Easily automate titrations, measure water content with Karl Fischer techniques, and run multiparameter assays using METTLER TOLEDO's modular autosamplers.
Start with the nine-position Rondolino, scale up to the single-row InMotionFlex™ that accommodates 11-50 samples, enhance throughput with the extending-arm InMotion Pro, capable of handling up to 182 samples, or operate overnight with the dual-tower InMotion Max, which can manage 303 positions.
The dedicated InMotion KF Ovens facilitate sealed-vial testing. OneClick™, SmartSample™, and LabX™ ensure that results are fully traceable.
Rondolino: The compact 9-sample carousel automates the daily quality control process.
InMotion Flex: Flex Base streamlines workflows involving one-row, 11-50 sample routine, mixed vials and beakers.
InMotion Pro: The extended-arm tower, equipped with water-bath racks, is capable of processing up to 182 samples.
InMotion Max: The dual-tower, water-bath system efficiently analyzes more than 300 samples completely overnight.
Unified platform: OneClick™ control, SmartSample™ IDs, and LabX e-signatures guarantee traceable and compliant throughput across all scales.
Highlight
Automated Karl Fischer water content determination
Observe the InMotion KF Flex oven as it pierces sealed vials, heats them to the ideal Temperature Scan set-point, and directs moisture into the titration cell under a digitally regulated gas flow. OneClick initiates the process, StatusLight™ indicates progress, and secure one-piece caps ensure that analysts remain safe from solvents.
InMotion Karl Fischer Titration Oven Autosampler - METTLER TOLEDO
High-throughput automation
Rondolino: The compact carousel automates nine quality control titrations as the user prepares the next batch.
InMotion Flex / Pro / Max: Flex accommodates a maximum of 50 samples; Pro's multi-row racks can handle over 180; Max processes more than 300, with each unit automatically dosing, rinsing, and performing unattended PowerShower™ cleaning.
InMotion KF: The dedicated Karl Fischer oven autosampler provides water-content determinations using the drying oven extraction method.
Parallel: Connect two autosamplers to one T9 for doubled throughput.
Image Credit: Mettler Toledo – Titration Systems
Modular scalability
Snap-in modules: Incorporate pumps, burette drives, sensor boards, aliquot kits, and KF ovens.
Water-bath racks: Ensure accurate temperature regulation for each sample within the rack
Boost capacity: Exchange racks, incorporate an additional tower, or connect another autosampler
Parallel mode: Dual trays or twin towers conduct simultaneous titrations, effectively doubling the throughput.
User safety: CoverUp™ lids protect operators from unstable vapors and smelly solvents
Image Credit: Mettler Toledo – Titration Systems
Effortless compliance and data integrity
LabX audit trail: Each rack movement, solvent alteration, and outcome is recorded with time stamps in accordance with 21 CFR Part 11 / EU Annex 11 electronic signatures and user-role management.
Sample-centric security: SmartSample™ RFID or barcode associates the ID and weight of each vial with its corresponding rack position, thereby preventing any mix-ups.
Tamper-proof archiving: The run files and sensor-status snapshots are preserved in a redundant LabX database, ensuring they are inspection-ready for years.
Image Credit: Mettler Toledo – Titration Systems
Intelligent workflow control
OneClick launch: Customized home screens initiate a complete rack run, autosampler, and titrator with just one tap.
Conditional logic: Pre-programmed Conditions activate particular actions, such as repeating, rinsing, or discarding, according to established criteria, thereby minimizing the need for manual oversight.
StatusLight™ signals: The tower LEDs illuminate in green, yellow, or red, providing an immediate indication of when to load, intervene, or allow the system to operate uninterrupted.
Image Credit: Mettler Toledo – Titration Systems
Autosamplers and sample changers for every application
Image Credit: Mettler Toledo – Titration Systems
InMotion, InMotion-KF Ovens, and Rondolino
Automate titrations and Karl Fischer workflows at any scale. The compact Rondolino carousel accommodates nine samples, while the InMotion Flex, Pro, and Max can process between 11 and 303 beakers. Additionally, InMotion KF Ovens enhance the efficiency of sealed-vial moisture testing.
OneClick, SmartSample, PowerShower, water-bath racks, and LabX audit trails provide traceable, hands-free throughput, allowing analysts to focus on generating high-value, data-driven insights.
Sample changer
Rondolino sample changer
Nine-sample carousel automates standard titrations within a notebook-sized footprint, enabling busy laboratories to complete quality control while allowing operators to concentrate on more valuable tasks.
Image Credit: Mettler Toledo – Titration Systems
General-purpose InMotion autosamplers
InMotion Flex autosampler
The autosampler can handle between 11 and 50 samples in a single run; rapid rack changes enable laboratories to transition from manual titration to automated efficiency while preserving current methodologies.
Image Credit: Mettler Toledo – Titration Systems
InMotion Pro autosampler
The autosampler, featuring an extending arm and a multi-row design, is capable of preparing between 23 and 182 samples in a single sequence. This innovation allows analysts to work more efficiently and reduces turnaround times for mid to high-volume workflows.
Image Credit: Mettler Toledo – Titration Systems
InMotion Max autosampler
Twin towers are designed to queue 24-303 samples, facilitating genuine overnight, hands-free operation. This feature is particularly advantageous when high throughput and reduced operator involvement are essential.
Image Credit: Mettler Toledo – Titration Systems
InMotion Karl Fischer Oven autosamplers
InMotion KF Six Oven autosampler
The six-position oven carousel of the autosampler confirms water content in either duplicate or triplicate samples. It is the only KF oven compatible with EVA V1 and C1 titrators, making it suitable for low-volume, unattended operations.
Image Credit: Mettler Toledo – Titration Systems
InMotion KF Flex Oven autosampler
The compact oven accommodates 26 sealed vials within a 25 cm footprint, providing dependable water content testing in routine quality control environments.
Image Credit: Mettler Toledo – Titration Systems
InMotion KF Pro Oven autosampler (20 mL)
The Pro oven accommodates twenty 20 mL vials, enhancing high-capacity moisture workflows in laboratories focused on pharmaceuticals, polymers, and specialty chemicals.
Image Credit: Mettler Toledo – Titration Systems
InMotion KF Pro Oven autosampler (10 mL)
The Pro variant includes twenty-four 10 mL vials, effectively balancing throughput and reagent consumption for standard water-content analysis.
Image Credit: Mettler Toledo – Titration Systems
InMotion KF Pro Oven autosampler (5 mL)
The small-volume Pro rack accommodates twenty-six 5 mL vials, thereby reducing the amount of reagents used while ensuring accurate moisture measurements for valuable materials.
Image Credit: Mettler Toledo – Titration Systems
Autosampler model comparison
Source: Mettler Toledo – Titration Systems
| Key Feature |
Rondolino Sample
Changer |
InMotion Flex
Autosampler |
InMotion Pro
Autosampler |
InMotion Max
Autosampler |
InMotion KF
Flex Oven |
InMotion KF
Pro Oven |
InMotion KF
Six Oven |
| Max sample positions* |
9 |
50 (25 mL) /
11 (250 mL) |
182 (25 mL) /
23 (180 mL) |
303 (25 mL) /
24 (250 mL) |
26
(10 mL vials) |
20 / 24 / 26
(rack dependent) |
6 |
| Rack Ø / footprint |
25 ×35 cm |
Ø 42 cm tray, 25 cm wide base |
Ø 42 cm tray, 33 cm wide base |
Ø 57 cm tray, 33 cm wide base |
25 cm wide
base |
25 cm wide
base |
25 cm wide
base |
| Second tower option |
– |
– |
Yes (except
25 mL rack) |
Built-in twin towers |
– |
Dual-autosampler link |
– |
| PowerShower™ cleaning |
Optional |
✓ |
✓ |
✓ |
– (oven) |
– (oven) |
– (oven) |
| SmartSample™ / barcode ID |
– |
✓ full rack |
✓ outer rows |
– |
– |
– |
– |
| Water-bath racks |
– |
Optional |
Optional |
Optional |
– |
– |
– |
| Suitable assays |
Routine titration QC |
Acid/base, redox, KF direct, multiparameter |
Medium–high-volume titrations, duplicate runs |
Overnight high-volume
titrations |
Sealed-vial KF, daily QC |
High-throughput sealed-vial KF |
Duplicate/triplicate
KF spot
checks |
| Throughput style |
Sequential |
11-50 samples, sequential |
23-182 samples, sequential or duplicate |
24-303 samples, overnight or duplicate |
26 vials per rack, sequential |
Up to 120 vials per series, sequential |
5 vials
per series |
| Typical lab size |
Small QC bench |
Growing labs upgrading from manual |
Mid-to high-volume QC |
Central QC / production labs |
Everyday KF Water Content Determination |
Pharma, chemical, battery QC |
Pilot plants, field labs |
| LabX™ / OneClick™ integration |
Yes |
Yes |
Yes |
Yes |
Yes |
Yes |
Local control (USB / network export) |
| Compliance & data |
Traceable runs via LabX |
21 CFR 11 / Annex 11 with LabX |
Same |
Same |
Same |
Same |
Exports data to LIMS/USB |
Elevate the autosampler with smart accessories
Scale InMotion autosamplers equipped with 11-303-place racks, CoverUp™ lids, water-bath trays, Aliquot dosing, PowerShower™ cleaning, SmartSample™ ID, along with a solvent manager or digital gas-flow control for KF ovens. Rondolino includes the optional PowerShower™. OneClick automatically detects each add-on, enhancing throughput and data integrity while maintaining the same bench space.
Image Credit: Mettler Toledo – Titration Systems
Application spotlight
Determining base number in motor oils via ASTM D4739
Quantification of additive content and monitoring of oil degradation are achieved through automated base number titration with HCl. This ASTM D4739-compliant method uses the T9 with InMotion Max to deliver efficient and repeatable results, making it suitable for petrochemical laboratories tracking motor oil performance over time.
Image Credit: Mettler Toledo – Titration Systems
Determining kappa number in pulp samples with DispenSix
Lignin content analysis is automated using DispenSix and InMotion for redox back-titration with permanganate and thiosulfate. This ISO 302:2004-compliant approach ensures precise chemical dosing and reliable results, ideal for pulp and paper laboratories focused on optimizing bleaching processes and fiber characterization.
Image Credit: Mettler Toledo – Titration Systems
Water content of lithium-ion battery electrolyte
Accurate water determination in lithium-ion battery electrolytes is performed using HYDRANAL™ NEXTGEN FA reagents combined with coulometric Karl Fischer titration. This method prevents side reactions and provides precise measurements even in the presence of additives, making it suitable for battery laboratories requiring ppm-level water control.
Image Credit: Mettler Toledo – Titration Systems
Parallel titration of duplicates: Analysis with ion-selective electrodes
The analysis of calcium, fluorine, chloride, and copper is expedited by conducting duplicate titrations simultaneously with ion-selective electrodes. The InMotion + T9 setup increases sample throughput, ensures consistent results, and optimizes analyst productivity, ideal for quality control laboratories processing large sample volumes.
Image Credit: Mettler Toledo – Titration Systems
Measuring water in protein powders with KF Oven
Water content in whey, casein, soy, and other products is measured using volumetric Karl Fischer titration with the InMotion KF Oven. This method guarantees accurate, decomposition-free moisture results, making it suitable for quality assurance laboratories monitoring the nutritional quality and shelf life of protein powders.
Image Credit: Mettler Toledo – Titration Systems