Treponema denticola News and Research

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Treponema denticola is a motile and highly proteolytic bacterium. The Gram-negative oral spirochete is associated with the incidence and severity of human periodontal disease. Treponema denticola levels in the mouth are elevated in patients with periodontal diseases and the species is considered one of the main etiological agents of periodontitis.

Antiseptic mouthwash reduces periodontitis bacteria in diabetes patients

More than bad breath, there is growing evidence that ongoing inflammation in the mouth, like with gum disease, is associated with serious diseases such as Alzheimer's disease or type 2 diabetes.

14 Feb 2024

Mice study unravels the role of T. denticola in Alzheimer's disease pathogenesis

Tau hyperphosphorylation is the key characteristic pathological hallmarks of Alzheimer's disease (AD). Recently studies showed periodontitis and periodontal pathogen are significant risk factors for AD.

26 Jun 2022

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

It seems that chewing gum is not a new trend! Researchers have found chewing gum that is 5,700 years old and it has provided clues regarding ancient DNA. A study with the findings was published in the journal Nature Communications. It is titled, “A 5,700-year-old human genome and oral microbiome from chewed birch pitch.”

18 Dec 2019

Bacteria linked to periodontitis may play role in onset of cancer

The bacteria that cause periodontitis, a disease affecting the tissues surrounding the teeth, seems to play a part also in the onset of pancreatic cancer, say the researchers at the University of Helsinki and the Helsinki University Hospital, Finland, and the Karolinska Institutet, Sweden.

16 Jan 2018

Study shows aging affects adaptive immune responses

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Jeffrey Ebersole, University of Kentucky, Lexington, USA, will present a study titled "Systemic Antibody Responses to Oral Bacteria with Aging." The AADR Annual Meeting is being held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.

21 Mar 2016

Scientists examine part of sample consisting of non-human DNA

Much of what we know about Oetzi - for example what he looked like or that he suffered from lactose intolerance - stems from a tiny bone sample which allowed the decoding of his genetic make-up.

16 Jul 2014

Bacteria that cause gum disease also promote heart disease, shows study

A University of Florida study shows that the same bacteria that cause gum disease also promotes heart disease - a discovery that could change the way heart disease is diagnosed and treated. Researchers report their findings today at the annual meeting of the American Society for Microbiology.

19 May 2014

Drug used to treat intestinal worms could protect people from periodontitis, says study

A drug currently used to treat intestinal worms could protect people from periodontitis, an advanced gum disease, which untreated can erode the structures-including bone-that hold the teeth in the jaw. The research was published ahead of print in Antimicrobial Agents and Chemotherapy.

11 Nov 2013

Old drug Auranofin may lead to new antibiotics

A mineral found at health food stores could be the key to developing a new line of antibiotics for bacteria that commonly cause diarrhea, tooth decay and, in some severe cases, death.

1 Jun 2009

Link between heart disease and periodontal bacteria

Researchers report this week that older adults who have higher proportions of four periodontal-disease-causing bacteria inhabiting their mouths also tend to have thicker carotid arteries, a strong predictor of stroke and heart attack.

7 Feb 2005

Comparative genomics to cast new light on other spirochete microbes

Three centuries after a pioneering Dutch microbiologist first observed the spiral-shaped oral pathogen Treponema denticola, scientists have deciphered the bacterium’s entire DNA sequence and used comparative genomics to cast new light on other spirochete microbes.

29 Mar 2004