Titration News and Research

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Study reveals safety, efficacy of brexpiprazole for schizophrenia patients with severe psychotic symptoms

Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S announced study results on the safety and efficacy of brexpiprazole in the treatment of patients with schizophrenia experiencing severe psychotic symptoms during an acute episode. The data will be presented at the upcoming Psych Congress, held in Orlando from October 25-28, 2018.

26 Oct 2018

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Merck, known as MSD outside the United States and Canada, today announced the first presentation of preliminary data from a Phase 1 clinical trial evaluating MK-1454, an investigational STING (stimulator of interferon genes) agonist, as monotherapy and in combination with KEYTRUDA (pembrolizumab), Merck's anti-PD-1 therapy, in patients with advanced solid tumors or lymphomas.

22 Oct 2018

New Metrohm IC method is reliable and convenient to use for zinc oxide assay

USP has updated the General Chapter <591> «Zinc Determination» monograph to include ion chromatography as the preferred method for measuring zinc oxide assay.

From Metrohm USA Inc. 17 Oct 2018

Determining acid-neutralizing capacity for OTC antacids

USP<301> describes a back-titration to determine the acid-neutralizing capacity (ANC).

From Metrohm USA Inc. 17 Oct 2018

Biogen and Eisai announce results of LTE Phase 1b study of aducanumab for treating MCI

Biogen and Eisai Co., Ltd. announced results from a recent analysis of the ongoing long-term extension Phase 1b study of aducanumab, an investigational treatment for mild cognitive impairment due to Alzheimer's disease and mild AD dementia.

24 Sep 2018

$CHMP grants positive opinion for VENCLYXTO plus rituximab for treating relapsed/refractory CLL$

CHMP grants positive opinion for VENCLYXTO plus rituximab for treating relapsed/refractory CLL

AbbVie, a research-based global biopharmaceutical company, announced today that the Committee for Medicinal Products for Human Use of the European Medicines Agency has granted a positive opinion for VENCLYXTO® in combination with rituximab for the treatment of patients with relapsed/refractory chronic lymphocytic leukemia who have received at least one prior therapy.

21 Sep 2018

Mechanical properties of viral DNA influence the course of infection, study finds

A new study reveals a previously unknown mechanism that governs whether viruses that infect bacteria will quickly kill their hosts or remain latent inside the cell. The discovery, reported in the journal eLife, also may apply to viruses that infect humans and other animals, the researcher said.

5 Sep 2018

USPTO awards two more patent allowances to Glytec for its insulin optimization system

The United States Patent and Trademark Office has awarded Glytec two more patent allowances acknowledging the unique characteristics of its disruptive innovations.

29 Aug 2018

$Entresto drug can be initiated early and safely in heart failure patients with reduced ejection fraction$

Entresto drug can be initiated early and safely in heart failure patients with reduced ejection fraction

Data from the TRANSITION study presented today at the European Society of Cardiology Congress in Munich, Germany has shown that Entresto® can be initiated early and safely in a wide range of heart failure patients with reduced ejection fraction who have been stabilized after hospitalization due to an acute heart failure episode.

25 Aug 2018

Glooko to demonstrate new version of diabetes management mobile application at ADA meeting

Glooko, the leader in diabetes data management, today announced participation in the 78th Annual American Diabetes Association meeting taking place this weekend in Orlando, Fla.

22 Jun 2018

FDA approves novel enzyme therapy for adults with rare and serious genetic disease

The U.S. Food and Drug Administration today approved Palynziq (pegvaliase-pqpz) for adults with a rare and serious genetic disease known as phenylketonuria (PKU).

25 May 2018

Study links cell size with commitment to division

How does a cell know when to divide? We know that hundreds of genes contribute to a wave of activity linked to cell division, but to generate that wave new research shows that cells must first grow large enough to produce four key proteins in adequate amounts.

24 May 2018

OMNIS offers safe, easy way to perform volumetric Karl Fischer titrations

Metrohm expands the OMNIS Titration Platform enabling users to perform volumetric Karl Fischer titrations.

From Metrohm USA Inc. 7 May 2018

OMNIS Sample Robot offers reliable automation for serial volumetric Karl Fischer titration

Automating volumetric titration in whole series of samples used to be a challenge: Firstly, risk of ambient moisture compromising sample integrity.

From Metrohm USA Inc. 7 May 2018

Metrohm’s complete know-how on pharmaceutical analysis

No other industry is as thoroughly regulated as the pharmaceutical industry. The active ingredients are legion and so are the standards to test for them.

From Metrohm USA Inc. 7 May 2018

TradeShow Talks with Metrohm

Metrohm is the market leader for ion analysis. Analytica is the most important trade show for us on a global scale.

From Metrohm USA Inc. 13 Apr 2018

Transformative new approach for viral titer determination using xCELLigence RTCA

Accurate determination of viral titers is critical to vaccine development. Historically, titers have been determined using endpoint assays which are labor-intensive, expensive, and time-consuming. This is increasingly problematic in modern production facilities where bioprocess optimization is performed using high-throughput cell culture reactors that can produce batches of virus faster than they can be analyzed.

13 Mar 2018

McGill scientists invent new technique for measuring enzyme inhibition

Researchers at McGill University have invented a new technique for measuring how quickly drugs interact with their molecular targets. The discovery provides scientists with a new way to investigate the effectiveness of drug candidates that might otherwise have been overlooked.

2 Mar 2018

Metrohm presents accurate method for determination of metal-organic compounds by thermometric titration

Metrohm is pleased to present a fast and highly accurate method for the determination of metal-organic compounds by thermometric titration.

From Metrohm USA Inc. 1 Feb 2018

Taking sleep medications to treat insomnia may increase risk of falling for older adults

Taking physician-recommended sleep medications to treat insomnia may actually increase the risk of falling for older adults, according to a team of sleep researchers.

10 Oct 2017

Titration News and Research

Study reveals safety, efficacy of brexpiprazole for schizophrenia patients with severe psychotic symptoms

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

New Metrohm IC method is reliable and convenient to use for zinc oxide assay

Determining acid-neutralizing capacity for OTC antacids

Biogen and Eisai announce results of LTE Phase 1b study of aducanumab for treating MCI

CHMP grants positive opinion for VENCLYXTO plus rituximab for treating relapsed/refractory CLL

Mechanical properties of viral DNA influence the course of infection, study finds

USPTO awards two more patent allowances to Glytec for its insulin optimization system

Entresto drug can be initiated early and safely in heart failure patients with reduced ejection fraction

Glooko to demonstrate new version of diabetes management mobile application at ADA meeting

FDA approves novel enzyme therapy for adults with rare and serious genetic disease

Study links cell size with commitment to division

OMNIS offers safe, easy way to perform volumetric Karl Fischer titrations

OMNIS Sample Robot offers reliable automation for serial volumetric Karl Fischer titration

Metrohm’s complete know-how on pharmaceutical analysis

TradeShow Talks with Metrohm

Transformative new approach for viral titer determination using xCELLigence RTCA

McGill scientists invent new technique for measuring enzyme inhibition

Metrohm presents accurate method for determination of metal-organic compounds by thermometric titration

Taking sleep medications to treat insomnia may increase risk of falling for older adults

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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