Therapeutics News and Research

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Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

Efforts to treat cancer using genes and other oligonucleotides, such as short interfering RNA (siRNA), that turn off the biochemical processes that trigger malignancies have been hindered by difficulties in delivering nucleic acids to tumors.

16 Oct 2006

p120 catenin protein can stop metastasis or promote it

A protein known to be a key component of the glue that holds cells together also is involved in breaking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found.

20 Sep 2006

Fewer than half of studies conducted on effect of medications on children are published

Fewer than half of studies conducted on the effects of prescription drugs in children are published in medical journals, according to a study published Wednesday in the Journal of the American Medical Association, the AP/Lexington Herald-Leader reports.

14 Sep 2006

NIH to map genomic changes of lung, brain, and ovarian cancers

It is estimated that 174,470 new cases of lung cancer will be diagnosed in the United States in 2006. Lung cancer is the major cause of cancer-related mortality in both men and women, with an estimated 162,460 deaths expected to occur in 2006.

13 Sep 2006

Studies on effects of drugs on children often not published

According to a new study by researchers at Duke University Medical Center, many of the drugs that are prescribed for children may not in fact be either safe or effective for pediatric use and could require different doses than is recommended.

13 Sep 2006

New class of super NSAIDs

Building on previous work, researchers at the University of Pennsylvania School of Medicine have found that deleting an inflammation enzyme in a mouse model of heart disease slowed the development of atherosclerosis.

12 Sep 2006

ExonHit licenses Merck rights to RNA splicing microarray patent

ExonHit Therapeutics S.A., a drug and diagnostic discovery company, has announced that Merck & Co., Inc. has been granted a non-exclusive license to rights for research only under Patent US 6,881,571.

11 Sep 2006

SemBioSys Genetics granted immunoglobulin related patent

SemBioSys Genetics has announced it has been granted U.S. patent 7,098,383 entitled "Methods for the production of multimeric immunoglobulins, and related compositions".

11 Sep 2006

New map for human genome expression

ExonHit Therapeutics has announced the completion of a new messenger RNA (transcripts) map coming from human genome expression.

5 Sep 2006

Cancer Research Technology announce colorectal cancer research collaboration with AstraZeneca

Cancer Research Technology (CRT), the oncology-focused development and commercialisation company wholly owned by Cancer Research UK, today announce that they have entered into an agreement with AstraZeneca focused on colorectal cancer.

4 Sep 2006

Researchers identify how molecules of microRNA are responsible for the growth of blood vessels in a model for human colon cancer

The process, called angiogenesis, results in ability of ravenous cancer cells to recruit blood vessels and receive a steady supply of nutrients and oxygen.

4 Aug 2006

BRIT1 gene plays a pivotal role in DNA damage detection and repair

A single gene plays a pivotal role launching two DNA damage detection and repair pathways in the human genome, suggesting that it functions as a previously unidentified tumor suppressor gene.

3 Aug 2006

Better understanding of intravenous immunoglobulin

For years, researchers have struggled to understand how IVIG worked. It's ability to treat autoimmune diseases seemed to bean apparent contradiction.

3 Aug 2006

New therapeutics for cancer

A team of scientists at the University of Liverpool has secured the services of the National Biomanufacturing Centre (NBC) to develop and manufacture antibodies against a novel cancer antigen.

1 Aug 2006

HHS to stockpile Anthrax immune globulin

The Department of Health and Human Services (HHS) has announced it will purchase 10,000 therapeutic courses of treatment of Anthrax Immune Globulin (AIG) from Cangene Corporation of Winnipeg, Manitoba, Canada for a total of $143,833,719.

30 Jul 2006

Scientists characterize structure of calbindin-D28K

Scientists at North Carolina State University have effectively lifted the veil from an important protein that is linked to the prevention of neurodegenerative diseases like Alzheimer's and Huntington's.

26 Jul 2006

Cigarette smoking appears to promote the consumption of alcohol

Nicotine can reduce blood alcohol concentrations (BACs) at dosage levels that could be achieved by human smokers.

25 Jul 2006

3D model reveals secrets of metastasis

A cancer cell breaks away from a primary tumor and settles in a new location, where it once again divides.

12 Jul 2006

First trial to investigate effects of cannabinoids on progression of multiple sclerosis

Clinicians from across the UK have now embarked on the world's first trial to investigate whether cannabis derivatives could play a role in slowing the progression of multiple sclerosis.

11 Jul 2006

Scientists discover promising new therapeutic target for heart disease

Scientists at the Boston Biomedical Research Institute identified Puma (p53 upregulated modulator of apoptosis) as a potential new target for the therapeutic intervention of heart disease.

10 Jul 2006