Determining acid-neutralizing capacity for OTC antacids

USP<301> describes a back-titration to determine the acid-neutralizing capacity (ANC). The method is very fast, easy, and reliable. The Metrohm Application Note AN T-192 includes the effective determination of ANC for scores of over-the-counter (OTC) antacids. The titration procedure works for samples such as magaldrate and simethicone for oral suspension and alumina, magnesia and simethicone in the form of chewing gums as well as for 36 further samples.

Antacids neutralize stomach acidity to relieve heartburn, sour stomach, acid indigestion, and stomach upset. They are also used to relieve the pain of stomach and duodenal ulcers. Antacids are formulated from materials such as alumina, magaldrate, magnesia, simethicone, calcium carbonate and dihydroxyaluminum. They are packaged as liquids, gels, tablets, powders, granules, and even as chewing-gums.

Metrohm offers ANC Application

Using titration to a set endpoint of pH 3.5 the Metrohm Application Note shows the determination of the acid-neutralizing capacity for alumina magnesia, simethicone chewable tablet, magaldrate and simethicone oral suspension, and for 36 further samples. It is documented in the Application Note AN T-192, which can be downloaded from the Metrohm website.

Heartburn – one of the most common chronic diseases

Acid indigestion and heartburn are widespread. Each year, people spend billions of dollars globally on antacids in search of relief. According to a Surgery of World Journal Gastrointest in 2016 it is estimated that up to 20 till 25 percent of Americans experience symptoms of prevalence of gastroesophageal reflux disease (GERD) weekly.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Metrohm AG. (2019, June 24). Determining acid-neutralizing capacity for OTC antacids. News-Medical. Retrieved on October 25, 2020 from

  • MLA

    Metrohm AG. "Determining acid-neutralizing capacity for OTC antacids". News-Medical. 25 October 2020. <>.

  • Chicago

    Metrohm AG. "Determining acid-neutralizing capacity for OTC antacids". News-Medical. (accessed October 25, 2020).

  • Harvard

    Metrohm AG. 2019. Determining acid-neutralizing capacity for OTC antacids. News-Medical, viewed 25 October 2020,


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
You might also like... ×
Science, cheese and mountains, in Switzerland the winners of the Metrohm Young Chemist Award Announced