Tumorigenesis News and Research

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Tumorigenesis is the process involved in the production of a new tumor or tumors.

Identification of Gli protein degradation signals that directly affect tumor latency

Identification of Gli protein degradation signals that directly affect tumor latency

Dr. Anthony E. Oro and colleagues (Stanford University) have identified two key Gli protein degradation signals that directly affect tumor latency in a mouse model of human skin cancer.

22 Jan 2006

Novel mouse model of medulloblastoma

Novel mouse model of medulloblastoma

A collaboration of researchers, led by Dr. Martine Roussel of St. Jude Children's Research Hospital, has developed a novel mouse model of medulloblastoma -- the most prevalent malignant pediatric brain tumor -- that the researchers hope will more accurately represent the genetic changes involved in human brain tumor development.

30 Oct 2005

Link between tissue tension and tumor formation

Link between tissue tension and tumor formation

Most investigations into cancer have focused on chemical signals, but a new research study provides rare insight into how mechanical force can regulate cellular behavior.

20 Sep 2005

Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

Two papers in the August 1 issue of Genes & Development explore the genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2.

19 Jul 2005

Curcumin has potent anticancer powers

Curcumin has potent anticancer powers

Curcumin, a spice commonly used in curries and other south Asian cooking, blocks a key biological pathway needed for development of melanoma and other cancers, say researchers from the University of Texas M. D. Anderson Cancer Center.

12 Jul 2005

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung.

16 Jun 2005

Importance of Fbw7 as an emerging tumor suppressor

Importance of Fbw7 as an emerging tumor suppressor

The DNA tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cancer-preventing proteins, p53 and pRb.

27 Feb 2005

Research reveals a novel key player in the initiation of colon cancer

Research reveals a novel key player in the initiation of colon cancer

Gastric and colorectal cancers account for more than 1 million deaths worldwide every year and several research groups have been working to identify the molecular events that result in the initiation and progression of these tumors.

3 Feb 2005

Class of cells that arises in mammary glands during maternity has stem cell-like properties

Class of cells that arises in mammary glands during maternity has stem cell-like properties

These parity-induced mammary epithelial cells (PI-MEC) have the ability to self-renew over many generations and to differentiate into numerous cellular subtypes.

7 Dec 2004

The p53 transcription factor plays a vital role in preventing cancer onset

The p53 transcription factor plays a vital role in preventing cancer onset

Researchers at the Uppsala Branch of the Ludwig Institute for Cancer Research have discovered that the transcription factor Yin Yang 1 (YY1) is a novel regulator of the tumor suppressor p53, which is inactivated in at least half of all human cancers.

2 Aug 2004

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