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pH comes from the term “power of Hydrogen”, or the hydrogen ion concentration present in a given solution. It helps to measure the acidity or alkalinity of a substance.

Terminally exhausted T cells may remain competent for transcription, researchers say

During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this state was irreversible. However, new insights from University of Pittsburgh and UPMC researchers suggest that even the most fatigued T cells can be revived.

8 Aug 2022

NIH researchers develop three-dimensional structure of twinkle protein

Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases.

5 Aug 2022

Research suggests a new nanomedicine strategy for treatment of IBD patients

Inflammatory bowel disease (IBD), also known as "green cancer", is a chronic, non-specific disease of the intestine. IBD includes ulcerative colitis and Crohn's disease, both of which tend to be debilitating, lifelong conditions that can prove fatal in severe cases. Currently, there is no cure for IBD. The main clinical treatments are drugs such as aminosalicylic acid preparations and corticosteroids, but they are often accompanied by gastrointestinal problems, anemia, and various intestinal complications. Finding alternative, more effective options is a priority for researchers.

5 Aug 2022

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Primary liver cancer, the third-leading cause of cancer-related death worldwide, takes more than 30,000 lives in the United States each year. The high mortality rates can be attributed in part to the fact that a significant portion of the patients are detected at a late stage, when potentially curative treatments are no longer an option. Unfortunately, today's screening methods are not able to routinely provide accurate, early detection.

5 Aug 2022

KAIST researchers engineer a bacterial strain capable of producing lutein

A research group at KAIST has engineered a bacterial strain capable of producing lutein. The research team applied systems metabolic engineering strategies, including substrate channeling and electron channeling, to enhance the production of lutein in an engineered Escherichia coli strain.

4 Aug 2022

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

Metastatic bladder cancer is generally incurable, so new therapies are an urgent need. Researchers at the University of Alabama at Birmingham now report a potential treatment for a quarter of bladder cancers.

4 Aug 2022

Higher suPAR levels linked with increased risk of blood clot formation

Blood clots are thought to occur in as many as a third of patients hospitalized with COVID-19. In many cases these clots can be deadly, such as pulmonary embolisms-;blood clots that travel to the lungs. In fact, in nearly one third of patients with COVID-19, these clots led to death.

4 Aug 2022

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

We are increasingly being exposed to endocrine-disrupting chemicals (EDCs) that interfere with the normal functioning of our hormones. Bisphenol A (BPA) and phthalates, which are widely used in consumer products including plastics, aluminum cans, pharmaceuticals, and cosmetics, are well-known EDCs.

4 Aug 2022

Designing an app to diagnose ALS

In this interview, we speak to Dr. Jordan Green about his latest research partnership with Modality.AI that investigated whether an app could be used to effectively diagnose speech decline due to ALS.

4 Aug 2022

A California man’s ‘painful and terrifying’ road to a monkeypox diagnosis

Two days after Kevin Kwong flew home to California from New York, his hands itched so badly, the pain jolted him from sleep. He thought the problem was eczema.

4 Aug 2022

BBRF hosts a free webinar on manipulating memories to help treat brain illness

The Brain & Behavior Research Foundation is hosting a free webinar, "Manipulating Memories to Help Treat Brain Illness" on Tuesday, August 9, 2022, at 2:00 pm EDT.

3 Aug 2022

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Two years ago, University of Alabama at Birmingham researchers and colleagues reported that reductive stress -; an imbalance in the normal oxidation/reduction, or redox, homeostasis -; caused pathological changes associated with heart failure in a mouse model.

3 Aug 2022

Glioma incidence and outcomes differ based on geographic/ancestral origins of Hispanic communities

Although typically classified as a single ethnic group, people of Hispanic heritage have markedly different risks for brain tumors based on their geographic origins, suggesting greater diversity that warrants attention in the health care setting.

3 Aug 2022

Inexpensive, self-driven microfluidic chip rapidly detects Hepatitis C virus in about 45 minutes

Hepatitis C affects more than 354 million people worldwide. About 75 to 85 percent of people who have it get a long-term infection referred to as chronic Hepatitis C. Left untreated, it could lead to cirrhosis, liver cancer or liver failure.

3 Aug 2022

Women with a history of hypertensive disorders of pregnancy more likely to develop dementia

Hypertensive disorders of pregnancy (HDP) — conditions of high blood pressure including chronic/gestational hypertension and preeclampsia — have been strongly linked to heart disease in later life, but, before today, little research has connected these disorders with cognition.

3 Aug 2022

Women with a history of preeclampsia have increased markers of brain cell damage, inflammation

Preeclampsia is a serious complication of pregnancy characterized by high blood pressure and kidney damage.

3 Aug 2022

Study pinpoints a three-pronged approach that makes liver cancer cells stop growing

Liver cancer's rapid growth leads to a vulnerability in its energy-production and cell-building processes that may be potently exploited with a new combination-treatment strategy, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

3 Aug 2022

New and efficient method Monkeypox virus sequencing

In a recent study posted to the medRxiv* preprint server, Spanish researchers described a new enrichment method for metagenomic sequencing of the monkeypox virus (MPXV).

2 Aug 2022

Novel algorithm provides rich, detailed information on protein location and function within a cell

Humans are good at looking at images and finding patterns or making comparisons. Look at a collection of dog photos, for example, and you can sort them by color, by ear size, by face shape, and so on. But could you compare them quantitatively? And perhaps more intriguingly, could a machine extract meaningful information from images that humans can't?

2 Aug 2022

Jianhua Zhao secures $2.4 million NIGMS grant to study the molecular machinery of proteolysis

Assistant Professor Jianhua Zhao, Ph.D., has been awarded a unique and competitive grant from the National Institute of General Medical Sciences, part of the National Institutes of Health.

2 Aug 2022

pH News and Research

Further Reading

Terminally exhausted T cells may remain competent for transcription, researchers say

NIH researchers develop three-dimensional structure of twinkle protein

Research suggests a new nanomedicine strategy for treatment of IBD patients

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

KAIST researchers engineer a bacterial strain capable of producing lutein

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

Higher suPAR levels linked with increased risk of blood clot formation

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

Designing an app to diagnose ALS

A California man’s ‘painful and terrifying’ road to a monkeypox diagnosis

BBRF hosts a free webinar on manipulating memories to help treat brain illness

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Glioma incidence and outcomes differ based on geographic/ancestral origins of Hispanic communities

Inexpensive, self-driven microfluidic chip rapidly detects Hepatitis C virus in about 45 minutes

Women with a history of hypertensive disorders of pregnancy more likely to develop dementia

Women with a history of preeclampsia have increased markers of brain cell damage, inflammation

Study pinpoints a three-pronged approach that makes liver cancer cells stop growing

New and efficient method Monkeypox virus sequencing

Novel algorithm provides rich, detailed information on protein location and function within a cell

Jianhua Zhao secures $2.4 million NIGMS grant to study the molecular machinery of proteolysis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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