Therapeutics News and Research

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Ranbaxy and GlaxoSmithKline form alliance

Ranbaxy Laboratories announced today that the Company and GlaxoSmithKline have signed a new, multiyear R&D agreement that modifies and expands the terms of their strategic alliance established in 2003 to provide Ranbaxy expanded drug-development responsibilities and further financial opportunities.

6 Feb 2007

RNA used to turn on genes to alleviate disease

A new technique that employs RNA, a tiny chemical cousin of DNA, to turn on genes could lead to therapeutics for conditions in which nudging a gene awake would help alleviate disease, researchers at UT Southwestern Medical Center say.

28 Jan 2007

Manipulation of proliferation and differentiation of human bone marrow derived neural stem cells in vitro and in vivo

Stem cells taken from adult human bone marrow have been manipulated by scientists at the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center to generate aggregates of cells called spheres that are similar to those derived from neural stem cells of the brain.

28 Jan 2007

Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging

Iron oxide nanoparticles have shown promise as agents for detecting tumors using magnetic resonance imaging (MRI), but such efforts have been limited by the relatively weak magnetic signal generated by these nanoparticles.

22 Jan 2007

Nanoparticles yield delivery tools for therapeutic nucleic acids

Cancer researchers hold great hope that nucleic acid-based therapeutics, such as anticancer genes, antisense oligonucleotides, and small interfering RNA (siRNA) molecules, will prove to be powerful antitumor agents.

16 Jan 2007

EDMA welcomes 7 new members

EDMA, the European Diagnostic Manufacturers Association, enlarges its membership with six new companies: BioSystems SA, Diagnostica Stago, Innogenetics, Luminex Corporation, Orion Diagnostica and Tecan, and the Foundation for Innovative New Diagnostics (FIND).

9 Jan 2007

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme

Glioblastoma multiforme is among the most aggressive and difficult cancers to treat. Now, researchers at Penn State University have shown that a lipid-based nanoparticle, designed to bind to a specific receptor found on malignant brain cells but not healthy ones, improves the potency of a common anticancer drug and slows significantly the growth of glioblastoma in mice.

8 Jan 2007

Sigma-Aldrich grants Pfizer license to use ddRNAi

Sigma-Aldrich has announced that it has granted Pfizer a worldwide non-exclusive research license to utilize DNA-directed RNAi (ddRNAi) technology. Applications of the ddRNAi technology for research activities have been licensed exclusively by Sigma- Aldrich from Benitec Limited of Australia.

3 Jan 2007

Epidurals affect how successful breastfeeding will be

According to researchers in Australia having an epidural to relieve labour pains may affect how successful breastfeeding will be.

12 Dec 2006

Scientists discover how androgen plays a role in the development of prostate cancer

Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.

8 Nov 2006

Squalenoyl nanomedicines as potential therapeutics

Nucleoside analogs such as cytarabine and gemcitabine are powerful anticancer agents, but a simple chemical modification that causes them to assemble into stable nanoparticles could make them even more valuable in the treatment of a wide variety of cancers.

23 Oct 2006

CCR5 receptor discovery could help fight against tuberculosis, HIV

A key aspect of how the body kicks the immune system into action against tuberculosis is revealed in research published today.

20 Oct 2006

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

Efforts to treat cancer using genes and other oligonucleotides, such as short interfering RNA (siRNA), that turn off the biochemical processes that trigger malignancies have been hindered by difficulties in delivering nucleic acids to tumors.

16 Oct 2006

p120 catenin protein can stop metastasis or promote it

A protein known to be a key component of the glue that holds cells together also is involved in breaking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found.

20 Sep 2006

Fewer than half of studies conducted on effect of medications on children are published

Fewer than half of studies conducted on the effects of prescription drugs in children are published in medical journals, according to a study published Wednesday in the Journal of the American Medical Association, the AP/Lexington Herald-Leader reports.

14 Sep 2006

Therapeutics News and Research

Ranbaxy and GlaxoSmithKline form alliance

RNA used to turn on genes to alleviate disease

Manipulation of proliferation and differentiation of human bone marrow derived neural stem cells in vitro and in vivo

Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging

Nanoparticles yield delivery tools for therapeutic nucleic acids

EDMA welcomes 7 new members

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme

Sigma-Aldrich grants Pfizer license to use ddRNAi

Epidurals affect how successful breastfeeding will be

Scientists discover how androgen plays a role in the development of prostate cancer

Squalenoyl nanomedicines as potential therapeutics

CCR5 receptor discovery could help fight against tuberculosis, HIV

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

p120 catenin protein can stop metastasis or promote it

Fewer than half of studies conducted on effect of medications on children are published

NIH to map genomic changes of lung, brain, and ovarian cancers

Studies on effects of drugs on children often not published

New class of super NSAIDs

ExonHit licenses Merck rights to RNA splicing microarray patent

SemBioSys Genetics granted immunoglobulin related patent

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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