Biochemistry

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Metabolic rewiring could help CAR-T cells fight solid tumors

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells inside solid tumors. It highlights metabolic reprogramming as a promising strategy to improve CAR-T cell persistence, adaptability, and anti-tumor function.

29 Apr 2026

Study provides roadmap for safer pharmaceutical analysis methods

A new doctoral thesis at Karlstad University provides increased understanding of how medicines can be analysed more reliably and safely.

28 Apr 2026

UBC researchers develop new way to target previously undruggable proteins

Researchers at the University of British Columbia and BC Cancer have developed a new way to target proteins long considered "undruggable," opening the door to new treatments for prostate cancer and other serious diseases.

28 Apr 2026

Scientists uncover why brain damage continues after stroke

Every stroke begins with a sudden interruption of blood flow in the brain. But what happens afterward—why neurons continue to lose function and die over the following days—has remained one of the most important unanswered questions in neuroscience.

28 Apr 2026

A new biological switch to slow atherosclerosis progression

A study by researchers at Baylor College of Medicine and collaborating institutions reveals a previously unrecognized way blood vessels can protect themselves from damage and slow the development of atherosclerosis. The findings, published in the Proceedings of the National Academy of Sciences, have implications for both vascular precision medicine and the safety of certain emerging cancer treatments.

28 Apr 2026

Decoy strategy boosts natural bacteria to clean polluted soils

Aromatic compounds, such as dioxins and benzene, are major soil pollutants. Their high chemical stability makes them resistant to microbial and chemical degradation, leading to toxic accumulation in the soil.

11 Apr 2026

New technique finds bacteria to increase the vitamin B2 content of soya drinks

Researchers at DTU have developed a new method that can reduce the time needed to find new bacteria for fermentation.

10 Apr 2026

Korean skincare ingredient emerges as potential antibiotic candidate

Fans of Korean skincare may be familiar with 'hero ingredient' Madecassic acid for its skin-soothing properties, but researchers at the University of Kent have revealed its greater potential for use in the battle against antibiotic resistance.

9 Apr 2026

Novel catalytic approach accelerates synthesis of branched drug compounds

When chemists design drug candidates, shape matters enormously. Many active pharmaceutical ingredients contain branched carbon structures-points where the molecular chain forks in a specific direction-that are critical to whether a molecule will bind to its biological target and whether it will be safe.

9 Apr 2026

Study reveals how bacterial collagenase efficiently breaks down collagen

Collagen is an important protein that helps build the tissues of humans and animals. It is very strong because it is made of three protein strands twisted tightly together like a rope. Because of this sturdy structure, ordinary protein-cutting enzymes usually cannot break it down.

3 Apr 2026

New drying technique stabilizes vital vaccines at room temperature

A significant challenge in global healthcare and biotechnology is the "cold chain"-the network of refrigerated storage and transport required to keep protein-based drugs, vaccines, and diagnostic tests from degrading.

2 Apr 2026

Viruses eavesdrop on signals but risk making harmful decisions

Viruses can "eavesdrop" on each other using chemical signals – but it can backfire for the eavesdropper, new research shows.

31 Mar 2026

New models predict biological age using blood and microbiome

A new research paper was published in Volume 18 of Aging-US on March 12, 2026, titled "Blood biochemical and gut microbiotic neural network models forecasting human biological age."

23 Mar 2026

Scientists reveal how light-activated drugs change receptor activity

Rendering a drug effective or ineffective in a flash at the appropriate location – this is the focus of research in photopharmacology.

19 Mar 2026

Dragon fruit peel extract enhances bread nutrition and reduces food waste

A research team led by Professor ZHOU Weibiao from the Department of Food Science and Technology at the NUS Faculty of Science has shown that compounds extracted from red dragon fruit peel can be incorporated into bread to increase antioxidant activity and slow starch digestion, offering a potential pathway to healthier staple foods and reduced food waste.

17 Mar 2026

Study reveals dual role of PFK enzyme in metabolism and cell cycle progression

A metabolic enzyme studied for over seven decades has a hidden second function - it can unwind RNA and promote cell cycle progression, an additional function beyond its role in energy production, according to a new study led by the University of Surrey.

16 Mar 2026

Boron-assisted reactions overcome solubility barriers in protein synthesis

Chemists from ETH Zurich have found a way to produce poorly soluble proteins by caging a uniquely reactive boron compound.

10 Mar 2026

Redefining the "aging brain" through diverse data

Age is more than just one number. While neuroscientists used to think of cognitive aging as a single trendline, they now realize that vast individual differences require a more predictive and personalized approach. As they uncover more factors that affect cognition over time, they are realizing that modeling the aging brain requires more diverse data than traditionally captured.

9 Mar 2026

Modified psilocybin compounds may treat brain disorders with fewer hallucinations

Psilocybin - the psychoactive compound in "magic mushrooms" - is gaining scientific attention for its potential in treating neuropsychiatric conditions including depression, anxiety, substance use disorders and certain neurodegenerative diseases.

6 Mar 2026

BCAT2 enzyme identified as a target for diabetic foot recovery

Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification is one of the key pathological mechanisms. Calcification in atherosclerotic plaque can cause stiffness and decreased compliance of the vascular wall, and induce atherosclerotic plaque rupture, which increases the risk of acute cardiovascular events.

6 Mar 2026