PhysioMimix Multi-chip Liver plates enable the in vitro creation of 3D human liver tissues from primary human liver cells.
PhysioMimix Liver-12 and -48 plates are designed to replicate the 3D architecture of the liver capillary bed under continuous cell culture media perfusion.
For at least four weeks, perfusion sustains cell phenotypes and functions in liver-on-a-chip cultures by continuously supplying oxygen and nutrients. The plates work with:
- Primary cells
- Induced-pluripotent stem cells
- Immortalized cell lines
- Circulating immune cells
- Precision-cut tissue slices
- Organoids
Which Liver plate matches your needs?
Liver-12 plate
Image Credit: CN-Bio
Intended to produce the ideal environment for primary human hepatocytes and non-parenchymal cells to get a profound mechanistic understanding of the mechanism of a drug or disease.
Liver-48 plate
Image Credit: CN-Bio
Aimed at lowering sample costs, improving throughput, and boosting data reliability for higher throughput studies comparing drug responses.
PhysioMimix OOC range compatibility
Source: CN-Bio
| |
Single-organ Systems |
Multi-organ System |
| |
Standard |
HT |
Standard |
| Liver-12 plate |
✓ |
✓ |
✓ |
| Liver-48 plate |
X |
✓ |
X |
PhysioMimix Liver plate applications
- Non-alcoholic steatohepatitis
- Hepatitis B virus
- Drug-induced liver injury
- Immune-mediated toxicity
- Drug metabolism
Related consumables
- Dual-organ plate
- 3D validated cells
- NASH-in-a-box kit