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Shortening chromosomes cause for earlier cancer onset in families with Li-Fraumeni syndrome

In families with a high incidence of Li-Fraumeni syndrome, the ends of individuals' chromosomes act somewhat like a lit fuse, according to researchers at The Hospital for Sick Children in Toronto. Their findings detail how telomeres, the ends of the chromosomes, shorten with every successive generation, leading to more severe cancers at an earlier age.

15 Feb 2007

Mechanism driving iron overload in thalassemia identified

Led by researchers at Weill Cornell Medical College in New York City, an international group of scientists has pinpointed a specific genetic relationship as the cause of dangerous iron overload in persons with a form of the inherited blood disease, beta-thalassemia.

14 Feb 2007

Dipeptidyl peptidase I critical for early growth of abdominal aortic aneurysms

Surgery is the only treatment for an abdominal aortic aneurysm, a weak spot in the body's main artery that dilates dangerously over time.

13 Feb 2007

People from lower socioeconomic backgrounds worse off following heart attack

People from lower socioeconomic backgrounds who suffer a heart attack come to the emergency department more often, are less likely to be treated aggressively and have higher mortality rates a year after the attack, says new University of Alberta research that has important implications for access to cardiac care.

13 Feb 2007

Wearing sunscreen at all times could starve the body of vitamins

Professor Mary Norval and a team from the University of Edinburgh Medical School have studied recent research into effects of the UV light on human health - and the positive and negative implications of ozone depletion.

13 Feb 2007

Cravings for chocolate increased by dieting

Those planning to break New Year's dieting resolutions with a feast of chocolate on Valentine's Day, should think again, according to researchers at the University of Hertfordshire.

13 Feb 2007

Causes of heart failure

In most cases, heart failure is due to the impaired ability of the heart muscle to pump blood through the body. However, in some cases, the heart no longer functions normally because it is not filled properly. This process is largely determined by the elastic scaffold protein titin.

12 Feb 2007

Researchers discover how to fight iron disorders with a drug against hypertension

We all know that iron deficiencies are dangerous, but also too much iron is bad for our health. Our body stores excess iron in various tissues, where it can lead to organ failure and even death if not treated before irreversible damage has occurred.

12 Feb 2007

Octopuses and depression

Researchers often use animals to help them resolve problems that can be applied to people. Dr. Jean Boal, a biology professor at Millersville University of Pennsylvania, is developing a new and unique way to research the causes and effects of depression with the help of octopuses.

12 Feb 2007

Targeting bladder tumor cells in vivo and in the urine with a peptide identified by phage display

Efforts to create nanoparticles that deliver anticancer drugs or imaging agents to tumors while avoiding healthy cells are often stymied by a lack of known tumor targets, that is, molecules found on the surface of malignant cells but not healthy cells.

12 Feb 2007

Natural gum improves gold nanoparticles for cancer imaging

Gold nanoparticles have shown significant promise as agents to detect and treat cancer, but researchers have had difficulty creating gold nanoparticles that have suitable pharmacological properties for use in humans.

12 Feb 2007

DNA-encoded antibody libraries

During the past several years, breakthroughs in genomic and proteomic technologies have enabled researchers to more clearly identify the biochemical networks that malfunction when a healthy cell becomes malignant.

12 Feb 2007

GenoMed discovers African gene

GenoMed has announced that it has found the "African gene," responsible for the much higher incidence of diabetes, high blood pressure, and kidney failure among people of African ancestry than whites.

12 Feb 2007

Siestas good for your heart!

Siestas could be the latest way of avoiding stress and protecting the heart from disease.

12 Feb 2007

Changes in breast cancer management

Aggressive research currently underway brings hope of dramatic advances in breast cancer management, according to a new review.

12 Feb 2007

Type-2 diabetes genes identified

The most important genes associated with a risk of developing type-2 diabetes have been identified, scientists report today in a new study.

11 Feb 2007

PALB2 gene mutation elevates risk of breast cancer four-fold

Cancer is a complex and common disease caused by a combination of both genetic and environmental factors. An inherited predisposition seems to be involved in at least 5-10 per cent of all cases of breast cancer.

11 Feb 2007

Back regions of the brain, which control vision, grow significantly faster than prefrontal region in newborns

The regions of the brain that control vision and other sensory information grow dramatically in the first few months following birth, while the area that controls abstract thought experiences very little growth during the same period, University of North Carolina at Chapel Hill researchers have found.

11 Feb 2007

Researchers discover master switch for a tumor suppressive network

A decades-old cancer mystery has been solved by researchers at Cold Spring Harbor Laboratory (CSHL). "We not only found a critical tumor suppressor gene, but have revealed a master switch for a tumor suppressive network that means more targeted and effective cancer therapy in the future," said CSHL Associate Professor Alea Mills, Ph.D.

11 Feb 2007

New, rapid-detection system for Salmonella

The food and drink we consume have to pass strict quality controls. Nevertheless, these measures are not always sufficient, given that sometimes certain foodstuffs can still give rise to food poisoning, most often caused by micro-organisms. The Salmonella bacterium is undoubtedly one of the best known of these.

8 Feb 2007