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Caris Life Sciences reveals identification of new mechanism of action to treat NHL

Caris Life Sciences, a leading innovator in molecular science focused on fulfilling the promise of precision medicine, today announced a data presentation, at the 59th American Society of Hematology Annual Meeting & Exposition in Atlanta, demonstrating the identification of a new mechanism of action to treat non-Hodgkin lymphoma (NHL).

13 Dec 2017

Radiation responsive molecules derived from horse chestnuts aid cancer imaging

Research at The City College of New York shows that cancer imaging can be simplified by a photonic process utilizing molecules derived from horse chestnuts.

12 Dec 2017

Study: Combination targeted therapy has high response rates in AML patients

Initial findings from a multi-national open-label phase Ib study of inhibitory drug therapy for relapsed or refractory acute myeloid leukemia (AML) have demonstrated a complete response in up to 50 percent patients say researchers at The University of Texas MD Anderson Cancer Center.

11 Dec 2017

Researchers generate 3D cell cultures to investigate mechanisms of drug resistance in breast cancer

An international research team headed by the University of Bern and the Netherlands Cancer Institute has developed 3D cell cultures in which genes can be specifically modified. They allow the study of genes that may cause therapy resistance in breast cancer.

11 Dec 2017

MILabs’ versatile Hybrid OI/CT system installed at Guangdong University of Technology

The Institute of Biomedical and Pharmaceutical Sciences at Guangdong University of Technology in Guangzhou – China, has successfully installed a VECTor5 Hybrid OI/CT system from MILabs.

5 Dec 2017

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.

From Sartorius 5 Dec 2017

Clearance of cancer cell debris via pro-resolving mediators can prevent tumor recurrence

Cancer therapies are designed to kill tumor cells, but produce tumor cell debris in the process. In a study published in The Journal of Experimental Medicine, researchers from Brigham and Women's Hospital and colleagues show that leftover debris can stimulate inflammation and tumor growth, but that molecules called resolvins can block that unwanted inflammatory response.

5 Dec 2017

Malvern Panalytical Announce Efforts Towards a Platform For Protein Aggregation Profiling

Malvern Panalytical announces the launch of a collaborative project which aims to support the development of existing and next generation biopharmaceutical products.

From Malvern Panalytical 4 Dec 2017

Researchers refine method to improve early detection of ovarian cancer

Researchers at Rice University and the University of Texas MD Anderson Cancer Center have refined and, for the first time, run in vivo tests of a method that may allow nanotube-based probes to locate specific tumors in the body.

1 Dec 2017

Postnova’s AF2000 FFF system used to unlock mystery of neurodegenerative diseases

Postnova Analytics reports that the Department of Molecular Biology & Biotechnology at the University of Sheffield is using their AF2000 Field Flow Fractionation system to investigate the mechanism of amyloid formation, a protein mis-folding process implicated to be the cause of Alzheimer’s and other neurodegenerative diseases.

From Postnova Analytics 1 Dec 2017

Study focuses on improving pharmacokinetic properties of therapeutic aptamers

Designing new therapeutic DNA aptamers with diverse side chains can improve their ability to interact with targets, and a new study describes characteristics of these side chains that may determine how long the aptamers remain in the bloodstream.

30 Nov 2017

Invasive cells deploy a trick to squeeze through barriers

Invasive cells deploy a trick to break through tissues and spread to other parts of the body, researchers report.

28 Nov 2017

Study: Women may be more susceptible to concussions due to more breakable nerve fibers

Women have smaller, more breakable nerve fibers in the brain compared to men that may make them more susceptible to concussions, suggests a new study from Penn Medicine neuroscientists published online today in the journal Experimental Neurology.

27 Nov 2017

Scientists produce images of brain tissue affected by Alzheimer's disease using ‘Raman’ technology

Using 'Raman' optical technology, scientists of the University of Twente in The Netherlands, can now produce images of brain tissue that is affected by Alzheimer's disease. The images include the surrounding areas, already showing changes.

23 Nov 2017

Researchers uncover how rogue immune cells gain access to neurons in multiple sclerosis

Drug designers working on therapeutics against multiple sclerosis should focus on blocking two distinct ways rogue immune cells attack healthy neurons, according to a new study in the journal Cell Reports.

21 Nov 2017

Probing living cells with AFM

An interview with Prof. David Alsteens, Université Catholique de Louvain conducted by April Cashin-Garbutt, MA (Cantab).

From Bruker Nano Surfaces and Metrology 21 Nov 2017

Over-the-counter decongestant found to be effective inhibitor of tumor stroma

CANCER researchers seeking non-toxic alternatives to harmful chemotherapy are reporting a highly significant result for a humble cold remedy.

20 Nov 2017

New discovery may lead to natural products for preventing dental caries

A new discovery may one day lead to natural anticavity products, researchers report. The scientists from West China School of Stomatology and Academic Centre for Dentistry Amsterdam have figured out the main active ingredient of Galla Chinensis, a natural herb, and further improved its anti-caries efficacy. The finding is published in The Open Dentistry Journal.

16 Nov 2017

Nanowires could be potential drug delivery tools for neurodegenerative diseases

Millions of Americans suffer from neurodegenerative diseases such as Alzheimer's and Parkinson's. Researchers have identified promising new treatments, such as cerebrolysin, but current clinical approaches are ineffective because critical concentrations of the drug dissipate within the body before reaching the blood-brain barrier and central nervous system.

15 Nov 2017

SUNY Downstate professor receives two awards to support research on vision-threatening diseases

Brahim Chaqour, PhD, professor of cell biology and ophthalmology at SUNY Downstate Medical Center, has received two awards to support research into treatment of currently incurable vision-threatening diseases. The new awards, totaling $2,008,973, are from the National Eye Institute of the National Institutes of Health.

14 Nov 2017