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Lack of a blood clotting protein may protect against clogged arteries

Reporting in the July 18 issue of The Journal of Experimental Medicine, a group of scientists in Wurzburg, Germany show that the lack of a blood clotting protein may protect against clogged arteries with no risk of excessive bleeding.

11 Jul 2005

Newly discovered gene mutation may account for many cases of immune deficiency

...in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), report researchers in the July issue of Nature Genetics. The discovery may lead to a new diagnostic test for these conditions, which make people highly susceptible to infections and often go unrecognized because of a lack of good tests.

11 Jul 2005

Research explains one of the fundamental mysteries of multiple sclerosis

Scientists have pinpointed a chemical messenger that frees some white blood cells from the body's normal constraints, allowing the cells to act like renegades that could damage nerves in the central nervous system. The work, to be published in the July 15 issue of the Journal of Immunology and just published on-line, helps explain one of the fundamental mysteries of multiple sclerosis (MS).

11 Jul 2005

New approach to preventing or reversing heart failure

Duke University Medical Center researchers have identified a new protein that plays a critical role in enabling the heart to respond to such external stimuli as exercise or stress, as well as in the progressive loss of heart function that is heart failure, the researchers said.

11 Jul 2005

Fat in the bloodstream linked to heart attacks

New research, by Dr. Sotirios Tsimikas of the University of California, San Diego, has produced the first convincing evidence that a type of fat in the bloodstream can trigger the earliest conditions that lead to clogged blood vessels, the highest cause of heart attacks.

7 Jul 2005

Findings shed light on the underlying mechanisms that cause hypertension

An enzyme known to cause hypertension increases blood pressure by activating tiny pores, or channels, in kidney cells that allow increased levels of sodium to be reabsorbed into the blood, researchers at UT Southwestern Medical Center have found.

6 Jul 2005

Researchers clarifiy role of Notch protein in T-cell development

Researchers at the University of Pennsylvania School of Medicine have recently clarified the role of the Notch protein in T-cell development. T cells are required for many aspects of immunity, including fighting viral infections, providing cancer surveillance, and regulating multiple aspects of the immune response.

6 Jul 2005

Patients suffering from oral cancer have increased levels of certain bacteria in their saliva

Six common species of bacteria were found at significantly higher levels in the saliva of patients with oral squamous cell carcinoma (OSCC) than in the saliva of healthy individuals.

6 Jul 2005

Researchers discover sections of the chromosomes of lung cancer cells where cancer-related genes may lurk

With equipment designed to probe the smallest segments of the genetic code, researchers at Dana-Farber Cancer Institute and collaborating institutions have found something much larger: sections of the chromosomes of lung cancer cells where cancer-related genes may lurk.

6 Jul 2005

Researchers have discovered a key regulatory molecule for Huntington's disease

Researchers have discovered a key regulatory molecule whose overactivation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease.

6 Jul 2005

Novel inhibitor offsets neurotoxic effects of tPA - possible new stroke treatments

A research team lead by the Burnham Institute has synthesized and tested a new series of inhibitors that can prevent the type of nerve cell injury and death associated with many neurodegenerative diseases and stroke.

6 Jul 2005

Fat adults more likely to have increased insulin resistance, a risk marker for Type 2 diabetes

Adult lifestyle has more influence on your chances of developing diabetes than childhood experience, according to new research whose findings contradict previously-held beliefs.

6 Jul 2005

Research discovers new deadly link to sickle cell disease

A new study led by a researcher at Children's Hospital & Research Center at Oakland is the first to find that an amino acid deficiency in sickle cell disease is the result of hemolysis, a process where red blood cells rupture and release their contents into the blood stream. Low availability of the amino acid arginine is associated with lung disease and death in adult sickle cell patients.

6 Jul 2005

Evidence suggests that antibiotic use in agriculture has contributed to antibiotic resistance in the pathogenic bacteria of humans

Doctors have become increasingly concerned by the problem of "super-bugs" - bacteria that have become resistant to standard antibiotics.

6 Jul 2005

Urine testing may predict birthmarks

Vascular anomalies - birthmarks caused by abnormal development of arteries, capillaries, veins or lymph vessels - can sometimes begin to progress, requiring aggressive treatment to save the child's health or vision. Research at Children's Hospital Boston now suggests that urine testing can help monitor these anomalies and predict those about to become a serious threat.

6 Jul 2005

Drug abusers are increasingly turning to a slow-release form of drug fentanyl

Drug abusers are increasingly turning to a slow-release form of a powerful painkiller for a quick and dangerous high, University of Florida researchers warn. The trend is raising alarm as the number of people dying from an overdose of the drug fentanyl, an opioid 100 times more potent than morphine, rises.

6 Jul 2005

Gamblers and addicts have a lot in common

A group of researchers from the U.S., the UK, and New Zealand, have apparently found that problem gamblers often display many similar personality traits as people who abuse alcohol, marijuana, and nicotine.

6 Jul 2005

Discovery of genes that impact the development and function of blood stem cells

Researchers at the University of Minnesota have identified for the first time a group of genes that impact the development and function of blood stem cells, a discovery that brings researchers a step closer to harnessing the power of stem cells for disease treatments.

6 Jul 2005

Substantial public health impacts of 1990 invasion and occupation of Kuwait

Researchers from the Harvard School of Public Health (HSPH) made public the findings of Phase I of their investigation of the public health impacts on Kuwaiti Nationals of Iraq's 1990 invasion and seven-month occupation of Kuwait.

6 Jul 2005

Potential novel treatment targets for the most common form of childhood epilepsy

New research suggests novel treatment targets for the most common form of childhood epilepsy - with the potential to have fewer side effects than traditional therapy. The findings from Wake Forest University School of Medicine are reported in the July issue of the Journal of Neurophysiology.

6 Jul 2005