicated children with anxiety disorders.

24 Jan 2024

Calluna Pharma launches and announces EUR 75 million Series A financing to develop novel therapies for inflammatory and fibrotic diseases

Oxitope Pharma (Oxitope) and Arxx Therapeutics (Arxx), companies with a shared goal of leveraging the innate immune system to discover and develop disease modulating therapies, today announced their merger to form Calluna Pharma Inc. (Calluna).

From Calluna Pharma 24 Jan 2024

C-Path's TRxA launches 2024 grants to boost next-gen therapeutics

Critical Path Institute's (C-Path) Translational Therapeutics Accelerator (TRxA) today announced its 2024 global Request for Proposals for its Breakthrough Research and Innovation in Drug Development Grants, also known as BRIDGe.

23 Jan 2024

Study finds patients with long COVID exhibit complement dysregulation with signs of thromboinflammation

Researchers explore inflammatory signatures restricted to patients with active post-acute COVID-19 sequelae.

23 Jan 2024

NHS Health Check linked to lower disease rates and mortality, study shows

Attending an NHS Health Check appointment -; a preventative screening programme offered for free in the UK -; is associated with both a decreased risk of dying and a decreased risk of several diseases, including dementia and liver cirrhosis.

22 Jan 2024

Revolutionary bio-sponge halts bleeding instantly

More than 11 million people in the United States take anticoagulation or antiplatelet medications, such as heparin or aspirin, to treat serious conditions like heart attack and stroke.

22 Jan 2024

Thinning brain tissue predicts dementia up to a decade before symptoms

A ribbon of brain tissue called cortical gray matter grows thinner in people who go on to develop dementia, and this appears to be an accurate biomarker of the disease five to 10 years before symptoms appear, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported.

22 Jan 2024

Scientists demonstrate way to produce SARS-CoV-2 receptor protein in mouse cells

A team of scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and Columbia University has demonstrated a way to produce large quantities of the receptor that SARS-CoV-2, the virus that causes COVID-19, binds to on the surface of human cells.

22 Jan 2024

Immune checkpoint inhibitor target found to promote skin cancer growth

Programmed cell death 1 (PD-1) is an important target for immune checkpoint inhibitor therapies that block its signaling and boost T-cell activity. PD-1 inhibitors have been approved for treating various types of cancer.

19 Jan 2024

CRISPR off-switch discovered: Safer gene editing for future therapies

Using CRISPR, an immune system bacteria use to protect themselves from viruses, scientists have harnessed the power to edit genetic information within cells.

19 Jan 2024

Biodesign needs open-ended systems for future innovation

Scientists working on biological design should focus on the idiosyncrasies of biological systems over optimization, according to new research.

19 Jan 2024

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024

Study analyzes the use of tissue-agnostic therapeutics in patients with primary brain tumors

Researchers from Miami Cancer Institute, part of Baptist Health South Florida, today published a study in Trends in Cancer that analyzes the use of tissue-agnostic therapeutics in patients with primary brain tumors (PBTs).

19 Jan 2024

Therapeutics News and Research

Study establishes the ideal immunosuppression regimen for pig-to-human kidney xenotransplantation

Mount Sinai project receives $4M grant to understand the early stages of Crohn's disease

Study shows effectiveness of gene therapy in treating congenital deafness

Balancing efficacy and safety: The challenges of mRNA drugs and vaccines in modern medicine

Genomics meets retinal imaging: A powerful fusion can predict future health

UKHSA unveils groundbreaking Pathogen Genomics Strategy for pandemic preparedness

Turning senescent tumor cells into targets for better cancer treatment

Study shows how CBT rewires the anxious child's brain

Calluna Pharma launches and announces EUR 75 million Series A financing to develop novel therapies for inflammatory and fibrotic diseases

C-Path's TRxA launches 2024 grants to boost next-gen therapeutics

Study finds patients with long COVID exhibit complement dysregulation with signs of thromboinflammation

NHS Health Check linked to lower disease rates and mortality, study shows

Revolutionary bio-sponge halts bleeding instantly

Thinning brain tissue predicts dementia up to a decade before symptoms

Scientists demonstrate way to produce SARS-CoV-2 receptor protein in mouse cells

Immune checkpoint inhibitor target found to promote skin cancer growth

CRISPR off-switch discovered: Safer gene editing for future therapies

Biodesign needs open-ended systems for future innovation

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Study analyzes the use of tissue-agnostic therapeutics in patients with primary brain tumors

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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