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Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

A team of scientists from Canada has recently characterized a panel of nanobodies against the spike protein of SARS-CoV-2.

22 Dec 2021

Computational analysis of the effect of SARS-CoV-2 Omicron variant spike protein mutations

A new study highlights the potential evolutionary trade-off observed in the omicron variant, detailing the dynamics of the protein structure, its interactions, and subsequent effects.

20 Dec 2021

Identifying protein targets in SARS-CoV-2 via machine learning

A new study provides insight on using an ML-based algorithm to analyze and predict therapeutic targets in emerging pathogens with a range of mutations.

17 Dec 2021

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment

Researchers investigated the mutations reported in the Omicron variant and its likely impact on the use of therapeutic antibodies in COVID-19 treatment as well as on vaccinated individuals.

17 Dec 2021

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

A new study measured antibody levels from blood samples of vaccinated individuals and individuals who recovered from COVID-19 illness.

17 Dec 2021

Receptor binding of SARS-CoV-2 Omicron variant compared to other variants

Researchers compared the binding of the new SARS-CoV-2 VOC Omicron’s RBD and ACE2 receptor with the original Wuhan SARS-CoV-2 strain and other VOCs such as Beta and Delta.

15 Dec 2021

Structure of human receptor and Omicron variant

Researchers studied the complex structure of the receptor-binding domain of the omicron variant with the human host receptor angiotensin-converting enzyme 2.

15 Dec 2021

Researchers develop a universal SARS-CoV-2 neutralizing antibody

A new study has been published in Frontiers in Immunology, where scientists developed a universal SARS-CoV-2 neutralizing antibody, MG1141A.

13 Dec 2021

Cellular properties of SARS-CoV-2 spike protein RBD in virus-infected African green monkey kidney epithelial cells

Researchers from the Biological Defence Programme of Singapore have investigated six of these antibodies.

13 Dec 2021

Autonomous genome annotation of SARS-CoV-2 genes, proteins and domains

In a new research paper, a group of scientists from various institutions offers a semi-supervised custom pipeline for annotating all SARS-CoV-2 genes, proteins, and functional domains.

12 Dec 2021

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

In a recent study, ten human PDZ-containing proteins showed significant interactions with the SARS-CoV-2 E protein in a PBM-dependent manner.

12 Dec 2021

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

The N-terminal domain has a fold that can bind sugar, and new research led by Jonathan Lees from Oxford Brookes University found the sugar-binding pockets near the N-terminal domain help to increase viral infectivity. Furthermore, the findings show that the SARS-CoV-2 sugar-binding pockets are evolving with added loops observed in the pockets of new variants.

9 Dec 2021

binding affinity News and Research

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

Computational analysis of the effect of SARS-CoV-2 Omicron variant spike protein mutations

Identifying protein targets in SARS-CoV-2 via machine learning

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

Receptor binding of SARS-CoV-2 Omicron variant compared to other variants

Structure of human receptor and Omicron variant

Researchers develop a universal SARS-CoV-2 neutralizing antibody

Cellular properties of SARS-CoV-2 spike protein RBD in virus-infected African green monkey kidney epithelial cells

Autonomous genome annotation of SARS-CoV-2 genes, proteins and domains

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

Computational comparison of SARS-CoV-2 Delta and Omicron variant binding affinity with ACE2

SARS-CoV-2 Delta variant changes receptor binding domain conformation to escape host antibodies

Possible impact of spike protein mutations on SARS-CoV-2 Omicron variant

Novel peptide-antibody fusion molecule enhances SARS-CoV-2 variant neutralization

Natural triterpenoids in licorice found to inhibit SARS-CoV-2

Impact of engineered ACE2-Fc on SARS-CoV-2 infection

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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